| 1. |
- Phu, Vu Dinh, et al.
(author)
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Ventilator-associated respiratory infection in a resource-restricted setting: impact and etiology
- 2017
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In: Journal of Intensive Care. - : BioMed Central (BMC). - 2052-0492. ; 5
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Journal article (peer-reviewed)abstract
- Ventilator-associated respiratory infection (VARI) is a significant problem in resource-restricted intensive care units (ICUs), but differences in casemix and etiology means VARI in resource-restricted ICUs may be different from that found in resource-rich units. Data from these settings are vital to plan preventative interventions and assess their cost-effectiveness, but few are available.
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| 2. |
- Tran, Dien M., et al.
(author)
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High prevalence of colonisation with carbapenem-resistant Enterobacteriaceae among patients admitted to Vietnamese hospitals : Risk factors and burden of disease
- 2019
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In: Journal of Infection. - : Saunders Elsevier. - 0163-4453 .- 1532-2742. ; 79:2, s. 115-122
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Journal article (peer-reviewed)abstract
- BackgroundCarbapenem-resistant Enterobacteriaceae (CRE) is an increasing problem worldwide, but particularly problematic in low- and middle-income countries (LMIC) due to limitations of resources for surveillance of CRE and infection prevention and control (IPC).MethodsA point prevalence survey (PPS) with screening for colonisation with CRE was conducted on 2233 patients admitted to neonatal, paediatric and adult care at 12 Vietnamese hospitals located in northern, central and southern Vietnam during 2017 and 2018. CRE colonisation was determined by culturing of faecal specimens on selective agar for CRE. Risk factors for CRE colonisation were evaluated. A CRE admission and discharge screening sub-study was conducted among one of the most vulnerable patient groups; infants treated at an 80-bed Neonatal ICU from March throughout June 2017 to assess CRE acquisition, hospital-acquired infection (HAI) and treatment outcome.ResultsA total of 1165 (52%) patients were colonised with CRE, most commonly Klebsiella pneumoniae (n=805), Escherichia coli (n=682) and Enterobacter spp. (n=61). Duration of hospital stay, HAI and treatment with a carbapenem were independent risk factors for CRE colonisation. The PPS showed that the prevalence of CRE colonisation increased on average 4.2 % per day and mean CRE colonisation rates increased from 13% on the day of admission to 89% at day 15 of hospital stay. At the NICU CRE colonisation increased from 32% at admission to 87% at discharge, mortality was significantly associated (OR 5•5, P < 0•01) with CRE colonisation and HAI on admission.ConclusionThese data indicate that there is an epidemic spread of CRE in Vietnamese hospitals with rapid transmission to hospitalised patients.
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| 3. |
- Minh, Hoang Van, et al.
(author)
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Tobacco Control Policies in Vietnam : Review on MPOWER Implementation Progress and Challenges
- 2016
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In: Asian Pacific Journal of Cancer Prevention. - 1513-7368. ; 17, s. 1-9
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Journal article (peer-reviewed)abstract
- In Vietnam, the WHO Framework Convention on Tobacco Control (WHO FCTC) took effect in March 2005 while MPOWER has been implemented since 2008. This paper describes the progress and challenges of implementation of the MPOWER package in Vietnam. We can report that, in term of monitoring, Vietnam is very active in the Global Tobacco Surveillance System, completing two rounds of the Global Adult Tobacco Survey (GATS) and three rounds of the Global Youth Tobacco Survey (GYTS). To protect people from tobacco smoke, Vietnam has issued and enforced a law requiring comprehensive smoking bans at workplaces and public places since 2013. Tobacco advertising and promotion are also prohibited with the exception of points of sale displays of tobacco products. Violations come in the form of promotion girls, corporate social responsibility activities from tobacco manufacturers and packages displayed by retail vendors. Vietnam is one of the 77 countries that require pictorial health warnings to be printed on cigarette packages to warn about the danger of tobacco and the warnings have been implemented effectively. Cigarette tax is 70% of factory price which is equal to less than 45% of retail price and much lower than the recommendation of WHO. However, Vietnam is one of the very few countries that require manufacturers and importers to make "compulsory contributions" at 1-2% of the factory price of cigarettes sold in Vietnam for the establishment of a Tobacco Control Fund (TCF). The TCF is being operated well. In 2015, 67 units of 63 provinces/cities, 22 ministries and political-social organizations and 6 hospitals received funding from TCF to implement a wide range of tobacco control activities. Cessation services have been starting with a a toll-free quit-line but need to be further strengthened. In conclusion, Vietnam has constantly put efforts into the tobacco control field with high commitment from the government, scientists and activists. Though several remarkable achievements have been gained, many challenges remain. To overcome those challenges, implementation strategies that take into account the contextual factors and social determinants of tobacco use in Vietnam are needed.
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| 4. |
- Dao, Trong Tuan, et al.
(author)
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Resveratrol suppressed lps-induced cox-2 VIA miR-146a-5p inhibition in raw246.7 cells
- 2017
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In: Farmacia. - 0014-8237. ; 65:2, s. 214-218
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Journal article (peer-reviewed)abstract
- Trans-resveratrol (Res) is a well-known natural stilbene frequently found in grapes which have been reported to possess antioxidant, anti-cancer activities and inhibited COX-2 expression. MicroRNAs (miRNAs) are short endogenous non-coding RNAs involved in the regulation of mRNA stability and protein synthesis. In our research, resveratrol isolated from Vitis heyneana Roem. & Schult Vitis heyneana was observed to suppress lipopolysaccharides (LPS)-induced COX-2 expression in Raw264.7 cells in a dose dependent manner. Using qPCR it was revealed that LPS induced the expression of miR-25, miR- 125a, miR-125b, miR-146a-5p, miR-146a-3p and miR-455. However, we only observed miR-146a-5p expression significantly decreased in resveratrol compared to untreated-control group. In addition, resveratrol abrogated the effect of miR-146a-5p mimic induced-COX-2 expression in Raw264.7 cells. Taken together, this study demonstrated for the first time the involvement of miR-146a-5p in resveratrol inhibited LPS-induced COX-2 expression in Raw264.7 cells.
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| 5. |
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| 6. |
- Trung, Hieu Tran, et al.
(author)
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Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3-seco-Tirucallane Triterpenoids Meliadubins A and B from Melia dubia Cav. Barks with ChemGPS-NP and In Silico Prediction
- 2023
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In: ACS Omega. - : American Chemical Society (ACS). - 2470-1343. ; 8:40, s. 37116-37127
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Journal article (peer-reviewed)abstract
- Two new rearranged 2,3-seco-tirucallane triterpenoids, meliadubins A (1) and B (2), along with four known compounds, 3-6, were isolated from the barks of Melia dubia Cav. Compound 2 exhibited a significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC50 at 5.54 +/- 0.36 mu M). It bound to active sites of a human inducible nitric oxide synthase (3E7G) through interactions with the residues of GLU377 and PRO350, which may benefit in reducing the neutrophilic inflammation effect. The ChemGPS-NP interpretation combined with bioactivity assay and in silico prediction results suggested 2 to be an agent for targeting iNOS with different mechanisms as compared to a selected set of current approved drugs. Moreover, compounds 1 and 2 showed remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae in a dose-dependent manner with IC50 values of 137.20 +/- 9.55 and 182.50 +/- 18.27 mu M, respectively. Both 1 and 2 displayed interactions with the residue of TYR223, a key active site of trihydroxynaphthalene reductase (1YBV). The interpretation of 1 and 2 in the ChemGPS-NP physical-chemical property space indicated that both compounds are quite different compared to all members of a selected set of reference compounds. In light of demonstrated biological activity and in silico prediction experiments, both compounds possibly exhibited activity against phytopathogenic fungi via a novel mode of action.
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| 7. |
- Chung, Sunjae, et al.
(author)
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Magnetic droplet solitons in all-perpendicular nano-contact spin torque oscillators
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Other publication (pop. science, debate, etc.)abstract
- Spin-torque-generated magnetic droplets are nontopological solitons that have both dynamic and static characteristics. Although theoretical studies of these droplets originally dealt with an all-perpendicular magnetic system, all experimental demonstrations have so far relied on orthogonal spin valve structures that require a rather strong magnetic field to nucleate the droplet. Here, for the first time, we show the nucleation and sustained operation of magnetic droplets under a low magnetic field using nanocontact spin-torque oscillators (NC-STO), both the free Co/Ni and fixed Co/Pd multilayers of which have strong perpendicular magnetic anisotropy. Droplet nucleation is observed as a change in the NC-STO resistance and the appearance of significant broadband microwave signal generation below 1 GHz. We also observe another important phenomenon in which the nucleated magnetic droplet can transform into a skyrmionic nanobubble in the low-field regime. Both magnetic droplet solitons and skyrmionic nanobubbles have been studied in detail using micromagnetic simulation.
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| 8. |
- Dao, Tuan Anh, et al.
(author)
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A multi-criteria optimization model for emission-concerned multi-depot vehicle routing problem with heterogeneous fleet
- 2018
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In: 2018 International Conference on Applied Smart Systems (ICASS). - : Institute of Electrical and Electronics Engineers (IEEE). - 9781538668665 - 9781538668658 - 9781538668672
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Conference paper (peer-reviewed)abstract
- Not only greenhouse gases but also other air pollutant emissions from transportation have direct impacts on the environment and human health. The challenge of solving the conflict between profit and environmental consequences in logistics has motivated many studies on the vehicle routing problem. In this paper, a multiobjective mixed integer linear programming model is proposed to minimize transportation expenses and pollutant emissions for the multi-depot heterogeneous vehicle routing problem. A metaheuristic is adapted to obtain the Pareto optimal solutions. After a search procedure, decision makers are able to choose among best transportation plans that balance many objectives at once including economic benefits and environmental impacts. Computational experiments are performed on seven well-known benchmark problem sets. The results demonstrate the existence of greener transportation plans, which are illustrated alongside the best solutions previously reported. The study shows that, in return for a minimal economic tradeoff, a substantial amount of pollution could be avoided.
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| 9. |
- Duong, Ngoc Son, et al.
(author)
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Sparse Bayesian Learning with Atom Refinement for mmWave MIMO Channel Estimation
- 2023
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In: IEEE Workshop on Statistical Signal Processing Proceedings. ; 2023-July, s. 155-159
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Conference paper (peer-reviewed)abstract
- In this paper, we introduce a novel estimation method for the downlink millimeter-wave (mmWave) multiple-input multiple-output (MIMO) channel. The proposed method is able to determine the angles, time delays, and gains of the multi-path components by using the spatially sparse nature of mmWave channels. We first use on-grid sparse Bayesian learning (SBL) to coarsely estimate the channel parameters in the beamspace domain. We then develop a refinement method based on Newton-Raphson and Least Square-based atomic tuning to generate a mismatch-free basis. Finally, we finely reconstruct the channel by SBL using the basis found in the previous step. Simulation results show that the proposed channel estimation method outperforms the traditional ones in terms of mean square error and algorithmic complexity.
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| 10. |
- Le, Quang Tuan, 1976-, et al.
(author)
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Bias dependence of parallel spin torque in all-perpendicular magnetic tunnel junction nanodevices
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Other publication (pop. science, debate, etc.)abstract
- We performed spin-torque ferromagnetic resonance measurements on spin-torque oscillators based on CoFeB/MgO/CoFeB magnetic tunnel junctions (MTJs), with both free and fixed layers having perpendicular magnetic anisotropy, under the application of an in-plane field. A dc current between near-zero and -250 $\mu{A}$ was introduced to investigate the influence of spin-transfer torque effects on the asymmetric and symmetric components of the output voltage. Both components showed a minimum at a misalignment of about 30$^\circ$ between the magnetization of the two CoFeB layers, indicating a strong electric-field effect. We also found that the bias dependence of the spin-torque terms is in contrast to that of in-plane anisotropy CoFeB MTJs.
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