| 1. |
- Bouw, R., et al.
(author)
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Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis
- 2001
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In: Acta Anaesthesiologica Scandinavica. - : Wiley. - 0001-5172. ; 45, s. 390-
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Journal article (peer-reviewed)abstract
- Intracerebral microdialysis was utilised to obtain information regarding how morphine is transported across the blood-brain barrier (BBB). In a patient with a severe brain injury, we measured simultaneously unbound extracellular fluid (ECF) concentrations of morphine in human brain and in subcutaneous fat tissue, which were compared to morphine levels in arterial blood. This report shows an increase in morphine levels near the trauma site in the brain compared to uninjured brain tissue. The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, respectively, were comparable but were longer than in blood (64 min) and adipose tissue (63 min). This indicates that morphine is retained in brain tissue for a longer time than what could be expected from the blood concentration-time profile. These results show the potential of the microdialysis technique in providing new information regarding the pharmacokinetics of drug in the human brain close to the trauma site and in macroscopically intact tissue.
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| 2. |
- Carlström, Jesper
(author)
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Wheels - on division by zero
- 2004
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In: Mathematical Structures in Computer Science. - 0960-1295. ; 14:1, s. 143-184
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Journal article (peer-reviewed)
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| 3. |
- Foberg, U, et al.
(author)
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Viral haemorrhagic fever in Sweden : experiences from management of a case.
- 1991
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In: Scandinavian Journal of Infectious Diseases. - 0036-5548 .- 1651-1980. ; 23:2, s. 143-151
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Journal article (peer-reviewed)abstract
- The first recognized case in Scandinavia with potential man to man transmission of viral haemorrhagic fever occurred in Linköping, Sweden, in January 1990. Following a visit to Kenya a 21-year-old male student suffered a very severe illness including extremely prolonged high grade fever, rash, disseminated intravascular coagulation with thrombocytopenia and severe bleedings. This necessitated one month of intensive care support including respirator treatment. The patient was discharged after 2 1/2 months in good condition, with a partial femoral nerve paresis. About 100 medical personnel were exposed to aerosol or blood before a strict containment regimen was established. No secondary cases occurred.
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| 4. |
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| 5. |
- Skovdahl, Pia, et al.
(author)
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Physical activity in children and adolescents with CHD: Review from a measurement methodological perspective
- 2021
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In: Cardiology in the Young. - 1047-9511. ; 31:4
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Journal article (peer-reviewed)abstract
- Aim: To compile a literature overview of physical activity in children with CHD and to critically evaluate the methodology used for physical activity assessment. Methods: A review of the literature was performed using PubMed to identify studies examining accelerometer and subjectively assessed physical activity in children and adolescents with CHD. Result: A total of 15 studies were included (6 studies using subjective measures and 9 articles using accelerometers for the assessment of physical activity). The patients generally failed to meet the recommendations of physical activity. When compared to healthy controls, the results were widely divergent in the subjectively assessed measures and the accelerometer-based studies showed a tendency of no difference in physical activity. Neither subjective methods nor accelerometer-based studies reported any difference in physical activity in general, in relation to the severity of the heart disease. Conclusion: Methodological variation and limitations in the assessment of physical activity largely explain the divergent results and the inability to establish differences in physical activity between children with CHD of different severity and compared to healthy controls. Methodological knowledge and guidelines are provided for improved assessment of physical activity using accelerometers in clinical research. © The Author(s), 2021. Published by Cambridge University Press.
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