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- Canesin, Giacomo, et al.
(author)
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Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases
- 2020
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 32:12
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Journal article (peer-reviewed)abstract
- Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.
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