| 1. |
- Bushati, M., et al.
(author)
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The current practice of cytoreductive surgery and HIPEC for colorectal peritoneal metastases : Results of a worldwide web-based survey of the Peritoneal Surface Oncology Group International (PSOGI)
- 2018
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In: European Journal of Surgical Oncology. - : ELSEVIER SCI LTD. - 0748-7983 .- 1532-2157. ; 44:12, s. 1942-1948
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Journal article (peer-reviewed)abstract
- Background: At present, selected patients with resectable colorectal peritoneal metastases (CRC-PM) are increasingly treated with a combination therapy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). The aim of this study was to investigate the current worldwide practice.Methods: HIPEC experts from 19 countries were invited through the Peritoneal Surface Oncology Group International (PSOGI) to complete an online survey concerning their personal expertise and current hospital and country wide practice.Results: It is estimated that currently more than 3800 patients with CRC-PM (synchronous and metachronous) are annually treated with CRS and HIPEC in 430 centers. Integration of CRS and HIPEC in national guidelines varies, resulting in large treatment disparities between countries. Amongst the experts, there was general agreement on issues related to indication, surgical technique and follow up but less on systemic chemotherapy or proactive strategies.Conclusion: This international survey demonstrates that CRS and HIPEC is now performed on a large scale for CRC-PM patients. Variation in treatment may result in heterogeneity in surgical and oncological outcomes, emphasising the necessity to reach consensus on several issues of this comprehensive procedure. Future initiatives directed at achieving an international consensus statement are needed.
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| 2. |
- Ngan-Tillard, D., et al.
(author)
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Under Pressure: A Laboratory Investigation into the Effects of Mechanical Loading on Charred Organic Matter in Archaeological Sites
- 2015
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In: Conservation and Management of Archaeological Sites. - : Informa UK Limited. - 1753-5522 .- 1350-5033. ; 17:2, s. 122-142
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Journal article (peer-reviewed)abstract
- The present publication investigates what happens to archaeological sites when they are built over. Focus is put on the degradation of charred organic materials by static loading. It is assumed that materials lose archaeological value if their fragments become too small to be recovered, or too distorted to be classified at species level. Several charred ecofacts of a few millimetres in size (wood fragments, hazelnut shells, and seeds) have been selected and subjected to individual particle strength tests. Assemblages of these particles have also been compressed one-dimensionally and scanned at several stages of testing using laboratory based X-ray microtomography. Microscopic damage by splitting or crushing is found to be limited at the macroscopic yield stress. It initiated at stresses less than 80 kPa for the weakest assemblages, and in all cases at stresses below 320 kPa. (80 kPa represents the load of a 6 m high sand embankment on soft soil that has half-settled underneath the groundwater table, while 320 kPa corresponds to stresses applied beneath the pile foundation level of high-rise buildings.) Sand seeded with charred particles has also been tested to illustrate the beneficial effect of embedment of charred particles in sand during static one dimensional loading.
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