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- Pinches, S. D., et al.
(author)
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Implementation of plasma simulators and plasma reconstruction workflows in ITER’s Integrated Modelling & Analysis Suite (IMAS)
- 2017
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In: 44th EPS Conference on Plasma Physics, EPS 2017. - : European Physical Society (EPS).
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Conference paper (peer-reviewed)abstract
- IMAS has been installed within the majority of the ITER Members and is being used to support ITPA activities including code benchmarking and validation. Sophisticated workflows, such as Plasma Simulators and those describing H&CD systems, have been adapted to IMAS and applied to ITER scenarios. The framework is considered sufficiently flexible to handle all foreseen approaches to the integrated (probabilistic) determination of measurement parameters (and their errors). The inclusion of UDA within the IMAS data Access Layer has allowed the fetching of IDSs directly from experimental databases and the demonstration of the first plasma reconstruction chain. An interactive Live Display in which signals are selected through a web interface has also been demonstrated.
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| 3. |
- Bowman, E. M. L., et al.
(author)
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Advancing specificity in delirium: The delirium subtyping initiative
- 2024
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In: Alzheimers & Dementia. - 1552-5260. ; 20:1, s. 183-194
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Journal article (peer-reviewed)abstract
- BACKGROUNDDelirium, a common syndrome with heterogeneous etiologies and clinical presentations, is associated with poor long-term outcomes. Recording and analyzing all delirium equally could be hindering the field's understanding of pathophysiology and identification of targeted treatments. Current delirium subtyping methods reflect clinically evident features but likely do not account for underlying biology. METHODSThe Delirium Subtyping Initiative (DSI) held three sessions with an international panel of 25 experts. RESULTSMeeting participants suggest further characterization of delirium features to complement the existing Diagnostic and Statistical Manual of Mental Disorders Fifth Edition Text Revision diagnostic criteria. These should span the range of delirium-spectrum syndromes and be measured consistently across studies. Clinical features should be recorded in conjunction with biospecimen collection, where feasible, in a standardized way, to determine temporal associations of biology coincident with clinical fluctuations. DISCUSSIONThe DSI made recommendations spanning the breadth of delirium research including clinical features, study planning, data collection, and data analysis for characterization of candidate delirium subtypes. HighlightsDelirium features must be clearly defined, standardized, and operationalized.Large datasets incorporating both clinical and biomarker variables should be analyzed together.Delirium screening should incorporate communication and reasoning.
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| 4. |
- Mamode, N., et al.
(author)
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Donor Autonomy and Self-Sacrifice in Living Organ Donation: An Ethical Legal and Psychological Aspects of Transplantation (ELPAT) View
- 2022
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In: Transplant International. - : Frontiers Media SA. - 0934-0874 .- 1432-2277. ; 35:1
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Journal article (peer-reviewed)abstract
- Clinical teams understandably wish to minimise risks to living kidney donors undergoing surgery, but are often faced with uncertainty about the extent of risk, or donors who wish to proceed despite those risks. Here we explore how these difficult decisions may be approached and consider the conflicts between autonomy and paternalism, the place of self-sacrifice and consideration of risks and benefits. Donor autonomy should be considered as in the context of the depth and strength of feeling, understanding risk and competing influences. Discussion of risks could be improved by using absolute risk, supra-regional MDMs and including the risks to the clinical team as well as the donor. The psychological effects on the donor of poor outcomes for the untransplanted recipient should also be taken into account. There is a lack of detailed data on the risks to the donor who has significant co-morbidities.
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| 5. |
- Van Dellen, D., et al.
(author)
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Pre-emptive live donor kidney transplantation-moving barriers to opportunities: An ethical, legal and psychological aspects of organ transplantation view
- 2021
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In: World Journal of Transplantation. - 2220-3230. ; 11:4, s. 88-98
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Journal article (peer-reviewed)abstract
- Live donor kidney transplantation (LDKT) is the optimal treatment modality for end stage renal disease (ESRD), enhancing patient and graft survival. Pre-emptive LDKT, prior to requirement for renal replacement therapy (RRT), provides further advantages, due to uraemia and dialysis avoidance. There are a number of potential barriers and opportunities to promoting pre-emptive LDKT. Significant infrastructure is needed to deliver robust programmes, which varies based on socio-economic standards. National frameworks can impact on national prioritisation of pre-emptive LDKT and supporting education programmes. Focus on other programme's components, including deceased kidney transplantation and RRT, can also hamper uptake. LDKT programmes are designed to provide maximal benefit to the recipient, which is specifically true for pre-emptive transplantation. Health care providers need to be educated to maximize early LDKT referral. Equitable access for varying population groups, without socioeconomic bias, also requires prioritisation. Cultural barriers, including religious influence, also need consideration in developing successful outcomes. In addition, the benefit of pre-emptive LDKT needs to be emphasised, and opportunities provided to potential donors, to ensure timely and safe work-up processes. Recipient education and preparation for pre-emptive LDKT needs to ensure increased uptake. Awareness of the benefits of pre-emptive transplantation require prioritisation for this population group. We recommend an approach where patients approaching ESRD are referred early to pre-transplant clinics facilitating early discussion regarding pre-emptive LDKT and potential donors for LDKT are prioritized for work-up to ensure success. Education regarding preemptive LDKT should be the norm for patients approaching ESRD, appropriate for the patient's cultural needs and physical status. Pre-emptive transplantation maximize benefit to potential recipients, with the potential to occur within successful service delivery. To fully embrace preemptive transplantation as the norm, investment in infrastructure, increased awareness, and donor and recipient support is required. 2021 © adno.no.All right reserved.
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