| 1. |
- Bollen, Katrien, et al.
(författare)
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McSweeney's and the Challenges of the Marketplace for Independent Publishing
- 2013
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Ingår i: CLCWeb. - : Purdue University (bepress). - 1481-4374. ; 15:4
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Tidskriftsartikel (refereegranskat)abstract
- In their article McSweeney's and the Challenges of the Marketplace for Independent Publishing Katrien Bollen, Stef Craps, and Pieter Vermeulen argue that the artistic projects of the US-American author, activist, and editor Dave Eggers are marked by a tension between the desire for independence and the demands of brand-building. The article offers a close analysis of the materiality and paratexts of one particular issue of McSweeney's, the literary magazine of which Eggers is the founding editor. Both the content and the apologetically aggressive tone of Eggers's editorial statements betray a deep unease with the inability to inhabit a cultural and economic position that is untainted by the compromises that publishing requires. Still, this disavowed complicity with the market in fact sustains Eggers's editorial practice in McSweeney's, which, in marked contrast to his explicit statements, thrives on a dynamic of commodification.
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| 2. |
- Bouazza, Naim, et al.
(författare)
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General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children
- 2022
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Ingår i: British Journal of Clinical Pharmacology. - : John Wiley & Sons. - 0306-5251 .- 1365-2125. ; 88:12, s. 4985-4996
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Forskningsöversikt (refereegranskat)abstract
- Pharmacometric modelling plays a key role in both the design and analysis of regulatory trials in paediatric drug development. Studies in adults provide a rich source of data to inform the paediatric investigation plans, including knowledge on drug pharmacokinetics (PK), safety and efficacy. In children, drug disposition differs widely from birth to adolescence but extrapolating adult to paediatric PK, safety and efficacy either with pharmacometric or physiologically based approaches can help design or in some cases reduce the need for clinical studies. Aspects to consider when extrapolating PK include the maturation of drug metabolizing enzyme expression, glomerular filtration, drug excretory systems, and the expression and activity of specific transporters in conjunction with other drug properties such as fraction unbound. Knowledge of these can be used to develop extrapolation tools such as allometric scaling plus maturation functions or physiologically based PK. PK/pharmacodynamic approaches and well-designed clinical trials in children are of key importance in paediatric drug development. In this white paper, state-of-the-art of current methods used for paediatric extrapolation will be discussed. This paper is part of a conect4children implementation of innovative methodologies including pharmacometric and physiologically based PK modelling in clinical trial design/paediatric drug development through dissemination of expertise and expert advice. The suggestions arising from this white paper should define a minimum set of standards in paediatric modelling and contribute to the regulatory science.
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| 3. |
- Carley, Eoin P., et al.
(författare)
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Radio observatories and instrumentation used in space weather science and operations
- 2020
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Ingår i: Journal of Space Weather and Space Climate. - : EDP Sciences. - 2115-7251. ; 10:Topical Issue - Scientific Advances from the European Commission H2020 projects on Space Weather
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Tidskriftsartikel (refereegranskat)abstract
- The low frequency array (LOFAR) is a phased array interferometer currently consisting of 13 international stations across Europe and 38 stations surrounding a central hub in the Netherlands. The instrument operates in the frequency range of similar to 10-240 MHz and is used for a variety of astrophysical science cases. While it is not heliophysics or space weather dedicated, a new project entitled "LOFAR for Space Weather" (LOFAR4SW) aims at designing a system upgrade to allow the entire array to observe the Sun, heliosphere, Earth's ionosphere, and Jupiter throughout its observing window. This will allow the instrument to operate as a space weather observing platform, facilitating both space weather science and operations. Part of this design study aims to survey the existing space weather infrastructure operating at radio frequencies and show how LOFAR4SW can advance the current state-of-the-art in this field. In this paper, we survey radio instrumentation and facilities that currently operate in space weather science and/or operations, including instruments involved in solar, heliospheric, and ionospheric studies. We furthermore include an overview of the major space weather service providers in operation today and the current state-of-the-art in the radio data they use and provide routinely. The aim is to compare LOFAR4SW to the existing radio research infrastructure in space weather and show how it may advance both space weather science and operations in the radio domain in the near future.
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| 4. |
- De Graef, Ortwin, et al.
(författare)
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Virgilian Incarnation : Hartman and the Issue of Auerbach’s Jewishness
- 2013
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Ingår i: Jewish Quarterly Review. - : Project Muse. - 0021-6682 .- 1553-0604. ; 103:2, s. 141-148
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Tidskriftsartikel (refereegranskat)abstract
- In his memoir A Scholar’s Tale, Geoffrey Hartman recognizes the decisive influence of Erich Auerbach, one of his teachers at Yale, on his own early work. Auerbach came to Yale after having spent the Second World War in Istanbul, where he wrote his magisterial Mimesis. That book not only bears the stamp of the war that was then ravaging Europe, the continent whose literary heritage he aimed to preserve in Mimesis, but also of a second trauma: the demise, somewhere (according to Auerbach) in between Dante and Montaigne, of a divinely sanctioned reality, which condemned the West to the historical world. For Auerbach, what saved this historical reality was the unfulfilled figure of the Incarnation still haunting it against all odds... The influence of Auerbach’s sense of lateness, and of the autumnal literary ethos it sustains, can be traced in Hartman’s lifelong engagement with William Wordsworth, whose exemplary remediation of the loss of rural life, Hartman recognizes, today threatens to fade away in our increasingly networked memory-and mediascapes. It is significant that in the last three decades, Hartman has supplemented his Romanticism and his work on the memory of the Holocaust with an increasingly explicit elaboration of the Jewish imagination. Does this point to the perceived insufficiency of Auerbach’s autumnal stance? Or does the tension between the literary, the disaster, and the religious point to an ethos beyond Incarnation?
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| 5. |
- Elmgren, Charlotta, 1972-
(författare)
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J.M. Coetzee's Poetics of the Child
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation explores how central tensions in J.M. Coetzee’s fiction converge in and are made visible by the child figure. Its central claim is that the child draws attention to how Coetzee’s poetics is characterized by a constant interplay between responsibility to the other—within and beyond history—on the one hand, and irresponsibility, indeterminacy and play on the other. Key to this argument is Giorgio Agamben’s emancipatory thinking on infancy, or the experience of the impotentiality of language, which can be understood as the capacity to hold thought in suspense. This complements productively those strands of existing Coetzee scholarship that, drawing on Blanchot, Levinas, and Derrida, find in Coetzee’s writing—and in responses to that writing—an ethics of hospitality to an alterity that is always yet to emerge. After an overview of interrelated conceptions and evocations of the child figure in theology, philosophy and literature, the study is organized around five central dynamics of a “poetics of the child” in Coetzee: The first chapter presents the child’s navigation between fictions of the self and of the world in a quest for authenticity as a compelling figure for Coetzee’s writing of fiction in the search for a never available truth of self. The second chapter argues that fictional encounters with “other” child figures within history are ethical in their destabilization of boundaries between self and other and in their foregrounding of ironic remainders made visible through different constructions of the child. In dialogue with Hannah Arendt’s thinking on natality, amor mundi and education, the third chapter shows that the child calls attention to how Coetzee’s working through of the uncertainties of new beginnings is closely linked to a care for the world. Finally, the fourth and fifth chapters engage with how Coetzee’s latest works gesture towards infancy and perpetual study, and, relatedly, towards the redemptive potential of a nonposition beyond the taxonomies of Western metaphysics. Ultimately, the thesis hopes to demonstrate the critical possibilities in thinking about—and with—childlike openness and childish experimentation when approaching the writing and reading of the work of J.M. Coetzee.
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| 6. |
- Helgesson, Stefan, 1966-, et al.
(författare)
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Introduction : World Literature in the Making
- 2015
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Ingår i: Institutions of World Literature. - London : Routledge. - 9781138832541 - 9781317565574 ; , s. 1-20
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Bokkapitel (refereegranskat)
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| 7. |
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| 8. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 9. |
- Nowak-Sliwinska, Patrycja, et al.
(författare)
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Consensus guidelines for the use and interpretation of angiogenesis assays
- 2018
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Ingår i: Angiogenesis. - : Springer. - 0969-6970 .- 1573-7209. ; 21:3, s. 425-532
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Forskningsöversikt (refereegranskat)abstract
- The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.
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| 10. |
- Prins, Jonne T H, et al.
(författare)
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Surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures following cardiopulmonary resuscitation: An international, retrospective matched case-control study.
- 2022
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Ingår i: The journal of trauma and acute care surgery. - 2163-0763. ; 93:6, s. 727-735
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Tidskriftsartikel (refereegranskat)abstract
- The presence of six or more rib fractures or a displaced rib fracture due to cardiopulmonary resuscitation (CPR) has been associated with longer hospital and intensive care unit (ICU) length of stay (LOS). Evidence on the effect of surgical stabilization of rib fractures (SSRF) following CPR is limited. This study aimed to evaluate outcomes after SSRF versus nonoperative management in patients with multiple rib fractures after CPR.An international, retrospective study was performed in patients who underwent SSRF or nonoperative management for multiple rib fractures following CPR between January 1, 2012, and July 31, 2020. Patients who underwent SSRF were matched to nonoperative controls by cardiac arrest location and cause, rib fracture pattern, and age. The primary outcome was ICU LOS.Thirty-nine operatively treated patient were matched to 66 nonoperatively managed controls with comparable CPR-related characteristics. Patients who underwent SSRF more often had displaced rib fractures (n = 28 [72%] vs. n = 31 [47%]; p = 0.015) and a higher median number of displaced ribs (2 [P 25 -P 75 , 0-3] vs. 0 [P 25 -P 75 , 0-3]; p = 0.014). Surgical stabilization of rib fractures was performed at a median of 5 days (P 25 -P 75 , 3-8 days) after CPR. In the nonoperative group, a rib fixation specialist was consulted in 14 patients (21%). The ICU LOS was longer in the SSRF group (13 days [P 25 -P 75 , 9-23 days] vs. 9 days [P 25 -P 75 , 5-15 days]; p = 0.004). Mechanical ventilator-free days, hospital LOS, thoracic complications, and mortality were similar.Despite matching, those who underwent SSRF over nonoperative management for multiple rib fractures following CPR had more severe consequential chest wall injury and a longer ICU LOS. A benefit of SSRF on in-hospital outcomes could not be demonstrated. A low consultation rate for rib fixation in the nonoperative group indicates that the consideration to perform SSRF in this population might be associated with other nonradiographic or injury-related variables.Therapeutic/Care Management; Level III.
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