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Search: WFRF:(Wahlstedt H)

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  • Behm, M, et al. (author)
  • Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development
  • 2017
  • In: Journal of cell science. - : The Company of Biologists. - 1477-9137 .- 0021-9533. ; 130:4, s. 745-753
  • Journal article (peer-reviewed)abstract
    • Adenosine to inosine (A-to-I) RNA editing is important for a functional brain and most known sites of selective RNA editing has been found to diversify the number of protein isoforms involved in neurotransmission. In absence of the active editing enzymes, ADAR1 or ADAR2, mice fail to survive until adulthood. Nuclear A-to-I editing of neuronal transcripts is regulated during brain development with low levels in the embryo and a dramatic increase after birth. Yet, little is known about the mechanisms that regulate editing during development. Here we demonstrate lower levels of ADAR2 in the nucleus of immature neurons than in mature neurons. We show that importin-α4, which increases during neuronal maturation, interacts with ADAR2 and contributes to the editing efficiency by bringing it into the nucleus. Moreover, we detect an increased number of interactions between ADAR2 and the nuclear isomerase Pin1 as neurons mature, which contribute to ADAR2 protein stability. Together, these findings explain how nuclear editing of substrates important for neuronal function can increase as the brain develops.
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  • Nyqvist, D, et al. (author)
  • Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts
  • 2005
  • In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 54:8, s. 2287-2293
  • Journal article (peer-reviewed)abstract
    • Pancreatic islet transplantation has emerged as a therapy for type 1 diabetes and is today performed using both freshly isolated and cultured islets. Islet blood vessels are disrupted during islet isolation; therefore, proper revascularization of the transplanted islets is of great importance for islet graft function and survival. We have studied intraislet endothelial cells after islet isolation, during islet culture, and following islet transplantation. By isolating islets from the transgenic Tie2-GFP (green fluorescent protein) mouse, characterized by an endothelial cell–specific expression of GFP, living endothelial cells could be studied in intact islets utilizing two-photon laser-scanning microscopy (TPLSM). Intraislet endothelial cells were found to survive islet transplantation but to rapidly disappear during islet culture. By transplanting freshly isolated Tie2-GFP islets and applying a novel ex vivo model for simultaneous perfusion and TPLSM imaging of the graft-bearing kidneys, GFP fluorescent endothelial cells were found to extensively contribute to vessels within the islet graft vasculature. Real-time imaging of the flow through the islet graft vasculature confirmed that the donor-derived vessels were functionally integrated. Hence, intraislet endothelial cells have the capability of participating in revascularization of pancreatic islets subsequent to transplantation. Therefore, preservation of intraislet endothelial cell mass may improve long-term graft function.
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  • Result 1-7 of 7

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