| 1. |
- Kanai, M, et al.
(author)
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- 2023
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swepub:Mat__t
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| 2. |
- Niemi, MEK, et al.
(author)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
- Murphy, T., et al.
(author)
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VAST: An ASKAP Survey for Variables and Slow Transients
- 2013
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In: Publications of the Astronomical Society of Australia. - : Cambridge University Press (CUP). - 1323-3580 .- 1448-6083. ; 30
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Journal article (peer-reviewed)abstract
- The Australian Square Kilometre Array Pathfinder (ASKAP) will give us an unprecedented opportunity to investigate the transient sky at radio wavelengths. In this paper we present VAST, an ASKAP survey for Variables and Slow Transients. VAST will exploit the wide-field survey capabilities of ASKAP to enable the discovery and investigation of variable and transient phenomena from the local to the cosmological, including flare stars, intermittent pulsars, X-ray binaries, magnetars, extreme scattering events, interstellar scintillation, radio supernovae, and orphan afterglows of gamma-ray bursts. In addition, it will allow us to probe unexplored regions of parameter space where new classes of transient sources may be detected. In this paper we review the known radio transient and variable populations and the current results from blind radio surveys. We outline a comprehensive program based on a multi-tiered survey strategy to characterise the radio transient sky through detection and monitoring of transient and variable sources on the ASKAP imaging timescales of 5 s and greater. We also present an analysis of the expected source populations that we will be able to detect with VAST.
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| 5. |
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| 6. |
- Arthur, Rohan, et al.
(author)
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Optimising the production cost of urea from black liquor
- 2014
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In: Pulp & paper, bioenergy, bioproducts. - Bundoora : Appita Inc. - 9780987168443 ; , s. 91-95
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Conference paper (peer-reviewed)abstract
- A conceptual design of an integrated facility for the co-production of ammonia and electricity from black liquor gasification has been studied. The integrated process exchanges black and green liquor, steam, electricity and sulfur with the adjacent Kraft pulp mill. A triple bottom line analysis has indicated that a competitive ammonia price (A$516/t) can be realized for a relatively small scale production 20ktpa of NH3 with an internal rate of return of 13.7%. This is achieved through a novel process design which also produces electricity and steam for the pulp mill. The plant has a carbon footprint at 50% of the average and 33% below world best practice for NH3. Social benefits are also predicted for the regional community.
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| 7. |
- Douse, Christopher H., et al.
(author)
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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
- 2020
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Journal article (peer-reviewed)abstract
- The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8 and Periphilin — contribute to assembly and targeting of the complex remains unknown. Here, we define the biochemical basis of HUSH assembly and find that its modular architecture resembles the yeast RNA-induced transcriptional silencing complex. TASOR, the central HUSH subunit, associates with RNA processing components. TASOR is required for H3K9me3 deposition over LINE-1 repeats and repetitive exons in transcribed genes. In the context of previous studies, this suggests that an RNA intermediate is important for HUSH activity. We dissect the TASOR and MPP8 domains necessary for transgene repression. Structure-function analyses reveal TASOR bears a catalytically-inactive PARP domain necessary for targeted H3K9me3 deposition. We conclude that TASOR is a multifunctional pseudo-PARP that directs HUSH assembly and epigenetic regulation of repetitive genomic targets.
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| 8. |
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| 9. |
- Jayson, G.C., et al.
(author)
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Phase I investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer
- 2005
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In: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 41:4, s. 555-563
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Journal article (peer-reviewed)abstract
- We assessed the tolerability, safety, pharmacokinetics and dose-limiting toxicity (DLT) of the recombinant humanized IgG4 anti-vascular endothelial growth factor (VEGF) monoclonal antibody, HuMV833, in patients with advanced cancer. Cohorts of patients with progressive solid tumours received escalating doses of HuMV833 as a 1-h intravenous (I.V.) infusion on days 1, 15, 22, and 29. Twenty patients (median Eastern Cooperative Oncology Group (ECOG) score 1) were accrued. HuMV833 infusions were well tolerated and there were no grade III or IV toxicities definitely related to the antibody. Grade I or II toxicities probably related to the antibody included fatigue, dyspnoea and rash. There were two episodes of asymptomatic hypocalcaemia, one at grade III and one grade IV, which were recorded in early follow-up. There were eight grade I episodes of asymptomatic elevation of activated partial thromboplastin time (APTT) and two grade III events, one in a patient receiving 1 mg/kg and the other receiving extended doses of 10 mg/kg. Pharmacokinetic analysis revealed a non-linear kinetic and an elimination half-life of between 8.2 (0.3 mg/kg) and 18.7 (10 mg/kg) days. One patient with ovarian cancer experienced a partial response (PR) of 9 months duration and eight had disease stabilisation (SD) including one patient with colorectal carcinoma whose disease was stable for 14 months. In 13 of the 14 samples taken from 12 patients, the plasma concentration of hepatocyte growth factor (HGF) was reduced 24 h after drug administration. HuMV833 is safe and lacked DLT at doses up to 10 mg/kg on this schedule. Multiple doses were well tolerated, despite occasional asymptomatic elevations in APTT. By combining pharmacokinetic, pharmacodynamic and toxicity data, we can identify doses of 1 and 3 mg/kg for further investigation. HuMV833 appears to possess some clinical activity. © 2004 Published by Elsevier Ltd.
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| 10. |
- Schinke, Robert J., et al.
(author)
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International society of sport psychology position stand : elite athlete mental health revisited
- 2024
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In: International Journal of Sport and Exercise Psychology. - Abingdon : Routledge. - 1612-197X .- 1557-251X. ; 22:4, s. 775-801
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Journal article (peer-reviewed)abstract
- Athlete mental health, though long present within research and practice, has recently become a central topic area within the sport and exercise psychology field. The International Society of Sport Psychology has been at the forefront of these discussions, evidenced by a foundational position stand in 2018 and subsequent consensus statements derived from international think tanks. Within this position stand, contributors from the international community spanning five continents collaborated to present key, updated ideas and emerging concepts relating to clinical understandings of athlete mental health, trends in athlete mental health status, the role of the sport environment, mental health in relation to athlete careers, the global treatment of athlete mental health, cultural considerations in relation to understanding this topic, and nine synthesising postulates. © 2024 International Society of Sport Psychology.
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