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1.	Thorek, Daniel L J, et al. (author) Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis 2016 In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 8:367 Journal article (peer-reviewed)abstract Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. AR-regulated human kallikrein-related peptidase 2 (free hK2) is a prostate tissue-specific antigen produced in prostate cancer and androgen-stimulated breast cancer cells. Fluorescent and radio conjugates of 11B6, an antibody targeting free hK2, are internalized and noninvasively report AR pathway activity in metastatic and genetically engineered models of cancer development and treatment. Uptake is mediated by a mechanism involving the neonatal Fc receptor. Humanized 11B6, which has undergone toxicological tests in nonhuman primates, has the potential to improve patient management in these cancers. Furthermore, cellspecific SATA uptake may have a broader use for molecularly guided diagnosis and therapy in other cancers.

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Lilja, Hans (1); Abou, Diane S. (1); Ulmert, David (1); Thorek, Daniel L.J. (1); Strand, Sven-Erik (1); Larson, Steven M. (1); show more...; Scher, Howard I. (1); Veach, Darren (1); Scardino, Peter T. (1); Lewis, Jason S. (1); Braun, Katharina (1); Doran, Michael G. (1); Watson, Philip A. (1); Lee, Sang Gyu (1); Ku, Anson T. (1); Bournazos, Stylianos (1); Kim, Kwanghee (1); Sjostrom, Kjell (1); Lamminmaki, Urpo (1); Santos, Elmer (1); Turkekul, Mesruh (1); Casey, Emily (1); Van Voss, Marise R H (1); Alpaugh, Mary L. (1); show less...

University: Lund University (1)

Language: English (1)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

Year: 2016 (1)

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