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Search: WFRF:(Thunberg Lars)

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  • Varnaite, Renata, et al. (author)
  • Magnitude and Functional Profile of the Human CD4(+) T Cell Response throughout Primary Immunization with Tick-Borne Encephalitis Virus Vaccine
  • 2020
  • In: Journal of Immunology. - : AMER ASSOC IMMUNOLOGISTS. - 0022-1767 .- 1550-6606. ; 204:4, s. 914-922
  • Journal article (peer-reviewed)abstract
    • Tick-borne encephalitis (TBE) is a viral infection of the CNS caused by TBE virus. With no specific treatment available, the only protection is a formalin-inactivated whole virus vaccine. Primary immunization with European TBE vaccines, as recommended by the manufacturers, consists of three vaccine doses administered within a 1-y period. Protection from vaccination is believed to be mediated by Abs, yet T cells may also have a protective role. We set out to characterize the human CD4(+) T cell response throughout primary TBE immunization. The responses were evaluated before vaccination and 1 mo after each vaccine dose. A heterogeneous magnitude of CD4(+) T cell-mediated memory responses was observed in regard to lymphoblast expansion and cytokine production (IFN-gamma, IL-2, and TNF), with the highest median magnitude detected after the second dose of vaccine. Stimulation with an overlapping peptide library based on structural TBE virus proteins E and C revealed that CD4(+) T cells concomitantly producing IL-2 and TNF dominated the responses from vaccinees after each vaccine dose, whereas a control cohort of TBE patients responded mainly with all three cytokines. CD107a expression was not upregulated upon peptide stimulation in the vaccinees. However, CD154 (CD40L) expression on cytokine-positive memory CD4(+) T cells significantly increased after the second vaccine dose. Taken together, TBE vaccination induced CD4(+) T cell responses dominated by IL-2 and TNF production together with CD154 upregulation and a lower IFN-gamma response compared with TBE patients. This response pattern was consistent after all three doses of TBE vaccine.
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  • Result 1-10 of 45
Type of publication
journal article (17)
doctoral thesis (9)
reports (8)
conference paper (5)
book (3)
other publication (1)
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research review (1)
licentiate thesis (1)
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Type of content
other academic/artistic (23)
peer-reviewed (21)
pop. science, debate, etc. (1)
Author/Editor
Thunberg, Anna, 1977 (6)
Bligård, Lars-Ola, 1 ... (6)
Osvalder, Anna-Lisa, ... (5)
Engström, Tomas, 195 ... (5)
Medbo, Lars, 1957 (5)
Andersson, Jonas, 19 ... (5)
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Müller, Christian, 1 ... (3)
Wigström, Lars (3)
Boldizar, Antal, 195 ... (3)
Thunberg, Per, 1968- (3)
Kristensson, Bengt (3)
Larsson, Rolf (2)
Öhrström, Lars, 1963 (2)
Westman, Gunnar, 196 ... (2)
Hammar, Lars, 1961 (2)
Bohlin, Lars (2)
Thunberg, Ulf (2)
Lindholm, P (1)
Hasani, Merima, 1978 (1)
Enblad, Gunilla (1)
Hultdin, Magnus (1)
Sundström, Christer (1)
Lindquist, Lars (1)
Ström, Anna, 1976 (1)
Mattsson, Sören (1)
Johansson, S (1)
Engvall, Jan, 1953- (1)
Klareskog, Lars (1)
Wallin, Lars (1)
Rosenquist, Richard (1)
Almén, Edgar, 1943 (1)
Rutqvist, Lars Erik (1)
Rojas, Ramiro (1)
Öhlander, Björn (1)
Vene, Sirkka (1)
Rombo, Lars (1)
Padyukov, Leonid (1)
Söderberg, Ola (1)
Andersson, Martin, 1 ... (1)
Tobin, Gerard (1)
Roos, Göran (1)
Tomczak, Maciej T. (1)
Horbowy, Jan (1)
Voss, Rudi (1)
Amombo Noa, Francois ... (1)
Plaganyi, Eva (1)
Waldo, Staffan (1)
Laytragoon-Lewin, No ... (1)
Askling, Helena H. (1)
Land, Magnus (1)
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University
Uppsala University (17)
Chalmers University of Technology (16)
Linköping University (7)
Örebro University (4)
Royal Institute of Technology (3)
Luleå University of Technology (3)
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University of Gothenburg (2)
Karolinska Institutet (2)
Stockholm University (1)
University of Gävle (1)
Swedish University of Agricultural Sciences (1)
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Language
English (26)
Swedish (11)
Latin (8)
Research subject (UKÄ/SCB)
Engineering and Technology (17)
Natural sciences (12)
Medical and Health Sciences (6)
Social Sciences (4)
Humanities (3)
Agricultural Sciences (1)

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