| 1. |
- Kronvall, Erik, et al.
(author)
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Nimodipine in aneurysmal subarachnoid hemorrhage: a randomized study of intravenous or peroral administration.
- 2009
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In: Journal of Neurosurgery. - 0022-3085. ; 110, s. 58-63
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Journal article (peer-reviewed)abstract
- Object The calcium antagonist nimodipine has been shown to reduce the incidence of ischemic complications following aneurysmal subarachnoid hemorrhage (SAH). Although most randomized studies have been focused on the effect of the peroral administration of nimodipine, intravenous infusion is an alternative and the preferred mode of treatment in many centers. It is unknown whether the route of administration is of any importance for the clinical efficacy of the drug. Methods One hundred six patients with acute aneurysmal SAH were randomized to receive either peroral or intravenous nimodipine treatment. The patients were monitored for at least 10 days after bleeding in terms of delayed ischemic neurological deficits (DINDs) and with daily measurements of blood flow velocities in the middle cerebral arteries by using transcranial Doppler ultrasonography. Three months after SAH, clinical outcome and new cerebral infarctions according to MR imaging studies were recorded. Results Baseline characteristics (age, sex distribution, clinical status on admission, radiological findings, and aneurysm treatment) did not differ between the treatment groups. There was no significant difference in the incidence of DINDs (28 vs 30% in the peroral and intravenous groups, respectively) or middle cerebral artery blood flow velocities (> 120 cm/second, 50 vs 45%, respectively). Clinical outcome according to the Glasgow Outcome Scale was the same in both groups, and there was no difference in the number of patients with new infarctions on MR imaging. Conclusions The results suggest that there is no clinically relevant difference in efficacy between peroral and intravenous administration of nimodipine in preventing DINDs or cerebral vasospasm following SAH.
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| 2. |
- Löve, Askell, et al.
(author)
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Hybrid Iterative Reconstruction Algorithm Improves Image Quality in Craniocervical CT Angiography.
- 2013
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In: American Journal of Roentgenology: diagnostic imaging and related sciences. - 1546-3141. ; 201:6, s. 861-866
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Journal article (peer-reviewed)abstract
- OBJECTIVE. The purpose of this study was to evaluate the potential of a hybrid iterative reconstruction algorithm for improving image quality in craniocervical CT angiography (CTA) and to assess observer performance. SUBJECTS AND METHODS. Thirty patients (mean age, 58 years; range 16-80 years) underwent standard craniocervical CTA (volume CT dose index, 6.8 mGy, 2.8 mSv). Images were reconstructed using both filtered back projection (FBP) and a hybrid iterative reconstruction algorithm. Five neuroradiologists assessed general image quality and delineation of the vessel lumen in seven arterial segments using a 4-grade scale. Interobserver and intraobserver variability were determined. Mean attenuation and noise were measured and signal-to-noise and contrast-to-noise ratios calculated. Descriptive statistics are presented and data analyzed using linear mixed-effects models. RESULTS. In pooled data, image quality in iterative reconstruction was graded superior to FBP regarding all five quality criteria (p < 0.0001), with the greatest improvement observed in the vertebral arteries. Iterative reconstruction resulted in elimination of arterial segments graded poor. Interobserver percentage agreement was significantly better (p = 0.024) for iterative reconstruction (69%) than for FBP (66%) but worse than intraobserver percentage agreement (mean, 79%). Noise levels, signal-to-noise ratio, and contrast-to-noise ratio were significantly (p < 0.001) improved in iterative reconstruction at all measured levels. CONCLUSION. The iterative reconstruction algorithm significantly improves image quality in craniocervical CT, especially at the thoracic inlet. Despite careful study design, considerable interobserver and intraobserver variability was noted.
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| 3. |
- Mellander, Helena, et al.
(author)
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Virtual monoenergetic images by spectral detector computed tomography may improve image quality and diagnostic ability for ischemic lesions in acute ischemic stroke
- 2023
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In: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 64:4, s. 1631-1640
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Journal article (peer-reviewed)abstract
- Background: Acute ischemic lesions are challenging to detect by conventional computed tomography (CT). Virtual monoenergetic images may improve detection rates by increased tissue contrast. Purpose: To compare the ability to detect ischemic lesions of virtual monoenergetic with conventional images in patients with acute stroke. Material and Methods: We included consecutive patients at our center that underwent brain CT in a spectral scanner for suspicion of acute stroke, onset <12 h, with or without (negative controls) a confirmed cortical ischemic lesion in the initial scan or a follow-up CT or magnetic resonance imaging. Attenuation was measured in predefined areas in ischemic gray (guided by follow-up exams), normal gray, and white matter in conventional images and retrieved in spectral diagrams for the same locations in monoenergetic series at 40–200 keV. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. Visual assessment of diagnostic measures was performed by independent review by two neuroradiologists blinded to reconstruction details. Results: In total, 29 patients were included (January 2018 to July 2019). SNR was higher in virtual monoenergetic compared to conventional images, significantly at 60–150 keV. CNR between ischemic gray and normal white matter was higher in monoenergetic images at 40–70 keV compared to conventional images. Virtual monoenergetic images received higher scores in overall image quality. The sensitivity for diagnosing acute ischemia was 93% and 97%, respectively, for the reviewers, compared to 55% of the original report based on conventional images. Conclusion: Virtual monoenergetic reconstructions of spectral CIs may improve image quality and diagnostic ability in stroke assessment.
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| 4. |
- Morén, Håkan, et al.
(author)
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Angiography and mfERG show that blood supply to the pig retina may be both ipsilateral and contralateral.
- 2013
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In: Investigative Ophthalmology & Visual Science. - : Association for Research in Vision and Ophthalmology (ARVO). - 1552-5783. ; 54:9, s. 6112-6117
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Journal article (peer-reviewed)abstract
- Purpose: We recently presented a transfemoral endovascular coiling technique for inducing experimental retinal ischemia in pigs. Substantial variation was seen in the degree of ischemia. It was hypothesized that the blood supply to the retina may originate from both the ipsi- and contralateral ophthalmic arteries, and that there may be an interconnecting artery between the eyes. Methods: The external carotid system of ten pigs was catheterized using a fluoroscopy- monitored, transfemoral, endovascular approach. Vascular occlusion was achieved in the ophthalmic artery using coils. The effect of occlusion was examined using angiography and multifocal electroretinography (mfERG). Results: During angiography of the ophthalmic artery on one side, contrast filling was seen in the retinas on both sides, suggesting that the ophthalmic artery on one side may supply both retinas. A blood vessel connecting the eyes was visualized. mfERG recordings showed that the use of coiling to occlude the ophthalmic artery had greater ischemic effects in eyes that depended mainly on the ipsilateral ophthalmic artery for blood supply and smaller ischemic effect in retinas that received blood from both the ipsilateral and contralateral ophthalmic artery via the interconnecting vessel. Conclusions: The blood supply to the retina may originate from both the ipsi- and contralateral ophthalmic artery in the pig. There is an interindividual variability in the ischemic effect of occlusion depending on the architecture of the vasculature. These findings may be important in the development of new animal models of experimental retinal ischemia, since arterial occlusion in one eye may affect the blood supply to the contralateral eye.
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| 5. |
- Morén, Håkan, et al.
(author)
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Endovascular Coiling of the Ophthalmic Artery in Pigs to Induce Retinal Ischemia
- 2011
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In: Investigative Ophthalmology & Visual Science. - : Association for Research in Vision and Ophthalmology (ARVO). - 1552-5783. ; 52:7, s. 4880-4885
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Journal article (peer-reviewed)abstract
- PURPOSE. The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in the vasculature to cause retinal ischemia with different degrees of severity was investigated. METHODS. The ophthalmic artery was catheterized through the external carotid system using a fluoroscopy-monitored, transfemoral, endovascular approach in 12 pigs (mean weight, 70 kg). The effects were evaluated using angiography and multifocal electroretinography. RESULTS. Occlusion of arteries supplying the retina was established using endovascular coiling. Coiling in the proximal part of the ophthalmic artery caused no or little ischemia, presumably because of collateral blood supply. Coiling in the distal part of the ophthalmic artery, over the branching of the main ciliary artery, caused more severe retinal ischemia. Multifocal electroretinography recordings, which reflect retinal function in an area close to the visual streak, showed decreased amplitudes and increased implicit times after distal occlusion, but not after proximal occlusion of the ophthalmic artery. The responses were similar 1 hour and 72 hours after coiling, indicating that a permanent ischemic injury was established. CONCLUSIONS. The porcine ophthalmic artery can be occluded using an endovascular coiling technique. This provides an experimental animal model of retinal ischemia in which occlusion at different sites of the vasculature produces different degrees of severity of the ischemic damage. (Invest Ophthalmol Vis Sci. 2011;52:4880-4885) DOI:10.1167/iovs.11-7628
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| 6. |
- Morén, Håkan, et al.
(author)
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The porcine retinal vasculature can be accessed using an endovascular approach, a new experimental model for retinal ischemia.
- 2009
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In: Investigative Ophthalmology & Visual Science. - : Association for Research in Vision and Ophthalmology (ARVO). - 1552-5783. ; 50:11, s. 5504-5510
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Journal article (peer-reviewed)abstract
- Purpose. The aim was to examine if the retinal circulation in the pig can be accessed using interventional neuroradiology and to explore the possibility to create occlusions that result in experimental retinal ischemia. Methods. Six experiments were performed using 100 kg pigs. The external carotid system was catheterizised using fluoroscopy monitored, transfemoral, endovascular approach. Transient and permanent vascular occlusions were performed using an angioplasty balloon catheter or a liquid embolic agent that was administered via an injection-catheter. Results. A technique for transfemoral catheterization of arteries supplying the retina was established. The ophthalmic artery was demonstrated to give rise to the main ciliary artery, from which the retinal artery branched as a single or several arteries. A balloon-catheter could be introduced into the ophthalmic artery, but not into the main ciliary artery. An injection-catheter could, in all experiments, be introduced into the main ciliary artery and, in some experiments, into the retinal artery. Occlusion of the ophthalmic artery, over the branching of the main ciliary artery, caused incomplete ischemia, presumably due to collaterals feeding the distal parts of the vasculature. mfERG recordings showed decreased amplitudes and increased implicit times, indicating retinal ischemia. Occlusion of the ciliary and retinal arteries caused complete ischemia, as shown by complete flattening of the mfERG recordings and, by indirect ophthalmoscopy, blanching of the retinal arteries and a pale retina Conclusions. We prove for the first time that the ophthalmic and retinal artery can be catheterizised using a transfemoral endovascular approach. This technique may be useful to produce clear-cut experimental retinal ischemia.
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| 7. |
- Mounayer, C, et al.
(author)
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Neck-bridge device for combined endovascular and surgical treatment of a giant anterior communicating artery aneurysm
- 2005
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In: Neuroradiology. - : Springer Science and Business Media LLC. - 1432-1920 .- 0028-3940. ; 47:4, s. 295-299
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Journal article (peer-reviewed)abstract
- We report the case of a 58-year-old man with a giant partially thrombosed anterior communicating artery aneurysm, which presented with mass effect. Our treatment strategy consisted of endovascular aneurysm circulatory exclusion prior to surgical resection. To do so, we first occluded both the two A1 segments and the aneurysm neck with a neck-bridge device to prevent further coil migration within the aneurysm sac. Five days later, the aneurysm was surgically removed.
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| 8. |
- Ramgren, Birgitta, et al.
(author)
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Endovascular treatment of vein of Galen aneurysmal malformation using rapid ventricular pacing : A case report
- 2017
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In: Interventional Neuroradiology. - : SAGE Publications. - 1591-0199 .- 2385-2011. ; 23:1, s. 97-101
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Journal article (peer-reviewed)abstract
- The treatment of choice of vein of Galen aneurysmal malformation (VGAM) involves endovascular procedures that can be difficult to perform in high-flow fistulas. We describe the use of rapid ventricular pacing (RVP), a well-known cardiologic technique, to safely treat a high-flow fistula in an infant with VGAM.
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| 9. |
- Ramgren, Birgitta, et al.
(author)
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Follow-up of intracranial aneurysms treated with detachable coils: comparison of 3D inflow MRA at 3T and 1.5T and contrast-enhanced MRA at 3T with DSA.
- 2008
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In: Neuroradiology. - : Springer Science and Business Media LLC. - 1432-1920 .- 0028-3940. ; 50, s. 947-954
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Journal article (peer-reviewed)abstract
- INTRODUCTION: The purpose of this prospective study was to compare 3T and 1.5T magnetic resonance angiography (MRA) with digital subtraction angiography (DSA) for the follow-up of endovascular treated intracranial aneurysms to assess the grade of occlusion. MATERIALS AND METHODS: Thirty-seven patients with 41 aneurysms who had undergone endovascular treatment with detachable coils were included. MRA was performed on the same day using an eight-channel sensitivity encoding head-coil with 3D axial inflow technique. At 3T, a contrast-enhanced transverse 3D fast gradient echo acquisition was also performed. Most patients underwent DSA the following day. MRA scans and DSA were classified first independently by two neuroradiologists and an interventional neuroradiologist. Secondly, a consensus was done. Source images, maximum intensity projection, multiplanar reconstruction and volume rendering reconstructions were used for MRA evaluations. A modification of the Raymond classification, previously used for DSA evaluation of recanalization, was used. RESULTS: Statistical comparison of the consensus showed that 3T MRA with 3D axial inflow technique had better agreement with DSA (kappa = 0.43) than 1.5T MRA(kappa = 0.21) and contrast-enhanced MRA (CE-MRA) at 3T (kappa = 0.17). The susceptibility artefacts from the coil mesh were significally smaller at 3T (p = 0.002-0.007) than at 1.5T. CONCLUSION: 3T MRA, using a sensitivity encoding head-coil, showed better agreement with DSA than 1.5T and CE-MRA at 3T for evaluation of aneurysms treated with endovascular coiling.
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