| 1. |
- Gu, Jian, et al.
(author)
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TGF-beta-Induced CD4(+) Foxp3(+) T Cells Attenuate Acute Graft-versus-Host Disease by Suppressing Expansion and Killing of Effector CD8(+) Cells
- 2014
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In: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 193:7, s. 3388-3397
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Journal article (peer-reviewed)abstract
- The use of TGF-beta-induced CD4(+) Foxp3(+) T cells (induced regulatory T cells [iTregs]) is an important prevention and treatment strategy in autoimmune diseases and other disorders. However, the potential use of iTregs as a treatment modality for acute graft-versus-host disease (aGVHD) has not been realized because they may be unstable and less suppressive in this disease. We restudied the ability of iTregs to prevent and treat aGVHD in two mouse models. Our results showed that, as long as an appropriate iTreg-generation protocol is used, these iTregs consistently displayed a potent ability to control aGVHD development and reduce mortality in the aGVHD animal models. iTreg infusion markedly suppressed the engraftment of donor CD8(+) cells and CD4(+) cells, the expression of granzyme A and B, the cytotoxic effect of donor CD8(+) cells, and the production of T cell cytokines in aGVHD. Therefore, we conclude that as long as the correct methods for generating iTregs are used, they can prevent and even treat aGVHD.
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| 2. |
- Wang, Zheng, et al.
(author)
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Trade-off effect of hydrogen-bonded dopant-free hole transport materials on performance of inverted perovskite solar cells
- 2024
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In: Nano Energy. - 2211-2855. ; 128
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Journal article (peer-reviewed)abstract
- Benefiting from their ordered orientation and superior stability compared to traditional conjugated materials, hydrogen bonding (HB)-induced H-aggregates in organic small molecule hole-transport materials (HTMs) hold a big potential for high-performance inverted perovskite solar cells (IPSCs). However, H-aggregates can also lead to excessive face-aggregation by forming the gaps between aggregates, which is in turn unfavorable for charge mobility and thus for the overall device performance. Herein, we design and synthesize a new set of HB-containing triphenylamine-based small molecules to tailor the degree of H-aggregation, namely O1 (without HB), O2 (unilateral HB unit), and O3 (bilateral HB units). These HTMs make a clear trade-off effect on the charge mobility within the HTM and the interfacial properties of perovskite and HTM. Although the interfacial hole extraction process is promoted upon the HB-functionalized interface, the best performance of IPSCs is still achieved by O1 HTM, which is mainly influenced by the higher hole mobility without HB-induced H-aggregates. Nevertheless, the photo stability of as-fabricated devices is effectively improved upon the HB passivation effect on the interface of HTM (O2 or O3) and perovskite, as well as the better quality of atop perovskite layers with less grain boundary compared to the reference case (O1).
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| 3. |
- Geng, Longlong, et al.
(author)
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Valence-mixed CuOx-nanoparticles anchored biomass-based carbon nanofiber for boosting toxic nitroarenes reduction : Synthesis, kinetics, and mechanisms
- 2022
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In: Journal of Environmental Chemical Engineering. - : Elsevier. - 2213-3437. ; 10:6
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Journal article (peer-reviewed)abstract
- The rational modulation of metal catalysts with tailorable valence and redox properties is a promising strategy for further improving their catalytic performance. Herein, an environment-friendly grafting and thermal strategy was adopted to immobilize copper oxides nanoparticles on carbon nanofiber (CuOx/CF). Benefiting from the defect-rich surface and valence-mixed composition of the CuOx species, the optimized sample CuOx/CF-3 exhibits superb activity for the catalytic reduction of toxic nitrophenols. The complete conversion took only 1 min and an outstanding rate constant (k) of 112.7 × 10-3 s-1 was achieved under mild conditions (25 °C and 1 atm). Kinetic and recycle experiments demonstrated that the whole catalytic process obeys a pseudo-order kinetic, and the catalyst could maintain high conversion even after 13 successive recycles. These results demonstrate that CuOx/CF-3 is an alternative catalyst to noble metals, providing superb catalytic efficiency and stability in the reduction of toxic nitrophenols, and it can be expanded to develop other noble-metal-free catalysts for various applications.
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| 4. |
- Liang, Chen, et al.
(author)
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Trust-Based Distributed Kalman Filtering for Target Tracking under Malicious Cyber Attacks
- 2019
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In: Information Fusion. - : Elsevier BV. - 1566-2535. ; 46, s. 44-50
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Journal article (peer-reviewed)abstract
- As one of the widely used applications in wireless sensor networks, target tracking has attracted considerable attention. Although many tracking techniques have been developed, it is still a challenging problem if the network is under cyber attacks. Inaccurate or false information is maliciously broadcast by the compromised nodes to their neighbors. They are likely to threaten the security of the system and result in performance deterioration. In this paper, a distributed Kalman filtering technique with trust-based dynamic combination strategy is developed to improve resilience against cyber attacks. Furthermore, it is efficient in terms of communication load, only local instantaneous estimates are exchanged with the neighboring nodes. Numerical results are provided to evaluate the performance of the proposed approach by considering random, false data injection and replay attacks.
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| 5. |
- Lin, Shangrong, et al.
(author)
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Underestimated Interannual Variability of Terrestrial Vegetation Production by Terrestrial Ecosystem Models
- 2023
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In: Global Biogeochemical Cycles. - 0886-6236. ; 37:4
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Journal article (peer-reviewed)abstract
- Vegetation gross primary production (GPP) is the largest terrestrial carbon flux and plays an important role in regulating the carbon sink. Current terrestrial ecosystem models (TEMs) are indispensable tools for evaluating and predicting GPP. However, to which degree the TEMs can capture the interannual variability (IAV) of GPP remains unclear. With large data sets of remote sensing, in situ observations, and predictions of TEMs at a global scale, this study found that the current TEMs substantially underestimate the GPP IAV in comparison to observations at global flux towers. Our results also showed the larger underestimations of IAV in GPP at nonforest ecosystem types than forest types, especially in arid and semiarid grassland and shrubland. One cause of the underestimation is that the IAV in GPP predicted by models is strongly dependent on canopy structure, that is, leaf area index (LAI), and the models underestimate the changes of canopy physiology responding to climate change. On the other hand, the simulated interannual variations of LAI are much less than the observed. Our results highlight the importance of improving TEMs by precisely characterizing the contribution of canopy physiological changes on the IAV in GPP and of clarifying the reason for the underestimated IAV in LAI. With these efforts, it may be possible to accurately predict the IAV in GPP and the stability of the global carbon sink in the context of global climate change.
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| 6. |
- Ma, Sugang, et al.
(author)
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An Efficient GPS-Free Vehicle Localization Algorithm Using Single Roadside Unit and Receiver
- 2018
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In: Proceedings - 2018 International Conference on Networking and Network Applications, NaNA 2018. ; , s. 310-313
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Conference paper (peer-reviewed)abstract
- Accurate vehicle localization is critical for connected and autonomous vehicles of the future. But it is challenging, especially in global positioning system (GPS) denied or urban environments. In this paper, we propose an efficient GPS-free vehicle localization algorithm by exploiting vehicle-to infrastructure communications. It is an on-board odometer and inertial measurement unit (IMU) assisted and single roadside unit (RSU) based approach. The available RSU position, speed vector and distance information between the RSU and vehicle are formulated as an over-determined system of linear equations. The linear least squares method is then utilized to estimate the vehicle position in a computationally efficient manner.
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| 7. |
- Meng, Fandong, et al.
(author)
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Consistent time allocation fraction to vegetation green-up versus senescence across northern ecosystems despite recent climate change
- 2024
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In: Science Advances. - 2375-2548. ; 10:23
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Journal article (peer-reviewed)abstract
- Extended growing season lengths under climatic warming suggest increased time for plant growth. However, research has focused on climatic impacts to the timing or duration of distinct phenological events. Comparatively little is known about impacts to the relative time allocation to distinct phenological events, for example, the proportion of time dedicated to leaf growth versus senescence. We use multiple satellite and ground-based observations to show that, despite recent climate change during 2001 to 2020, the ratio of time allocated to vegetation green-up over senescence has remained stable [1.27 (± 0.92)] across more than 83% of northern ecosystems. This stability is independent of changes in growing season lengths and is caused by widespread positive relationships among vegetation phenological events; longer vegetation green-up results in longer vegetation senescence. These empirical observations were also partly reproduced by 13 dynamic global vegetation models. Our work demonstrates an intrinsic biotic control to vegetation phenology that could explain the timing of vegetation senescence under climate change.
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| 8. |
- Mårtensson, Linda, et al.
(author)
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Determining maximal tolerable dose of the monoclonal antibody BR96 labeled with 90Y or 177Lu in rats: establishment of a syngeneic tumor model to evaluate means to improve radioimmunotherapy.
- 2005
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In: Clinical Cancer Research. - 1078-0432. ; 11:19 Pt 2, s. 7104-7108
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Journal article (peer-reviewed)abstract
- Purpose: To evaluate therapeutic strategies, it is essential to use biological models reflecting important aspects of the clinical situation. The aim of the present study was to compare the maximal tolerable dose of the monoclonal antibody BR96 labeled with Y-90 or Lu-177 in immunocompetent rats. Maximal tolerable dose was defined as the highest activity that allows 100% of the animals to survive without clinical signs, such as infections, bleeding, or diarrhea, and with < 20% loss in body weight. Experimental Design: Increasing activity levels of BR96 labeled with Y-90 or Lu-177 were administered to groups of rats. Blood parameters, body weight, and general performance were monitored for 8 weeks. Results: Two days postinjection, all groups had decreased leukocyte counts down to 5% to 15% of initial values. Initiation of recovery (at 14-21 days) showed a dose-response relationship. All groups, except the group given the highest activity of Y-90 had complete resolution in their leukopenia. The decrease in platelets was delayed to days 7 to 14 postinjection with a dose dependent response regarding both severity of the nadir (10-40% of initial value) and the start of recovery. Animals in the groups given the highest activities of both Y-90 and Lu-177 exhibited skin infections on day 21. Conclusions: The results showed good reproducibility and dose-dependent toxicity for both radionuclides, indicating that the maximal tolerable dose for Lu-177 - BR96 (1,000 MBq/kg) is 1.7 times that for Y-90 - BR96 (600 MBq/kg) in rats. This model makes it feasible to evaluate strategies to escalate therapeutic doses to tumors without increasing normal tissue toxicity.
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| 9. |
- Wang, Lei, et al.
(author)
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Exploring Bronsted acids confined in the 10-ring channels of the zeolite ferrierite
- 2018
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In: CrystEngComm. - : Royal Society of Chemistry (RSC). - 1466-8033. ; 20:6, s. 699-702
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Journal article (peer-reviewed)abstract
- Locations of Bronsted acids confined in the 10-ring channels of ferrierite have been unravelled by refining structural models of as-made and probe-molecule-adsorbed samples against powder X-ray diffraction data, respectively. By analysing both refinement results, it is suggested that Bronsted acid sites can be tailored by controlling the distribution of inorganic ions.
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| 10. |
- Wang, Zhongmin, et al.
(author)
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Application of extracorporeal immunoadsorption to reduce circulating blood radioactivity after intraperitoneal administration of indium-111-HMFG1-biotin.
- 2002
-
In: Cancer. - : Wiley. - 1097-0142 .- 0008-543X. ; 94:4 Suppl, s. 1287-1292
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Journal article (peer-reviewed)abstract
- BACKGROUND: Extracorporeal immunoadsorption (ECAT) is a method of reducing activity in radiosensitive organs by removing excess monoclonal antibodies (MAbs) from the blood. Previously, the authors experimentally evaluated ECAT based on the avidin-biotin concept after intravenous administration of radioimmunoconjugates. The aim of the current study was to determine whether ECAT could be used to reduce activity after intraperitoneal (i.p.) administration of indium-111((111)In)-HMFG1-biotin in rats, and to compare the pharmacokinetics of (111)In-HMFG1 with or without attached biotin after i.p. injection. METHODS: HMFG1, a murine immunoglobulin G(1) MAb that recognizes an epitope on the polymorphic epithelial mucin (PEM) antigen, was labeled with (111)In and then biotinylated. ECAT was explored from unseparated blood using an avidin-agarose adsorption column. Thirty rats were used as controls and 13 underwent ECAT. The whole-body (WB), blood, and organ activity were monitored. RESULTS: The binding capacity of (111)In-HMFG1-biotin to avidin was high. Biotinylation did not enhance the excretion of HMFG1. When ECAT was employed, the WB and blood radioactivity were reduced by 35-40% (P < 0.05) and 75--86% (P < 0.01), respectively. After the completion of ECAT, the activity uptake in organs was significantly decreased. CONCLUSIONS: ECAT was successfully applied after i.p. injection of the (111)In-HMFG-biotin MAb to reduce the radioactivity in the WB, blood, and radiosensitive organs. Due to redistribution of the radiolabeled MAbs during and after the completion of ECAT, the adsorption may have been prolonged or repeated. Biotinylation did not significantly change the biodistribution of the (111)In-HMFG1 in rats after intraperitoneal injection.
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