| 1. |
- Svensson, Madeleine, 1983-, et al.
(author)
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Strategies to Encourage E-health : The Effects of Using Different Reminders to Various Extents on Overall Response Patterns in a Large Randomized Internet-based Intervention Study
- 2011
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Conference paper (peer-reviewed)abstract
- BackgroundThe use of the Internet as a research tool has dramatically increased in the past several years. Yet, the current literature favors the response rate achieved from paper-based studies. Knowledge of successful methods to increase participation in Internet-based research is scarce. The objective of this study is to examine the effects of different reminders to encourage study participation on overall response patterns in an Internet-based intervention study.MethodsIn 2008, 3,876 employees at four companies in the railway sector in Sweden were randomly e-mailed an Internet-based lifestyle questionnaire consisting of: A) questions, B) questions + interactive personalized automated feedback, or C) questions + interactive personalized automated feedback + telephone counseling. The questionnaire assessed health aspects including diet, physical activity, sleep, stress, alcohol/tobacco consumption, and motivation to change health. Interactive feedback was provided for all health sections; telephone counseling was offered for diet, physical activity, alcohol and smoking habits. Nine months later, a follow-up questionnaire (C) was e-mailed to examine health improvements. 4-5 and 11 e-mail reminders were sent at baseline and follow-up, respectively. Additional reminders (flyers, texts in internal media/bulletin board, information talks, SMS, visit by the research group etc) were also administered at the four companies, to various extents. The number of additional reminders was summarized and analyses were based on the total number of received additional reminders (low, moderate or high). Response patterns were examined in relation to basic characteristics, company, work type (office/field worker), received e-mail reminders, and total number of received additional reminders. As a result of the study, the companies received recommendations for future health implementations.Results38% and 36% completed the baseline and follow-up questionnaire, respectively. The majority of the participants was male, non-smokers, employed as field workers, and had a BMI ≥25. The 4-5 e-mail reminders increased the total response rate by 15%; the 11 e-mail reminders by 21%. Additional reminders had a marginal effect on total response rate, yet generated a positive effective on the response rate among office workers (71%). Since the planning process of the study, the company involved had the highest overall response rate (61%: P<0.001), despite receiving a moderate number of additional reminders. The employees at this company were almost 1.80 (CI: 1.55-2.08) times more likely to participate in the baseline questionnaire, compared to the company which entered the study just prior to the start and had the lowest overall response rate. Participant characteristics including sex, age, BMI, smoking, motivation to change health habits, and version of the completed questionnaire (A, B or C) were not associated with time of response. The highest participation at follow-up, however, was found for those who completed baseline questionnaire A, consisting solely of questions.ConclusionsA well-established collaboration with the participants prior to study start and to send out e-mail reminders on a continuous basis are two effective strategies to increase the response rate in Internet-based studies. Additional reminders conducted in the work setting may only be effective among office workers participating in Internet-based studies.
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| 2. |
- Svensson, Madeleine, 1983-, et al.
(author)
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The effect of reminders in a web-based intervention study
- 2012
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In: European Journal of Epidemiology. - Dordrecht : Springer Netherlands. - 0393-2990 .- 1573-7284. ; 27:5, s. 333-340
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Journal article (peer-reviewed)abstract
- Knowledge on effective strategies to encourage participation in epidemiological web-based research is scant. We studied the effects of reminders on overall participation. 3,876 employees were e-mailed a baseline web-based lifestyle questionnaire. Nine months later, a follow-up questionnaire was sent. To encourage study participation, 4–5 and 11 e-mail reminders were sent at baseline and follow-up, respectively. Additional reminders (media articles, flyers, SMS etc) were also administered. Reminders (e-mails + additional) were given in low (≤6 reminders), medium (7–9 reminders) or high amounts (>9 reminders). Participation was examined with respect to participant characteristics (i.e. age, sex, Body Mass Index, occupation), type/number of reminders, and time of participation. Most participants were males, 35–49 years, and field workers (non-office based). About 29 % responded before any e-mail reminder, following 26 and 45 % after 1 respective ≥ 2 e-mail reminders. Participant characteristics were not related to when the participants responded. The 4–5 e-mail reminders increased total response rate by 15 %, the eleven by 21 % (greatest increases in September). Those receiving medium amounts of reminders (reference) had the highest response rate (75 %), likewise office workers (54 %) compared to field workers (33 %). High amounts of reminders were particularly effective on office workers. The participants’ characteristics were not related to when they responded in this web-based study. Frequent reminders were effective on response rates, especially for those with high Internet availability. The highest increases in response rates were found in September. © The Author(s) 2012.
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| 3. |
- Bergdahl, Johan, et al.
(author)
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Evaluation of an algorithm ascertaining cases of osteonecrosis of the jaw in the Swedish National Patient Register
- 2013
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In: Clinical Epidemiology. - Macclesfield : Dove Medical Press Ltd.. - 1179-1349. ; 5:1, s. 1-7
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Journal article (peer-reviewed)abstract
- Background: Osteonecrosis of the jaw (ONJ) is a medical condition associated with antiresorptive drugs, among others, used to treat osteoporosis and bone metastasis. Currently, there is no consensus regarding the definition of ONJ, and no ONJ-specific International Classification of Diseases-10 code exists. Therefore, register-based studies of this condition may be troublesome.Purpose: To evaluate an algorithm ascertaining ONJ cases in an attempt to facilitate future assessments of ONJ in clinical and epidemiological studies.Methods: By means of the Patient Register and the Prescribed Drug Register, we identified all postmenopausal female residents in Sweden from 2005 through 2009. To identify potential cases of ONJ, we employed an algorithm including the following conditions: periapical abscess with sinus, inflammatory conditions of jaws, alveolitis of jaws, idiopathic aseptic necrosis of bone, osteonecrosis due to drugs, osteonecrosis due to previous trauma, other secondary osteonecrosis, other osteonecrosis, and unspecified osteonecrosis. Women seen at departments of oral and maxillofacial surgery, with at least one of the conditions, were classified as potential cases of ONJ. Conditions in anatomic sites other than the jaw were excluded. Validation was performed through medical record review. Case confirmation was based on the ONJ definition by the American Association of Oral and Maxillofacial Surgeons. The algorithm was evaluated by positive predictive values (PPVs) stratified by diagnosis.Results: For the 87 potential cases identified through our algorithm, the medical records were obtained for 83. The overall PPV was 18% (95% confidence interval (CI) 10%–28%). The highest PPV was observed in osteonecrosis due to drugs (83%, 95% CI 36%–100%). Several diagnoses had a PPV of 0 or were not used at all (periapical abscess with sinus, alveolitis of jaws, idiopathic aseptic necrosis of bone, osteonecrosis due to previous trauma, other secondary osteonecrosis, other osteonecrosis, and unspecified osteonecrosis).Conclusion: It was possible to ascertain cases of ONJ from the Swedish registers using this algorithm; however, the PPV was low. Thus, further refinements of the algorithm are necessary. © 2013 Bergdahl et al, publisher and licensee Dove Medical Press Ltd.
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| 4. |
- Fernström, Maria, 1960-, et al.
(author)
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Improved Muscle Mitochondrial Capacity Following Gastric Bypass Surgery in Obese Subjects
- 2016
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In: Obesity Surgery. - New York, USA : Springer. - 0960-8923 .- 1708-0428. ; 26:7, s. 1391-1397
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Journal article (peer-reviewed)abstract
- Background: Weight loss resulting from low-calorie diets is often less than expected. We hypothesized that energy restriction would influence proton leakage and improve mitochondrial efficiency, leading to reduced energy expenditure, partly explaining the difficulties in weight loss maintenance.Methods: Eleven women with a median BMI of 38.5 kg/m(2) (q-range 37-40), and referred to gastric bypass surgery participated. Before surgery, and at 6 months of follow-up, muscle biopsies were collected from the vastus lateralis muscle. Mitochondria were isolated and analyzed for coupled (state 3) and uncoupled (state 4) respiration and mitochondrial capacity (P/O ratio).Results: At follow-up, the participants had a median BMI of 29.6 kg/m(2) (28.3-32.0). State 3 increased from 20.6 (17.9-28.9) to 34.9 nmol O2/min/U citrate synthase (CS) (27.0-49.0), p = 0.01, while state 4 increased from 2.8 (1.8-4.2) to 4.2 nmol O2/min/U CS (3.1-6.1), although not statistically significant. The P/O ratio increased from 2.7 (2.5-2.8) to 3.2 (3.0-3.4), p = 0.02, indicating improved mitochondrial efficiency.Conclusions: Six months after gastric bypass surgery, the mitochondrial capacity for coupled, i.e., ATP-generating, respiration increased, and the P/O ratio improved. Uncoupled respiration was not enhanced to the same extent. This could partly explain the decreased basal metabolism and the reduced inclination for weight loss during energy restriction.
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| 8. |
- Svensson, Madeleine, 1983-, et al.
(author)
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The Change in Eating Behaviors in a Web-Based Weight Loss Program : A Longitudinal Analysis of Study Completers
- 2014
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In: Journal of Medical Internet Research. - Toronto, ON : Journal of Medical Internet Research. - 1438-8871. ; 16:11
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Journal article (peer-reviewed)abstract
- Background: Eating behaviors are essential components in weight loss programs, but limited research has explored eating behaviors in Web-based weight loss programs.Objectives: The aim was to evaluate an interactive Web-based weight loss program on eating behaviors using the 18-item Three-Factor Eating Questionnaire Revised (TFEQ-R18) which measures uncontrolled eating, emotional eating, and cognitive restrained eating. Our Web-based weight loss program is comprised of information about healthy lifestyle choices, weekly chats with experts, social networking features, databases for recipe searches, and features allowing members to self-report and track their weight, physical activity, and dietary intake on the website.Methods: On registering for the weight loss program, 23,333 members agreed to take part in the research study. The participants were then asked to complete the TFEQ-R18 questionnaire at baseline and after 3 and 6 months of participation. All data collection was conducted online, with no face-to-face contact. To study changes in TFEQ-R18 eating behaviors we restricted our study to those members who completed all 3 TFEQ-R18 questionnaires. These participants were defined as "completers" and the remaining as "noncompleters." The relationships between sex, change in eating behaviors, and total weight loss were studied using repeated measures ANOVA and Pearson correlation coefficient.Results: In total, 22,800 individuals participated (females: 19,065/22,800, 83.62%; mean age 39.6, SD 11.4 years; BMI 29.0 kg/m2; males: 3735/22,800, 16.38%; mean age 43.2, SD 11.7 years; BMI 30.8 kg/m2). Noncompleters (n=22,180) were younger and reported a lower score of uncontrolled eating and a higher score of cognitive restrained eating. Over time, completers (n=620) decreased their uncontrolled eating score (from 56.3 to 32.0; P<.001) and increased their cognitive restrained eating (from 50.6 to 62.9; P<.001). Males decreased their emotional eating (from 57.2 to 35.9; P<.001), but no significant change was found among females. The baseline cognitive restrained eating score was significantly and positively associated with weight loss for completers in both men (P=.02) and women (P=.002).Conclusions: To our knowledge, this is the largest TFEQ sample that has been documented. This Web-based weight loss intervention suggests that eating behaviors (cognitive restrained eating, uncontrolled eating, and emotional eating) measured by TFEQ-R18 were significantly changed during 6 months of participation. Our findings indicate differences in eating behaviors with respect to sex, but should be interpreted with caution because attrition was high.
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| 10. |
- van der Mark, Marianne, et al.
(author)
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Older Members Perform Better in an Internet-Based Behavioral Weight Loss Program Compared to Younger Members
- 2009
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In: Obesity Facts. - Basel : S. Karger. - 1662-4025 .- 1662-4033. ; 2:2, s. 74-79
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Journal article (peer-reviewed)abstract
- Background: New technology offers increased opportunities for weight control. However, it is not clear whether older people with less computer training can make use of this tool. Our objective was to examine how members above the age of 65 years performed in an internet-based behavioral weight loss program, compared to younger members. Methods: Data from members (n = 23,233) of an internet-based behavioral weight loss program were analyzed. We restricted our study to active participants accessing the weight club, during a 6-month period (n = 4,440). The number of logins, food intake, and weight records were examined. Participants were divided into age tertiles separately for men and women. The oldest tertile was further subdivided into two groups: above and below the age of 65 years. Results: Participants aged 65 or older were more likely to remain active in the weight club for at least 6 months compared to younger age groups. They had the highest frequency of recordings of food intake and current weight. Among women, those older than 65 years had on average the highest percentage of weight loss (5.6 kg, 6.8%). Men above 65 years of age had the highest number of logins, on average 161 times during the 6-month period. Conclusion: Older participants are performing equally well or even better in an internet-based behavioral weight loss program than younger participants. Internet-based programs could be a promising and attractive option for older adults requiring assistance in losing weight. © 2009 S. Karger AG, Basel.
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