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Search: WFRF:(Trogen G B)

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  • Trogen, G B, et al. (author)
  • The solution NMR structure of a blue-green algae hepatotoxin, microcystin-RR--a comparison with the structure of microcystin-LR.
  • 1998
  • In: European Journal of Biochemistry. - 0014-2956 .- 1432-1033. ; 258:2, s. 301-12
  • Journal article (peer-reviewed)abstract
    • The microcystin-RR structures are compared with the structures of microcystin-LR in solution as well as in the crystal structure of the complex with protein phosphatase. The gross structures of the two peptides are similar, but with a more accentuated and compact saddle structure for microcystin-RR. The structural differences affect the hydrogen-bond pattern in the peptides and the location of the side chain of N-methyldehydroalanine, both of which are important for the ability of the peptide to form a tight complex with protein phosphatase. These structural differences may contribute to the observed differences in toxicity of microcystin-RR and microcystin-LR.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Larsson, Göran (1)
Sethson, I. (1)
Edlund, U (1)
Trogen, G B (1)
University
Umeå University (1)
Language
English (1)
Year
1998 (1)

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