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- Chialva, Diego, et al.
(författare)
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Deforming, revolving and resolving : New paths in the string theory landscape
- 2008
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer Science and Business Media LLC. - 1126-6708 .- 1029-8479. ; 02
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we investigate the properties of series of vacua in the string theory landscape. In particular, we study minima to the flux potential in type IIB compactifications on the mirror quintic. Using geometric transitions, we embed its one-dimensional complex structure moduli space in that of another Calabi-Yau with h1,1 = 86 and h2,1 = 2. We then show how to construct infinite series of continuously connected minima to the mirror quintic potential by moving into this larger moduli space, applying its monodromies, and moving back. We provide an example of such series, and discuss their implications for the string theory landscape
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| 3. |
- Danielsson, Ulf, et al.
(författare)
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4D black holes and holomorphic factorization of the 0A matrix model
- 2005
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Ingår i: Journal of High Energy Physics. ; 0510, s. 046-
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Tidskriftsartikel (refereegranskat)abstract
- n this letter, we relate the free energy of the 0A matrix model to the sum of topological and anti-topological string amplitudes. For arbitrary integer multiples of the matrix model self-dual radius we describe the geometry on which the corresponding topological string propagates. This geometry is not the one that follows from the usual ground ring analysis, but in a sense its "holomorphic square root". Mixing of terms for different genus in the matrix model free energy yields one-loop terms compatible with type II strings on compact Calabi-Yau target spaces. As an application, we give an explicit example of how to relate the 0A matrix model free energy to that of a four-dimensional black hole in type IIB theory, compactified on a compact Calabi-Yau. Variables, Legendre transforms, and large classical terms on both sides match perfectly.
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| 6. |
- Larsen, Kasper, 1983-, et al.
(författare)
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MHV, CSW and BCFW : field theory structures in string theory amplitudes
- 2008
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer Science and Business Media LLC. - 1126-6708 .- 1029-8479. ; 11:015, s. 1-59
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Tidskriftsartikel (refereegranskat)abstract
- Motivated by recent progress in calculating field theory amplitudes, we study applications of the basic ideas in these developments to the calculation of amplitudes in string theory. We consider in particular both non-Abelian and Abelian open superstring disk amplitudes in a flat space background, focusing mainly on the four-dimensional case. The basic field theory ideas under consideration split into three separate categories. In the first, we argue that the calculation of α'-corrections to MHV open string disk amplitudes reduces to the determination of certain classes of polynomials. This line of reasoning is then used to determine the α'3-correction to the MHV amplitude for all multiplicities. A second line of attack concerns the existence of an analog of CSW rules derived from the Abelian Dirac-Born-Infeld action in four dimensions. We show explicitly that the CSW-like perturbation series of this action is surprisingly trivial: only helicity conserving amplitudes are non-zero. Last but not least, we initiate the study of BCFW on-shell recursion relations in string theory. These should appear very naturally as the UV properties of the string theory are excellent. We show that all open four-point string amplitudes in a flat background at the disk level obey BCFW recursion relations. Based on the naturalness of the proof and some explicit results for the five-point gluon amplitude, it is expected that this pattern persists for all higher point amplitudes and for the closed string.
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| 7. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 8. |
- Ried, Janina S., et al.
(författare)
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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
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| 9. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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