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- Stefánsson, Hreinn, et al.
(author)
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Fractionation of the thylakoid membrane from Dunaliella salina – heterogeneity is found in Photosystem I over a broad range of growth irradiance
- 1997
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In: Biochimica et Biophysica Acta - Bioenergetics. - 0005-2728. ; 1320:3, s. 235-246
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Journal article (peer-reviewed)abstract
- Thylakoids from the green alga, Dunaliella salina, were fragmented by sonication and the appressed grasna membranes separated from stroma lamellae by partitioning in aqueous two-phase systems. The concentration and antenna size of Photosystem I in the two membrane domains were determined for cultures grown at three different light intensities. Although the antenna size of both PS is decreased with increasing growth irradiance, the antenna size of Photosystem I in the grana was approximately 25-30% greater than the antenna size of Photosystem I in the stroma lamellae. Counter-current distribution analysis of sonicated thylakoids revealed that the amount of stroma lamellae increased whereas the amount of the stacked membranes decreased at higher growth irradiance. The overall decrease in the antenna size of PS I, in D. salina, at higher light intensities can therefore be explained by the combined effect of a decrease in the antenna size of Photosystem I, both in the grana and the stroma lamellae, and a relative increase in the amount of stroma lamellae which has smaller Photosystem I antennae than the Photosystem I centers found in the grana. Light-induced protein phosphorylation increased the relative amount of the stroma lamella fraction. This is interpreted as a result of partial unstacking of the grana. It is suggested that this may be a mechanism for increasing the cyclic electron transport around Photosystem I.
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- Weibull, Caroline E., et al.
(author)
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Survival by First-line Treatment Type and Timing of Progression Among Follicular Lymphoma Patients : A National Population-based Study in Sweden
- 2023
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In: HemaSphere. - : Wolters Kluwer. - 2572-9241. ; 7:3
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Journal article (peer-reviewed)abstract
- In follicular lymphoma (FL), progression of disease <= 24 months (POD24) has emerged as an important prognostic marker for overall survival (OS). We aimed to investigate survival more broadly by timing of progression and treatment in a national population-based setting. We identified 948 stage II-IV indolent FL patients in the Swedish Lymphoma Register diagnosed 2007-2014 who received first-line systemic therapy, followed through 2020. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated by first POD at any time during follow-up using Cox regression. OS was predicted by POD using an illness-death model. During a median follow-up of 6.1 years (IQR: 3.5-8.4), 414 patients experienced POD (44%), of which 270 (65%) occurred <= 24 months. POD was represented by a transformation in 15% of cases. Compared to progression-free patients, POD increased all-cause mortality across treatments, but less so among patients treated with rituximab(R)-single (HR = 4.54, 95% CI: 2.76-7.47) than R-chemotherapy (HR = 8.17, 95% CI: 6.09-10.94). The effect of POD was similar following R-CHOP (HR = 8.97, 95% CI: 6.14-13.10) and BR (HR = 10.29, 95% CI: 5.60-18.91). The negative impact of POD on survival remained for progressions up to 5 years after R-chemotherapy, but was restricted to 2 years after R-single. After R-chemotherapy, the 5-year OS conditional on POD occurring at 12, 24, and 60 months was 34%, 46%, and 57% respectively, versus 78%, 82%, and 83% if progression-free. To conclude, POD before but also beyond 24 months is associated with worse survival, illustrating the need for individualized management for optimal care of FL patients.
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- Weibull, Louise, 1973-
(author)
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Emotion matters : Emotion management in Swedish Peace Support Operations
- 2012
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Doctoral thesis (other academic/artistic)abstract
- The thesis makes an overall contribution to the qualitative research on soldiers’ experiences from service primarily in low-intensity mission areas, this operational environment being placed within a framework of emotion sociology. The central argument put forward states that even on this type of mission the emotional demands are considerable, and that the need for emotional management in Peace Support Operations (PSO) should therefore generally follow other demarcations than the formal military divisions of high and low intensity conflicts respectively. In contrast to the prevalent view stating that the successful soldier is someone with emotional control in the sense that he ‘lacks’ feeling towards what he is doing, this thesis argues that soldiers’ emotion management work when choosing, modelling, managing, and displaying the ‘right’ emotional expression is what it takes to get the job done. Further, the thesis argues that emotion management demands are not restricted to the tour of service. Returning home often involves feeling both cognitively and emotionally disorientated, even if the mission has been militarily quite uneventful. A new theoretical concept, Post-Deployment Disorientation (PDD), is introduced to explain and highlight the origin of these feelings. PDD is not a diagnosis, however, but a term reserved for a phenomenon invisible in statistics that likely confronts the majority of Swedish soldiers on return.The thesis comprises four essays and draws on qualitative data collected mainly from soldiers deployed to Kosovo and Liberia in 2006/2007. Two of the essays also include data from Afghanistan. Jointly, the four essays help us understand that from an emotion management perspective, serving abroad is both a varied and challenging experience. Nevertheless, the informants seem to muddle through many difficulties and the study broadly confirms Bolton’s (2005) accounts of the multi-talented emotional actor, who is quite capable of handling contradiction while negotiating feeling rules. However, this does not mean an adjustment with negligible effort or without substantial emotional costs.
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