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Träfflista för sökning "WFRF:(Tjerneld Erica.) "

Search: WFRF:(Tjerneld Erica.)

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1.
  • Arvidsson, Per I., et al. (author)
  • Preparation of imidazolylpyrimidine derivatives for treatment of glycogen synthase kinase 3 related disorders such as Alzheimer's disease.
  • 2010
  • Patent (pop. science, debate, etc.)abstract
    • Title compds. I [R1 = H or F; R2 and R3 independently = H or Me], and their pharmaceutically acceptable salts, are prepd. and disclosed as agents for treatment of glycogen synthase kinase 3 (GSK3) related disorders such as Alzheimer's disease. Thus, e.g., II.HCl was prepd. by reductive amination of 4-bromo-3-fluorobenzaldehyde with (S)-3-methylmorpholine followed by amination with 2-amino-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidine. Select I were evaluated for GSK3β inhibitory activity, and e.g., II·HCl demonstrated a Ki value of 30 nM. [on SciFinder(R)]
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  • Result 1-1 of 1
Type of publication
patent (1)
Type of content
pop. science, debate, etc. (1)
Author/Editor
Arvidsson, Per I. (1)
Yngve, Ulrika. (1)
Burrows, Jeremy Nich ... (1)
Tjerneld, Erica. (1)
University
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2010 (1)

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