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1.	Doi, M, et al. (author) Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells 2002 In: The Journal of biological chemistry. - 0021-9258. ; 277:15, s. 12741-12748 Journal article (peer-reviewed)
2.	Wallquist, W, et al. (author) Impeded interaction between Schwann cells and axons in the absence of laminin alpha4 2005 In: The Journal of neuroscience : the official journal of the Society for Neuroscience. - 1529-2401. ; 25:14, s. 3692-3700 Journal article (peer-reviewed)
3.	Patton, BL, et al. (author) Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4 2001 In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1097-6256 .- 1546-1726. ; 4:6, s. 597-604 Journal article (peer-reviewed)
4.	Thyboll, J, et al. (author) Deletion of the laminin alpha4 chain leads to impaired microvessel maturation 2002 In: Molecular and cellular biology. - 0270-7306. ; 22:4, s. 1194-1202 Journal article (peer-reviewed)
5.	Thyboll, J, et al. (author) Perinatal anemia in laminin alpha 4 knock out mice 1999 In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - 0022-202X. ; 113:6, s. 1139-1139 Conference paper (other academic/artistic)
6.	Wondimu, Z, et al. (author) An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis 2004 In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 104:6, s. 1859-1866 Journal article (peer-reviewed)abstract During extravasation, neutrophils migrate through the perivascular basement membrane (BM), a specialized extracellular matrix rich in laminins. Laminins 8 (LN-8) (α4β1γ1) and 10 (LN-10) (α5β1γ1) are major components of the endothelial BM, but expression, recognition, and use of these laminin isoforms by neutrophils are poorly understood. In the present study, we provide evidence, using a panel of novel monoclonal antibodies against human laminin α4 (LNα4) chain, that neutrophils contain and secrete LN-8, and that this endogenous laminin contributes to chemoattractant-induced, αMβ2-integrin–dependent neutrophil migration through albumin-coated filters. Phorbol ester–stimulated neutrophils adhered to recombinant human (rh) LN-8, rhLN-10, and mouse LN-1 (mLN-1) (α1β1γ1) via αMβ2-integrin, and these laminin isoforms strongly promoted chemoattractant-induced neutrophil migration via the same integrin. However, only rhLN-8 enhanced the spontaneous migration. In addition, recruitment of neutrophils into the peritoneum following an inflammatory stimulus was impaired in LNα4-deficient mice. rhLN-8 also protected isolated neutrophils from spontaneous apoptosis. This study is the first to identify a specific laminin isoform in neutrophils and provides evidence for the role of LN-8 in the adhesion, migration, extravasation, and survival of these cells.

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Result 1-6 of 6

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Type of publication: journal article (5); conference paper (1)

Type of content: peer-reviewed (5); other academic/artistic (1)

Author/Editor: Tryggvason, K (6); Thyboll, J (6); Kortesmaa, J (6); Iivanainen, A (3); Wang, L (2); Westerblad, H (2); show more...; Risling, M (2); Doi, M. (2); Soininen, R (2); Ogren, SO (1); Patarroyo, M (1); Swedenborg, J (1); Hedin, U (1); Lindbom, L (1); Jansson, K. (1); Edstrom, L (1); Plantman, S (1); Domogatskaya, A (1); Xie, X. (1); Juronen, E (1); Fadeel, B (1); Cao, YH (1); Lannergren, J (1); Cao, RH (1); Timpl, R (1); Cullheim, S (1); Thams, S. (1); Cunningham, JM (1); Ingerpuu, S (1); Wallquist, W (1); Hammarberg, H (1); Parvardeh, M (1); Sorokin, L (1); Sanes, JR (1); Geberhiwot, T (1); Wondimu, Z (1); Patton, BL (1); show less...

University: Karolinska Institutet (6)

Language: English (6)

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