↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Tuveson DA) "

Search: WFRF:(Tuveson DA)

Result 1-2 of 2

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Chio, Iok In Christine, et al. (author) NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer 2016 In: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 166:4, s. 936-976 Journal article (peer-reviewed)abstract Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate pancreatic and lung cancer initiation. Here, we show that NRF2 is necessary to maintain pancreatic cancer proliferation by regulating mRNA translation. Specifically, loss of NRF2 led to defects in autocrine epidermal growth factor receptor (EGFR) signaling and oxidation of specific translational regulatory proteins, resulting in impaired cap-dependent and cap-independent mRNA translation in pancreatic cancer cells. Combined targeting of the EGFR effector AKT and the glutathione antioxidant pathway mimicked Nrf2 ablation to potently inhibit pancreatic cancer ex vivo and in vivo, representing a promising synthetic lethal strategy for treating the disease.
2.	Laise, P, et al. (author) Pancreatic cancer comprises co-existing transcriptional states regulated by distinct master regulator programs. 2022 In: CANCER RESEARCH. - 0008-5472. ; 82:22, s. 5-5 Conference paper (other academic/artistic)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-2 of 2

Refine your search

Type of publication: conference paper (1); journal article (1)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Wilson, John (1); Wong, W (1); Wong, K (1); Lee, Eun Jung (1); Tan, X (1); Tomassoni, L (1); show more...; Iuga, AC (1); Turunen, M (1); Chio, Iok In Christi ... (1); Ponz-Sarvise, Marian ... (1); Tiriac, Hervé (1); Wright, Kevin (1); Park, Youngkyu (1); Hao, Yuan (1); Pappin, Darryl J (1); Hammell, Molly (1); Tuveson, David A (1); Notta, F (1); Rivera, Keith (1); Jafarnejad, Seyed Me ... (1); Palm, Wilhelm (1); Sangar, Vineet (1); Öhlund, Daniel (1); Filippini, Dea (1); Da Silva, Brandon (1); Schoepfer, Christina (1); Wilkinson, John Erby (1); Buscaglia, Jonathan ... (1); DeNicola, Gina M (1); Crawford, Howard C (1); Schmidt, Edward E (1); Thompson, Craig B (1); Sonenberg, Nahum (1); Califano, A (1); Garcia, AC (1); Schmierer, B (1); Laise, P (1); Maurer, HC (1); Elyada, E (1); Worley, J (1); Alvarez, MJ (1); Kesner, J (1); Tagore, S (1); Fernandez, EC (1); Wang, ALE (1); Ge, S (1); Griffin, AT (1); Manji, GA (1); Tuveson, DA (1); Olive, KPP (1); show less...

University: Umeå University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view