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Träfflista för sökning "WFRF:(Wagner Jendrik) "

Search: WFRF:(Wagner Jendrik)

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  • Gajdoš, Matúš, et al. (author)
  • Chiral Alcohols from Alkenes and Water: Directed Evolution of a Styrene Hydratase
  • 2023
  • In: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 62:7
  • Journal article (peer-reviewed)abstract
    • Enantioselective synthesis of chiral alcohols through asymmetric addition of water across an unactivated alkene is a highly sought-after transformation and a big challenge in catalysis. Herein we report the identification and directed evolution of a fatty acid hydratase from Marinitoga hydrogenitolerans for the highly enantioselective hydration of styrenes to yield chiral 1-arylethanols. While directed evolution for styrene hydration was performed in the presence of heptanoic acid to mimic fatty acid binding, the engineered enzyme displayed remarkable asymmetric styrene hydration activity in the absence of the small molecule activator. The evolved styrene hydratase provided access to chiral alcohols from simple alkenes and water with high enantioselectivity (>99 : 1 e.r.) and could be applied on a preparative scale.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Engqvist, Martin, 19 ... (1)
Gajdoš, Matúš (1)
Wagner, Jendrik (1)
Ospina, Felipe (1)
Köhler, Antonia (1)
Hammer, Stephan C. (1)
University
Chalmers University of Technology (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Engineering and Technology (1)
Year
2023 (1)

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