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Träfflista för sökning "WFRF:(Thygesen Kristian S.) "

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  • Krychtiuk, Konstantin A., et al. (author)
  • Biomarkers of coagulation and fibrinolysis in acute myocardial infarction : a joint position paper of the Association for Acute Cardio Vascular Care and the European Society of Cardiology Working Group on Thrombosis
  • 2021
  • In: European Heart Journal. - : Oxford University Press. - 2048-8726 .- 2048-8734. ; 10:3, s. 343-355
  • Research review (peer-reviewed)abstract
    • The formation of a thrombus in an epicardial artery may result in an acute myocardial infarction (AMI). Despite major advances in acute treatment using network approaches to allocate patients to timely reperfusion and optimal antithrombotic treatment, patients remain at high risk for thrombotic complications. Ongoing activation of the coagulation system as well as thrombin-mediated platelet activation may both play a crucial role in this context. Whether measurement of circulating biomarkers of coagulation and fibrinolysis could be useful for risk stratification in secondary prevention is currently not fully understood. In addition, measurement of such biomarkers could be helpful to identify thrombus formation as the leading mechanism for AMI. The introduction of biomarkers of myocardial injury such as high-sensitivity cardiac troponins made rule-out of AMI even more precise. However, elevated markers of myocardial injury cannot provide proof of a type 1 AMI, let alone thrombus formation. The combined measurement of markers of myocardial injury with biomarkers reflecting ongoing thrombus formation might be helpful for the fast and correct diagnosis of an atherothrombotic type 1 AMI. This position paper gives an overview of the current knowledge and possible role of biomarkers of coagulation and fibrinolysis for the diagnosis of AMI, risk stratification, and individualized treatment strategies in patients with AMI.
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  • Thygesen, Kristian, et al. (author)
  • Recommendations for the use of cardiac troponin measurement in acute cardiac care
  • 2010
  • In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 31:18, s. 2197-2204
  • Journal article (peer-reviewed)abstract
    • The release of cardiomyocyte components, i.e. biomarkers, into the bloodstream in higher than usual quantities indicates an ongoing pathological process. Thus, detection of elevated concentrations of cardiac biomarkers in blood is a sign of cardiac injury which could be due to supply-demand imbalance, toxic effects, or haemodynamic stress. It is up to the clinician to determine the most probable aetiology, the proper therapeutic measures, and the subsequent risk implied by the process. For this reason, the measurement of biomarkers always must be applied in relation to the clinical context and never in isolation. There are a large number of cardiac biomarkers, but they can be subdivided into four broad categories, those related to necrosis, inflammation, haemodynamic stress, and/or thrombosis. Their usefulness is dependent on the accuracy and reproducibility of the measurements, the discriminatory limits separating pathology from physiology, and their sensitivity and specificity for specific organ damage and/or disease processes. In recent years, cardiac biomarkers have become important adjuncts to the delivery of acute cardiac care. Therefore, the Working Group on Acute Cardiac Care of the European Society of Cardiology established a committee to deal with ongoing and newly developing issues related to cardiac biomarkers. The intention of the group is to outline the principles for the application of various biomarkers by clinicians in the setting of acute cardiac care in a series of expert consensus documents. The first of these will focus on cardiac troponin, a pivotal marker of cardiac injury/necrosis.
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  • Result 1-10 of 29
Type of publication
journal article (25)
research review (4)
Type of content
peer-reviewed (26)
other academic/artistic (3)
Author/Editor
Thygesen, Kristian (25)
Jaffe, Allan S. (23)
Huber, Kurt (15)
Giannitsis, Evangelo ... (15)
Mair, Johannes (15)
Mueller, Christian (14)
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Lindahl, Bertil, 195 ... (11)
Plebani, Mario (10)
Alpert, Joseph S (10)
White, Harvey D. (7)
Lindahl, Bertil (6)
Chaitman, Bernard R (6)
Bax, Jeroen J (6)
Morrow, David A. (5)
Hamm, Christian W (5)
Simoons, Maarten L (5)
Mills, Nicholas L. (5)
Tubaro, Marco (5)
Hammarsten, Ola (4)
Tendera, Michal (4)
Katus, Hugo A (4)
Filippatos, Gerasimo ... (4)
Armstrong, Paul W. (4)
Wijns, William (4)
Morais, Joao (4)
Newby, L Kristin (4)
Bassand, Jean-Pierre (4)
Fox, Keith A (4)
Clemmensen, Peter M. (4)
Nieminen, Markku S. (4)
Parkhomenko, Alexand ... (4)
Antman, Elliott M (4)
Apple, Fred S (3)
Atar, Dan (3)
Steg, Ph Gabriel (3)
Pinto, Fausto (3)
Januzzi, James L. (3)
Venge, Per (3)
Ohman, E. Magnus (3)
Moeckel, Martin (3)
Katus, Hugo (3)
Koenig, Wolfgang (3)
Fortmann, Stephen P. (3)
Collinson, Paul (3)
Johanson, Per (3)
Smith, Sidney C (3)
Gibbons, Raymond J (3)
Weaver, Douglas (3)
Hamm, Christian (3)
Wallentin, Lars C., ... (3)
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University
Uppsala University (23)
University of Gothenburg (5)
Karolinska Institutet (2)
Linköping University (1)
Malmö University (1)
Chalmers University of Technology (1)
Language
English (29)
Research subject (UKÄ/SCB)
Medical and Health Sciences (19)
Natural sciences (2)
Engineering and Technology (1)

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