| 1. |
- Reynisdottir, Inga, et al.
(author)
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High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer
- 2013
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In: Cancer Medicine. - : Wiley. - 2045-7634. ; 2:4, s. 437-446
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Journal article (peer-reviewed)abstract
- Amplification of 8p12-p11 is relatively common in breast cancer and several genes within the region have been suggested to affect breast tumor progression. The aim of the study was to map the amplified 8p12-p11 region in a large set of breast tumors in an effort to identify the genetic driver and to explore its impact on tumor progression and prognosis. Copy number alterations (CNAs) were mapped in 359 tumors, and gene expression data from 577 tumors (359 tumors included) were correlated with CNA, clinical–pathological factors, and protein expression (39 tumors). 8p12-p11 was amplified in 11.4% of tumors. The smallest region of amplification harbored one full-length gene, ZNF703. ZNF703 mRNA expression was significantly higher in estrogen receptor (ER)-positive than ER-negative tumors (P = 2 × 10−16), a reflection of high expression in luminal tumors. Forty-eight percent of tumors with ZNF703 amplification were luminal B tumors in which the best correlation between DNA copy number and mRNA was seen (P = 1.2 × 10−7) as well as correlation between mRNA and protein expression (P = 0.02). High ZNF703 mRNA correlated with poor survival in patients with ER-positive luminal B tumors (log rank P = 0.04). Furthermore, high ZNF703 mRNA expression correlated with poor outcome in patients with ZNF703 copy number neutral, ER-positive, luminal B tumors (log rank P = 0.004). The results support ZNF703 as the driver gene of the 8p12 amplification and suggest that independent of amplification, high expression of the gene affects prognosis in luminal B tumors.
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| 2. |
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| 3. |
- Duffy, Cian, et al.
(author)
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Introduction : the Romantic Cultures of Infancy
- 2020
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In: Romanticism and the Cultures of Infancy. - Cham : Springer International Publishing. - 9783030504281 - 9783030504298 ; , s. 1-20
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Book chapter (other academic/artistic)
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| 4. |
- Holst-Hansson, Annette
(author)
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On a journey for survival : everyday life during radiation therapy from the perspectives of women with breast cancer and their families
- 2018
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Doctoral thesis (other academic/artistic)abstract
- This thesis focuses on women diagnosed with breast cancer and their familymembers. Since a breast cancer diagnosis and its subsequent treatment are astrenuous experience not only for the woman afflicted but also for her familymembers, this thesis aimed to explore the experiences of everyday life duringradiation therapy from the perspectives of the woman with breast cancer andher family, as well as exploring families’ experiences of participating in shortfamily health conversations (SFamHC).All included studies were interview studies (Papers I, II, III & IV), where 30women (20 in Paper I and 10 in Paper II) with breast cancer, 19 family membersincluding the women with breast cancer (Paper III) and 9 families (PaperIV) were interviewed. The data from the interviews was analysed using qualitativecontent analysis (Papers I & II), a hermeneutical phenomenologicalmethod (Paper III) and thematic analysis (Paper IV). The women’s experiences of breathing adapted radiation therapy (BART)(Paper I) were identified in an overall theme, The breath of life, as the womenexperienced the breathing as a way to influence their treatment andthus their survival. The overall theme could be divided into one main category:Participating in one’s treatment, for good or ill, with four subcategories:Knowing one has done something good, Getting an extra bonus –healthwise, The experience of being in control and Being in a hightechnologyenvironment.Women born in Iraq and the former Yugoslavia, diagnosed with breast cancerand living in Sweden, experienced their everyday life during radiation therapyas a narrow and challenging treatment road to survival (Paper II). Theirexperiences were structured into three categories: Strategies for survival, Keepingup appearances and Staying in control. More focus should be on acknowledgingthe woman behind the diagnosis, regardless of her origin, in order to develop individualised support programmes to help women cope with everydaylife during radiation therapy.The families’ lived experience when a family member is diagnosed withbreast cancer (Paper III) was described as a challenging endeavour to regain anordinary, safe life, hoping to reach a safe haven. The families felt that life as theyknew it had disappeared and they were fumbling in the dark and pursuing balanceby struggling to keep the family together and by maintaining a positive attitude.They were also struggling with guilt and inadequacy, due to their difficultiesin communicating emotional distress and to feeling abandoned by thehealth care professionals.Families’ experiences of participating in short family health conversations(SFamHC) (Paper IV) were identified in four key themes: Bringing everythingout in the open, Being confirmed as an individual and as a family, Gaining anunexpected insight and Timing and context matter. The findings from this thesis can deepen the understanding of what livingwith breast cancer is like, from the perspectives of the women with breast cancerand their families, as well as increasing the understanding of their needs.Their experiences could be described as a journey for survival, a journey thatstarts at the time of diagnosis and that they are still partaking in when concludingtheir radiation therapy treatment. The journey for survival sends themoff into the unknown, where they strive to regain control, balancing betweenhope and despair, experiencing their life as divided into an outer and innerworld and needing support from each other as well as from health care professionals.A possible way to support the women and their family members couldbe to offer them participation in short family health conversations (SFamHC),since these conversations provide them with an opportunity to verbalise andshare their feelings and thoughts. Those participants (Paper IV) who took partin SFamHC felt that their participation in the SFamHC helped them to moveforward and beyond the breast cancer diagnosis.
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| 6. |
- Kraus, Ludwig, et al.
(author)
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Estimating the number of children in households with substance use disorders in Germany
- 2021
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In: Child and Adolescent Psychiatry and Mental Health. - : Springer Science and Business Media LLC. - 1753-2000. ; 15:1
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Journal article (peer-reviewed)abstract
- Background Parental substance misuse is reported to endanger the health and psychological development of children and adolescents. The aim of the present study was to address conceptual and methodological problems in estimating the number of children affected by parental substance misuse (CaPSM) and offer a novel approach based on survey data.Methods Data came from the 2018 German Epidemiological Survey of Substance Abuse (ESA) among 18- to 64-year-olds (n = 9267) and from population statistics. DSM-IV diagnostic criteria were used to assess substance use disorder (SUD) related to tobacco, alcohol, cannabis, cocaine or amphetamine. Based on the number of household members, the number of children below age 18 years and the information on SUD status of the respondent living in this household, the number of children currently living in households with at least one member with SUD was estimated.Results In 2018, there were 13,597,428 children younger than 18 years living in Germany. Of these, 6.9-12.3% (935,522-1,673,103) were estimated to currently live in households where at least one adult had a tobacco use disorder, 5.1-9.2% (688,111-1,257,345) in households where at least one adult had an alcohol use disorder and 0.6-1.2% (87,817-158,401) in households where at least one adult had a disorder related to the use of illicit drugs. The total number of children currently living with SUD adults in their household was estimated at 11.2-20.2% (1,521,495-2,751,796).Conclusions Available estimates are difficult to interpret and to compare due to a lack of clear case definitions and methodological approaches with various biases and limitations. Future estimates need to provide precise case definitions and standard approaches.
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| 7. |
- Laaber, Christoph, et al.
(author)
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Dynamically reconfiguring software microbenchmarks: Reducing execution time without sacrificing result quality
- 2020
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In: ESEC/FSE 2020 - Proceedings of the 28th ACM Joint Meeting European Software Engineering Conference and Symposium on the Foundations of Software Engineering. - New York, NY, USA : ACM. ; , s. 989-1001
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Conference paper (peer-reviewed)abstract
- Executing software microbenchmarks, a form of small-scale performance tests predominantly used for libraries and frameworks, is a costly endeavor. Full benchmark suites take up to multiple hours or days to execute, rendering frequent checks, e.g., as part of continuous integration (CI), infeasible. However, altering benchmark configurations to reduce execution time without considering the impact on result quality can lead to benchmark results that are not representative of the software's true performance. We propose the first technique to dynamically stop software microbenchmark executions when their results are sufficiently stable. Our approach implements three statistical stoppage criteria and is capable of reducing Java Microbenchmark Harness (JMH) suite execution times by 48.4% to 86.0%. At the same time it retains the same result quality for 78.8% to 87.6% of the benchmarks, compared to executing the suite for the default duration. The proposed approach does not require developers to manually craft custom benchmark configurations; instead, it provides automated mechanisms for dynamic reconfiguration. Hence, making dynamic reconfiguration highly effective and efficient, potentially paving the way to inclusion of JMH microbenchmarks in CI.
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| 8. |
- Wibring, Kristoffer, et al.
(author)
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Prehospital factors associated with an acute life-threatening condition in non-traumatic chest pain patients - A systematic review.
- 2016
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 219, s. 373-379
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Journal article (peer-reviewed)abstract
- BACKGROUND: Chest pain is a common symptom among patients contacting the emergency medical services (EMS). Risk stratification of these patients is warranted before arrival in hospital, regarding likelihood of an acute life-threatening condition (LTC).AIM: To identify factors associated with an increased risk of acute LTC among patients who call the EMS due to non-traumatic chest pain.METHODS: Several databases were searched for relevant articles. Identified articles were quality-assessed using the Scottish Intercollegiate Guidelines Network checklists. Extracted data was analysed using a semi-quantitative synthesis evaluating the level of evidence of each identified factor.RESULTS: In total, 10 of 1245 identified studies were included. These studies provided strong evidence for an increased risk of an acute LTC with increasing age, male gender, elevated heart rate, low systolic blood pressure and ST elevation or ST depression on a 12-lead ECG. The level of evidence regarding the history of myocardial infarction, angina pectoris or presence of a Q wave or a Left Bundle Branch Block on the ECG was moderate. The evidence was inconclusive regarding dyspnoea, cold sweat/paleness, nausea/vomiting, history of chronic heart failure, smoking, Right Bundle Branch Block or T-inversions on the ECG.CONCLUSIONS: Factors reflecting age, gender, myocardial ischemia and a compromised cardiovascular system predicted an increased risk of an acute life-threatening condition in the prehospital setting in cases of acute chest pain. These factors may form the basis for prehospital risk stratification in acute chest pain.
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