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- Tai, F, et al.
(author)
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Abdominal Wall Miscellaneous
- 2015
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In: Hernia : the journal of hernias and abdominal wall surgery. - 1248-9204. ; 19 Suppl 1, s. S5-S12
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Journal article (peer-reviewed)
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- Li, Q., et al.
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Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
- 2021
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27, s. 1941-1953
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Journal article (peer-reviewed)abstract
- Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both adipocyte progenitor differentiation and mature adipocyte cell size. Adipocytes, however, are thought to be unable to divide or enter the cell cycle. We demonstrate that mature human adipocytes unexpectedly display a gene and protein signature indicative of an active cell cycle program. Adipocyte cell cycle progression associates with obesity and hyperinsulinemia, with a concomitant increase in cell size, nuclear size and nuclear DNA content. Chronic hyperinsulinemia in vitro or in humans, however, is associated with subsequent cell cycle exit, leading to a premature senescent transcriptomic and secretory profile in adipocytes. Premature senescence is rapidly becoming recognized as an important mediator of stress-induced tissue dysfunction. By demonstrating that adipocytes can activate a cell cycle program, we define a mechanism whereby mature human adipocytes senesce. We further show that by targeting the adipocyte cell cycle program using metformin, it is possible to influence adipocyte senescence and obesity-associated adipose tissue inflammation. Studies in mature human adipocytes demonstrate that obesity and hyperinsulinemia can induce reentry into the cell cycle and induce senescence.
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- Källström, Claes, et al.
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Adaptive Autopilots for Large Tankers
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In: 7th Triennial World Congress of the IFAC : A Link Between Science and Applications of Automatic Control, Helsinki, Finland, 12-16 June - A Link Between Science and Applications of Automatic Control, Helsinki, Finland, 12-16 June. - 1474-6670. ; 11:1, s. 477-484
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Conference paper (peer-reviewed)abstract
- The adaptive autopilots are based on velocity scheduling, a self-tuning regulator for steady state course keeping, a high gain turning regulator with variable structure, and a Kalman filter. Results from simulations and full-scale experiments on three different tankers are presented. The autopilots are shown to work excellently under different loads, speed and weather conditions.
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- Källström, Claes G., et al.
(author)
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Adaptive Autopilots for Tankers
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In: Automatica. - : Elsevier BV. - 0005-1098. ; 15:3, s. 241-254
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Journal article (peer-reviewed)abstract
- Two adaptive autopilots for ships are designed, The autopilots are based on velocity scheduling, a self-tuning regulator for steady state course keeping, a high gain turning regulator with variable structure and a Kalman filter.Methods for design of the autopilots are discussed. Results from simulations and full-scale experiments with three different tankers are presented. The autopilots are shown to work excellently under different load, speed, and weather conditions.
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- LeBlanc, K, et al.
(author)
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Quality of Life after Hernia Surgery
- 2015
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In: Hernia : the journal of hernias and abdominal wall surgery. - 1248-9204. ; 19 Suppl 1, s. S127-31
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Journal article (peer-reviewed)
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