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- Aad, G, et al.
(author)
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- 2015
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swepub:Mat__t
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- Huo, Meiling, et al.
(author)
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A heteroepitaxially grown two-dimensional metal-organic framework and its derivative for the electrocatalytic oxygen reduction reaction
- 2022
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In: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7488 .- 2050-7496. ; 10:19, s. 10408-10416
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Journal article (peer-reviewed)abstract
- Two-dimensional (2D) metal–organic frameworks (MOFs) have become a hot topic recently due to their high surface area, larger number of exposed active sites, and improved conductivity. Combining different 2D MOFs could introduce new physical and chemical properties. Here, we have synthesized a heteroepitaxially grown 2D zeolitic imidazolate framework with a leaf-like morphology (ZIF-L). ZIF-L has a layer-by-layer dense structure, which possesses a high content of N and metal ions as active sites. ZIF-L-Co is heteroepitaxially grown on ZIF-L-Zn, while ZIF-L-Zn@ZIF-Co has been successfully prepared. After pyrolysis, the heteroepitaxially grown MOF derived ultra-small Co nanoparticle immobilized nitrogen doped carbon (NC) material (HM-Co@NC) exhibits superior oxygen reduction reaction (ORR) activity (Eonset = 0.998 V, E1/2 = 0.905 V) and better stability than Pt/C, achieving well-qualified assemblies for use in rechargeable Zn–air batteries.
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- Cheng, J., et al.
(author)
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Molecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI
- 2016
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 6
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Journal article (peer-reviewed)abstract
- The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating neurological diseases. κOR selective 6′-GNTI was proved to be a G-protein biased agonist, whereas 5′-GNTI acts as an antagonist. To investigate the molecular mechanism of how these two ligands induce different behaviors of the receptor, we built two systems containing the 5′-GNTI-κOR complex and the 6′-GNTI-κOR complex, respectively, and performed molecular dynamics simulations of the two systems. We observe that transmembrane (TM) helix 6 of the κOR rotates about 4.6° on average in the κOR-6′-GNTI complex. Detailed analyses of the simulation results indicate that E2976.58 and I2946.55 play crucial roles in the rotation of TM6. In the simulation of the κOR-5′-GNTI system, it is revealed that 5′-GNTI can stabilize TM6 in the inactive state form. In addition, the kink of TM7 is stabilized by a hydrogen bond between S3247.47 and the residue V691.42 on TM1.
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- Cui, Xiaolei, et al.
(author)
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Temperature-dependent electronic properties of inorganic-organic hybrid halide perovskite (CH3NH3PbBr3) single crystal
- 2017
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In: Applied Physics Letters. - : AMER INST PHYSICS. - 0003-6951 .- 1077-3118. ; 111:23
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Journal article (peer-reviewed)abstract
- In this paper, the temperature-dependent electronic properties of inorganic-organic hybrid halide perovskite (CH3NH3PbBr3) single crystals are investigated. The dynamic current-time measurement results at different temperatures directly demonstrate that the electrical properties of the perovskite single crystal are dependent on the work temperature. We find that the Poole-Frankel conduction mechanism fits the current-voltage curves at small bias voltage (0-1 V) under darkness, which is mainly attributed to the surface defect states. The capability of carriers de-trapping from defects varies with different work temperatures, resulting in an increased current as the temperature increases under both darkness and illumination. In addition, the different transient photocurrent responses of incident light at two wavelengths (470 nm, 550 nm) further confirm the existence of defect states on the single crystal surface. Published by AIP Publishing.
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- Ding, Shaozhen, et al.
(author)
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novoPathFinder: a webserver of designing novel-pathway with integrating GEM-model
- 2020
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In: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 48:W1, s. W477-W487
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Journal article (peer-reviewed)abstract
- To increase the number of value-added chemicals that can be produced by metabolic engineering and synthetic biology, constructing metabolic space with novel reactions/pathways is crucial. However, with the large number of reactions that existed in the metabolic space and complicated metabolisms within hosts, identifying novel pathways linking two molecules or heterologous pathways when engineering a host to produce a target molecule is an arduous task. Hence, we built a user-friendly web server, novoPathFinder, which has several features: (i) enumerate novel pathways between two specified molecules without considering hosts; (ii) construct heterologous pathways with known or putative reactions for producing target molecule within Escherichia coli or yeast without giving precursor; (iii) estimate novel pathways with considering several categories, including enzyme promiscuity, Synthetic Complex Score (SCScore) and LD50 of intermediates, overall stoichiometric conversions, pathway length, theoretical yields and thermodynamic feasibility. According to the results, novoPathFinder is more capable to recover experimentally validated pathways when comparing other rule-based web server tools. Besides, more efficient pathways with novel reactions could also be retrieved for further experimental exploration. novoPathFinder is available at http://design.rxnfinder.org/novopathfinder/.
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- Duan, Dongban, et al.
(author)
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Gadolinium Neutron Capture Reaction-Induced Nucleodynamic Therapy Potentiates Antitumor Immunity
- 2023
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In: CCS Chemistry. - : Chinese Chemical Society. - 2096-5745. ; 5:11, s. 2589-2602
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Journal article (peer-reviewed)abstract
- A nuclear reaction-induced dynamic therapy, denoted as nucleodynamic therapy (NDT), has been invented that triggers immunogenic cell death and successfully treats metastatic tumors due to its unexpected abscopal effect. Gadolinium neutron capture therapy (GdNCT) is binary radiotherapy based on a localized nuclear reaction that produces high-energy radiations (e.g., Auger electrons, γ-rays, etc.) in cancer cells when 157Gd is irradiated with thermal neutrons. Yet, its clinical application has been postponed due to the poor ability of Auger electrons and γ-rays to kill cells. Here, we engineered a 157Gd-porphyrin framework that synergizes GdNCT and dynamic therapy to efficiently produce both •OH and immunogenic 1O2 in cancer cells, thereby provoking a strong antitumor immune response. This study unveils the fact and mechanism that NDT heats tumor immunity. Another unexpected finding is that the Auger electron can be the most effective energy-transfer medium for radiation-induced activation of nanomedicines because its nanoscale trajectory perfectly matches the size of nanomaterials. In mouse tumor models, NDT causes nearly complete regression of both primary and distant tumor grafts. Thus, this 157Gd-porphyrin framework radioenhancer endows GdNCT with the exotic function of triggering dynamic therapy; its application may expand in clinics as a new radiotherapy modality that utilizes GdNCT to provoke whole-body antitumor immune response for treating metastases, which are responsible for 90% of all cancer deaths.
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- Feng, Wenqing, et al.
(author)
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A novel change detection approach based on visual saliency and random forest from multi-temporal high-resolution remote-sensing images
- 2018
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In: International Journal of Remote Sensing. - : Informa UK Limited. - 0143-1161 .- 1366-5901. ; 39:22, s. 7998-8021
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Journal article (peer-reviewed)abstract
- This article presents a novel change detection (CD) approach for high-resolution remote-sensing images, which incorporates visual saliency and random forest (RF). First, highly homogeneous and compact image super-pixels are generated using super-pixel segmentation, and the optimal segmentation result is obtained through image superimposition and principal component analysis. Second, saliency detection is used to guide the search of interest regions in the initial difference image obtained via the improved robust change vector analysis algorithm. The salient regions within the difference image that correspond to the binarized saliency map are extracted, and the regions are subject to the fuzzy c-means (FCM) clustering to obtain the pixel-level pre-classification result, which can be used as a prerequisite for super-pixel-based analysis. Third, on the basis of the optimal segmentation and pixel-level pre-classification results, different super-pixel change possibilities are calculated. Furthermore, the changed and unchanged super-pixels that serve as the training samples are automatically selected. The spectral features and Gabor features of each super-pixel are extracted. Finally, super-pixel-based CD is implemented by applying RF based on these samples. Experimental results on Quickbird, Ziyuan 3 (ZY3), and Gaofen 2 (GF2) multi-spectral images show that the proposed method outperforms the compared methods in the accuracy of CD, and also confirm the feasibility and effectiveness of the proposed approach.
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10. |
- Feng, Wenqing, et al.
(author)
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A novel change detection approach for multi-temporal high-resolution remote sensing images based on rotation forest and coarse-to-fine uncertainty analyses
- 2018
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In: Remote Sensing. - : MDPI AG. - 2072-4292. ; 10:7
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Journal article (peer-reviewed)abstract
- In the process of object-based change detection (OBCD), scale is a significant factor related to extraction and analyses of subsequent change data. To address this problem, this paper describes an object-based approach to urban area change detection (CD) using rotation forest (RoF) and coarse-to-fine uncertainty analyses of multi-temporal high-resolution remote sensing images. First, highly homogeneous objects with consistent spatial positions are identified through vector-raster integration and multi-scale fine segmentation. The multi-temporal images are stacked and segmented under the constraints of a historical land use vector map using a series of optimal segmentation scales, ranging from coarse to fine. Second, neighborhood correlation image analyses are performed to highlight pixels with high probabilities of being changed or unchanged, which can be used as a prerequisite for object-based analyses. Third, based on the coarse-to-fine segmentation and pixel-based pre-classification results, change possibilities are calculated for various objects. Furthermore, changed and unchanged objects identified at different scales are automatically selected to serve as training samples. The spectral and texture features of each object are extracted. Finally, uncertain objects are classified using the RoF classifier. Multi-scale classification results are combined using a majority voting rule to generate the final CD results. In experiments using two pairs of real high-resolution remote sensing datasets, our proposed approach outperformed existing methods in terms of CD accuracy, verifying its feasibility and effectiveness.
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