| 1. |
- Lindell, Lina, 1977-, et al.
(author)
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Journey to the destination: a circular tourism economy : a training program for the hospitality industry to facilitate a transition towards increased circularity in the South Baltic Region
- 2019
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Reports (other academic/artistic)abstract
- Being aware of the extent of the tourism industry and that it is ever growing, which is also encouraged in many individual countries by the national and regional governments, it is evident that the tourism industry is an essential target group for introducing circular concepts and implementing circular solutions. Yet, this sector has so far received little attention in the literature and initiatives on circularity.Circular Economy (CE) goes beyond “green” or “environmental”, it includes all aspects of a community and challenges us to create solutions that are completely different from what we are used to. It also invites us to open up and interact with other stakeholders and the general public.In your hands is the first training material in circular economy specifically developed for small to medium sized companies of the tourism industry in the South Baltic Region. It is a small but important step in the direction towards circularity and a wellbeing society. Through this work we have shown that despite cultural challenges and regional differences there is a shared, common interest in making tourism more sustainable and even to work together towards a transformation of the hospitality industry. This common vision has been stronger than the challenges we faced in making this work and this is what will ensure the continued growing awareness on circularity and its integration in different sectors in our communities. In this work we have featured some of the groundbreaking experts in this field, and some of the first good practices from our regions. They are all courageous pioneers in a field that with time will become the norm. In fact, in the 10th Annual Forum of the EU strategy for the Baltic Sea Region (12-13/6/2019, Gdansk, Poland), CE was highlighted as the pathway to reach prosperity and wellbeing in the Baltic Sea Region.
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| 2. |
- Svensson, Arne, et al.
(author)
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Utvärdering av Kunskapsprogrammet Hållbar Sanering
- 2009
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Reports (other academic/artistic)abstract
- Kunskapsprogrammet Hållbar Sanering är en del av Naturvårdsverkets arbete med att nå miljömålet Giftfri miljö. Genom Hållbar Sanering har myndigheter, forskare och företag fått bidrag för att bygga upp och sprida kunskap om efterbehandling av förorenade mark- och vattenområden. Via Naturvårdsverkets hemsida kan all tillgänglig information inhämtas om kunskapsprogrammet Hållbar Sanering, inklusive samtliga projektrapporter och resultatet av syntesarbetet. Totalt har i kunskapsprogrammet genom tre utlysningar 2004 - 2006 finansierat 54 projekt (56 rapporter) inom områdena Undersökningsmetoder, Riskbedömning, Riskvärdering, Riskkommunikation och Åtgärdslösningar. Närmare hälften av projekten avser riskbedömning. En utvärdering har på Naturvårdsverkets uppdrag genomförts av Professional Management AB under perioden januari – april 2009. Utvärderingen visar att Hållbar Sanering har gjort en betydande insats för kunskapsförsörjningen, särskilt när det gäller riskbedömning och riskvärdering. Den ena utvärderingsfrågan handlar om i vilken utsträckning kunskapsprogrammets syfte har uppnåtts. Enligt 70 % av respondenterna i de primära målgrupperna (Naturvårdsverket, SGI, SGU, länsstyrelser, konsulter, forskare och forskningsfinansiärer) har syftet med Hållbar Sanering uppnåtts helt, nästan helt eller i stor utsträckning. Genom kunskapsprogrammet Hållbar Sanering har branschen fått ny kunskap och resultat kan användas i arbetet med att efterbehandla förorenad mark. Det finns en bred samstämmighet bland respondenterna om att Hållbar Sanering har gett användbara resultat för målgrupperna. Nio av tio instämmer helt eller delvis i att Hållbar Sanering erbjuder kunskap och resultat till nytta för myndigheter, forskare och företag. Närmare tre fjärdedelar av respondenterna har redan i viss eller betydande utsträckning själva använt resultatet från Hållbar Sanering i sitt arbete. Tre fjärdedelar anger även att de har haft stor nytta eller viss nytta av dessa resultat. Det bör noteras att denna utvärdering har genomförts innan kunskapsprogrammet är helt avslutat. Det är därför för tidigt att förvänta sig full effekt av programmet. Trots detta kan således påvisas att programmet redan har skapat verifierbar nytta hos målgrupperna. Den andra utvärderingsfrågan gäller arbetssättet. Två av tre respondenter i de primära målgrupperna anser att arbetssättet i stor eller mycket stor utsträckning har varit ändamålsenligt för att öka kunskapen. Färre bedömer dock att arbetssättet hittills har varit ändamålsenligt för att ge underlag för att prioritera insatser. I detta avseende är det bara 28 % som anser att arbetssättet i stor eller mycket stor utsträckning har varit ändamålsenligt. Detta kan möjligen sammanhänga med att tyngdpunkten i kunskapsprogrammet har legat på projekt som gäller riskbedömning och riskvärdering medan få projekt har gällt åtgärdslösningar. För att kunna göra prioriteringar krävs att det går att ställa kostnadseffektiviteten i olika åtgärdslösningar mot varandra. Här uppfattas Hållbar Sanering inte ha bidragit med det underlag som är nödvändigt för beslutsfattarna. Syntesarbetet har dock lett fram till att Naturvårdsverket vet inom vilka områden (inom ramen för programmets kunskapsområden) det finns ytterligare kunskapsbehov. En eventuell fortsatt satsning bör inriktas mot åtgärdslösningar. Samtliga intressenter som har medverkat i arbetet gör bedömningen att kunskapsprogrammet Hållbar Sanering har fokuserats på rätt områden och att områden med viktiga kunskapsluckor har prioriterats i utlysningarna. Det finns en bra balans mellan tekniska, ekonomiska och samhälleliga aspekter. De projekt som har fått stöd synes ha täckt prioriterade kunskapsluckor inom större delen av dessa områden. Dock skulle det ha funnits behov av mer insatser vad gäller åtgärdstekniker, varför Naturvårdsverket bör överväga att använda en del av anslaget för efterbehandlingsarbetet för en ny projektomgång som tydligt är inriktad mot åtgärdsteknik och annan empiri som inte har täckts av Hållbar Sanering. Medan Hållbar Sanering har haft en bred inriktning bör således en ny utlysning vara betydligt smalare och fokusera på ett fåtal frågeställningar av tillämpningskaraktär. Både programkommittén, projektledaren och beredningsgruppen i övrigt har enligt samstämmiga uppgifter genomfört sitt uppdrag på ett mycket bra sätt. Programkommittén har haft en bred sammansättning, vilket har skapat goda förutsättningar för en gemensam kunskapsutveckling. Dock har representant för konsulterna saknats i programkommittén. Generellt sett har arbetssättet inom kunskapsprogrammet varit ändamålsenligt. Programmet har varit välorganiserat och arbetet har lagts upp på ett målmedvetet sätt. Resultatet är av stort värde för intressenterna. Publiceringen av rapporterna på Naturvårdsverkets hemsida anses ha fungerat bra. Den bristande tidshållningen i vissa av projekten och i syntesarbetet borde dock ha kunnat motverkas genom kraftfullare styrning och tydligare incitament. Vidare kunde programmet ha marknadsförts mera offensivt både i utlysningsfasen och i spridningen av resultaten. Materialet från Hållbar Sanering kommer inte att uppdateras eller på annat sätt ändras efter det att programmet är avslutat, men materialet kommer att finnas tillgängligt för alla intressenter för sökning i Naturvårdsverkets webbibliotek. Därutöver kan det finnas skäl att kontinuerligt sprida riktad information om att materialet som helhet finns och om enskilda rapporter till specifika målgrupper. Vissa rapporter kommer att vara aktuella under längre tid, medan det på andra områden relativt snabbt kan komma fram ny kunskap. Naturvårdsverket bör därför systematiskt analysera vad som kan användas som underlag för verkets framtida vägledningsarbete. Beslutsfattare och utförare har behov av tydliga rekommendationer utifrån dagens tillgängliga kunskap. En del av de kunskapsluckor som återstår kan täckas genom internationellt samarbete. Detta gäller inte minst grundläggande studier av föroreningars öde i mark och vatten och olika toxikologiska effekter. Den kunskap som tas fram internationellt kan anpassas till svenska förhållanden och föras vidare av t.ex. forskare (universitet eller forskningsinstitut), konsulter, entreprenörer eller handläggare på en myndighet eller annan organisation. I utvärderingen skisseras också avslutningsvis tre alternativ när det gäller en senare effektstudie.
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| 3. |
- Tyler, Torbjörn, et al.
(author)
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Utsådda blommor räddar inte insekterna
- 2021
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In: Svenska Dagbladet. - 1101-2412.
-
Journal article (pop. science, debate, etc.)abstract
- Om vi vill rädda hotade insektsarter är det miljöer med traditionella ängsväxter som vi behöver mer av, inte fröblandningar av oklart ursprung från handeln. Det skriver flera debattörer.
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| 4. |
- Ahlqvist, Kerstin, et al.
(author)
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Verksamhetsförlagd kompetensutveckling
- 2024
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In: Högskolepedagogisk debatt. - : Kristianstad University Press. - 2000-9216. ; 2023:2, s. 43-54
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Journal article (other academic/artistic)abstract
- Delaktighet och engagemang är centrala begrepp som vi på Högskolan Kristianstad (HKR) delar med Kristianstad kommun för att marknadsföra staden. Kan verksamhetsförlagd kompetensutveckling (VFK) bli det som förenar oss i en samverkan för att utveckla våra utbildningar och få engagerade lärare och studenter?
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| 5. |
- Ainsworth, Richard I, et al.
(author)
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Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function.
- 2022
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
-
Journal article (peer-reviewed)abstract
- Rheumatoid arthritis (RA) is an immune-mediated disease affecting diarthrodial joints that remains an unmet medical need despite improved therapy. This limitation likely reflects the diversity of pathogenic pathways in RA, with individual patients demonstrating variable responses to targeted therapies. Better understanding of RA pathogenesis would be aided by a more complete characterization of the disease. To tackle this challenge, we develop and apply a systems biology approach to identify important transcription factors (TFs) in individual RA fibroblast-like synoviocyte (FLS) cell lines by integrating transcriptomic and epigenomic information. Based on the relative importance of the identified TFs, we stratify the RA FLS cell lines into two subtypes with distinct phenotypes and predicted activepathways. We biologically validate these predictions for the top subtype-specific TF RARα and demonstrate differential regulation of TGFβ signaling in the two subtypes. This study characterizes clusters of RA cell lines with distinctive TF biology by integrating transcriptomic and epigenomic data, which could pave the way towards a greater understanding of disease heterogeneity.
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| 6. |
- Alsterholm, Mikael, 1977, et al.
(author)
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Establishment and utility of SwedAD : a nationwide Swedish registry for patients with atopic dermatitis receiving systemic pharmacotherapy
- 2023
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In: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 103
-
Journal article (peer-reviewed)abstract
- SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characteristics at enrolment included median Eczema Area and Severity Index (EASI) 10.2 (interquartile range 4.0, 19.4), Patient-Oriented Eczema Measure (POEM) 18.0 (10.0, 24.0), Dermatology Life Quality Index (DLQI) 11.0 (5.0, 19.0) and Peak Itch Numerical Rating Scale-11 (NRS-11) 6.0 (3.0, 8.0). At 3 months, median EASI was 3.2 (1.0, 7.3) and POEM, DLQI, and NRS-11 were improved. Regional coverage varied, reflecting the distribution of dermatologists, the ratio of public to private healthcare, and difficulties in recruiting certain clinics. This study highlights the importance of a nationwide registry when managing systemic pharmacotherapy of atopic dermatitis.
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| 7. |
- Asnicar, Davide, et al.
(author)
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Sand Goby : An Ecologically Relevant Species for Behavioural Ecotoxicology
- 2018
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In: Fishes. - : MDPI. - 2410-3888. ; 3:1
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Journal article (peer-reviewed)abstract
- Locomotion-based behavioural endpoints have been suggested as suitable sublethal endpoints for human and environmental hazard assessment, as well as for biomonitoring applications. Larval stages of the sand goby (Pomatoschistus minutus) possess a number of attractive qualities for experimental testing that make it a promising species in behavioural ecotoxicology. Here, we present a study aimed at developing a toolkit for using the sand goby as novel species for ecotoxicological studies and using locomotion as an alternative endpoint in toxicity testing. Exposure to three contaminants (copper (Cu), di-butyl phthalate (DBP) and perfluorooctanoic acid (PFOA) was tested in the early life stages of the sand goby and the locomotion patterns of the larvae were quantified using an automatic tracking system. In a photo-motor test, sand goby larvae displayed substantially higher activity in light than in dark cycles. Furthermore, all tested compounds exerted behavioural alterations, such as hypo- and hyperactivity. Our experimental results show that sand goby larvae produce robust and quantifiable locomotive responses, which could be used within an ecotoxicological context for assessing the behavioural toxicity of environmental pollutants, with particular relevance in the Nordic region. This study thus suggests that sand goby larvae have potential as an environmentally relevant species for behavioural ecotoxicology, and as such offer an alternative to standard model species.
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| 8. |
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| 9. |
- Bontekoe, Eelke, et al.
(author)
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Deliverable 9.5: Report on monitoring framework in LH cities and established baseline
- 2020
-
Reports (other academic/artistic)abstract
- The IRIS project has defined goals and targets in the project proposal, and the monitoring and evaluation work package (WP) 9 will analyse to what extent the project reaches these goals and objectives. The monitoring and evaluation will also provide information concerning the performance of the different solutions demonstrated in the Lighthouse (LH) cities in IRIS which is important for the replication of the solutions both in the LH cities and in other cities. This is of importance for the replicability of the solutions, both in the LH cities (Utrecht, Nice and Gothenburg) and in other cities. The project consists of several demonstration projects which are divided by 5 transition tracks (TTs): TT1; Smart renewables and closed- loop energy positive districts, TT2; Smart Energy Management and Storage for Grid Flexibility, TT3; Smart e-Mobility Sector, TT4; City Innovation Platform (CIP) Use Cases, TT5; Citizen engagement and co-creation.D9.5 is the result of 2 years of work with several iterative processes involving the LH cities and their partners with the ultimate goal to:Define a set of Key Performance Indicators (KPIs) which evaluate the effectiveness and impact of the cities proposed measures.Setup monitoring plans for each IS to define how each parameter is being measured to ensure that the KPIs can be calculated.Define how the baseline and the targets are defined and measured.This work started as described in D9.2 (Report on monitoring and evaluation schemes for integrated solutions) [1] with:The definition of the initial list of KPIs and how to calculate them, based on Smart Cities Information System (SCIS) [2], the CITYKeys Project [3] and the IRIS project itself .The assignment of KPIs to relevant measures within the project.An evaluation plan to measure performance on project level, including aggregation of KPIs.The process has continued with D9.3 (Report on data model and management plan for integrated solutions) [4] and D9.4 (Report on unified framework for harmonized data gathering, analysis and reporting) [5], which define the basis of the methodologies used to come to the results written in this report.Feedback from several workshops on this topic has led to a guideline that supports the partners responsible for implementation of the demonstrators in setting up their projects such that:KPIs that are being measured are well understood.KPIs give a meaningful result.The right data is being measured to calculate the required KPIs during the implementation of the measures.An important part of this process is to have a close look at the KPIs that are projected for each demonstrator, the calculation method of the KPIs, and the expected results. By means of KPI interpretation forms. By doing so:• KPIs are defined and calculated such that only one way of interpretation is possible. This way results from different projects and cities are homogenized.• It is well understood what result the measurement of a KPI leads to.The method and results of this process are described in this report, which is a revised KPI list where KPIs are added, removed or adapted.In addition to this, the KPI interpretation forms created the basis for the formulation of detailed monitoring plans for all measures within the project. Together with template forms for reporting these plans and a common data structure, which were provided to the affiliated partners, these plans are obtained and described for all measures per Transition Track and per Lighthouse city in this report.Another essential part of measuring the performance of the IRIS project is the establishment of the baseline measurements and review if targets are met. Tables with KPI data requirements, consisting of the associated parameters, data sources, baseline and (possible) targets for all measures are incorporated.An important part of the monitoring strategy of the IRIS project is the KPI tool, which is described in detail in report D9.4 [5]. This tool is established to collect all relevant monitoring data from the IRIS project in order to calculate and visualize the performance of the project. The tool partly obtains it’s data by means of the City Information Platforms (CIP). The monitoring details combined with the updated KPIs, result in an inventory containing an overview of all data sources with as main objective:• To make sure that all data sources are known and will be measured by the responsible partners.• To know what kind of data needs to be collected by the KPI tool.• To know when monitoring in each demonstrator starts and data can be expected.• To have a clear overview for all responsible partners what to deliver.Besides setting up the collection of the indicators data, D9.5 also continues the work on aggregation of KPIs. For each city a revised list is made that indicates which KPIs will be aggregated to Transition Track-, City- and IRIS-level.In the conclusion the challenges that where met during the process of setting up the monitoring framework are described. Because of delays within the IRIS project, not all monitoring plans have been obtained yet. Therefore, a future update of this report will be submitted as soon as this information is available. Further on a perspective is described for future work to start gathering the data and visualize results of the IRIS project.The target group for this report is mainly people who:- Are interested in how to apply a unified monitoring and evaluation scheme into a large Smart City project with many different partners and stakeholders. For example, people working on comparable (Smart City) projects, or the follower cities within the IRIS project.- Are interested in how the performance of several different Smart city projects can be evaluated.- Are interested in the implementation of KPIs from projects such as SCIS and CITYkeys.- Want to learn from project partners from within the IRIS project who work on similar projectsabout their monitoring. For example, partners from different cities affiliated with the same transition track or transition track leaders.- Want to find out what kind of data can be expected from the IRIS project. For example, external researchers interested in the results of Smart City projects, but also partners working on WP4 (CIP) and WP9 (monitoring and evaluation).Want to learn what the current state is of the monitoring and evaluation of the IRIS project.
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| 10. |
- Cotgreave, Ian A, et al.
(author)
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Differentiation-specific alterations to glutathione synthesis in and hormonally stimulated release from human skeletal muscle cells.
- 2002
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In: The FASEB Journal. - : Wiley. - 0892-6638 .- 1530-6860. ; 16:3, s. 435-7
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Journal article (peer-reviewed)abstract
- Muscle atrophy and cachexia are associated with many human diseases. These catabolic states are often associated with the loss of glutathione (GSH), which is thought to contribute to the induction of oxidative stress within the muscle. Glutathione synthesis and secretary characteristics were studied in human skeletal muscle myoblasts and myotube-like cells derived from the myoblasts by growth factor restriction. Differentiation was associated with a shift in the sulfur amino acid precursor specificity for synthesis of GSH from cystine to cysteine, as well as loss in ability to use extracellular glutathione and activation of methionine use. The thiol drug N-acetylcysteine was also shown to be an effective precursor irrespective of the state of differentiation. Additionally, myoblasts and myotube cultures were shown to secrete GSH continually, but only the differentiated cells responded to stress hormones such as glucagon, vasopressin, and phenylephrine, by increased secretion of the tripeptide. The data suggest that the skeletal muscle cells may provide an important hormonally regulated extra-hepatic source of systemic GSH and also shed light on the mechanisms of accelerated turnover of GSH operating during strenuous muscle activity and trauma. The data may also provide biochemical rationales for the nutritional and/or pharmacological manipulation of GSH with sulfur amino acid precursors during the treatment of muscle-specific oxidative stress and atrophy.
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