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  • Bomhof, M, et al. (author)
  • Comparison of rizatriptan 10 mg vs. naratriptan 2.5 mg in migraine
  • 1999
  • In: European neurology. - : S. Karger AG. - 0014-3022 .- 1421-9913. ; 42:3, s. 173-179
  • Journal article (peer-reviewed)abstract
    • Rizatriptan (MAXALT<sup>TM</sup>, Merck & Co., Inc.) is a selective 5-HT<sub>1B/1D</sub> receptor agonist with rapid oral absorption and early onset of action for the acute treatment of migraine. This randomized, double-masked, double-dummy, placebo-controlled study compared rizatriptan 10 mg to naratriptan (NARAMIG<sup>TM</sup>, AMERGE<sup>TM</sup>, both Glaxo Wellcome plc) 2.5 mg in 522 patients treating a single migraine attack. Rizatriptan was more effective than naratriptan. Rizatriptan provided earlier headache relief than naratriptan (hazard ratio 1.62, p < 0.001), acting as early as 30 min. More patients were pain free at 2 h on rizatriptan than on naratriptan (44.8 vs. 20.7%, p < 0.001). Rizatriptan also provided earlier relief of associated migraine symptoms within 2 h than naratriptan and more patients had normal function at 2 h (39.3 vs. 22.6%, p < 0.001). Both active treatments were effective compared to placebo. Both active treatments were well tolerated. The most common side effects with rizatriptan were dizziness, asthenia/fatigue, nausea and somnolence, while the most common side effects with naratriptan were dizziness and asthenia/fatigue.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Patel, K (1)
Allen, C (1)
Bomhof, M (1)
Paz, J (1)
Legg, N (1)
Vandormael, K (1)
University
Karolinska Institutet (1)
Language
English (1)
Year

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