| 1. |
- Åström, Lennart, et al.
(author)
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S-phase fraction related to prognosis in localised prostate cancer. No specific significance of chromosome 7 gain or deletion of 7q31.1.
- 1998
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In: International journal of cancer. Journal international du cancer. - 0020-7136. ; 79:6, s. 553-9
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Journal article (peer-reviewed)abstract
- A flow-cytometric (FCM) and fluorescence in situ hybridization (FISH) study was performed in 153 patients with clinically localised prostate cancer (PC) to evaluate retrospectively the prognostic significance of DNA ploidy, S-phase fraction (SPF) and chromosome 7 copy number. Deletions in 7q31.1 were analysed in a subset of 26 tumours. The mean follow-up time was 6 years (range 4-16 years). Twelve cases of benign prostatic hyperplasia (BPH) were studied as a control. Chromosome 7 enumeration and deletion studies were conducted using the alpha-satellite D7Z1 probe and a cosmid probe specific for the marker D7S522 on 7q31.1. Higher SPF was associated with shorter overall survival and shorter time to local progression and metastasis. Near diploid (DNA index 1.05-1.20) cases had a lower frequency of metastases and lower Gleason scores than aneuploid cases. Increased absolute chromosome 7 copy number (centromere count) was associated with higher Gleason score, higher SPF and shorter local progression-free and prostate cancer survival. Absolute chromosome 7 copy number was concordant with FCM DNA ploidy in the majority (75%) of cases. Relative gain or loss of chromosome 7 (centromere counts compared to ploidy) was infrequent, and no correlation was found with clinical parameters. Deletions in 7q31.1 were infrequent. Our results indicate that in localised PC (i) SPF is a prognostic factor, (ii) absolute chromosome 7 copy number is concordant with the ploidy status of the tumour (relative gain or loss of chromosome 7 is infrequent and has no independent prognostic value) and (iii) the frequency of deletions in 7q31.1 is low and not correlated with clinical outcome.
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| 2. |
- Hultborn, Ragnar, 1946, et al.
(author)
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Prevalence of Klinefelter's syndrome in male breast cancer patients
- 1997
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In: Anticancer Res. - 0250-7005. ; 17:6D, s. 4293-7
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Journal article (peer-reviewed)abstract
- Klinefelter's syndrome (KS, XXY) as a risk factor for developing breast cancer was evaluated in a retrospective study of 93 unselected male breast cancer patients from the Healthcare region of Western Sweden. Archival normal material from lymph nodes or skin and subcutaneous tissue was examined using the FISH (fluorescence in situ hybridisation)-technique. The best yield of intact nuclei was obtained from lymph node tissue. The prevalence rate of KS in males with breast cancer was found to be 7.5 per cent, a much higher rate than previously reported (approximately 3 per cent). Methodological differences are suggested to cause the increased prevalence rate. Based on our finding and on the prevalence of KS in the normal population as well as on the incidence of MBC, a 50-fold increased risk of developing breast cancer in males with KS relative to normal males was found. The same median age at diagnosis, 72 years, was established for both groups of patients. No differences in survival were seen.
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| 4. |
- Weimarck, Torsten, et al.
(author)
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Further reflections on the performative experiences of artefacts for everyday use
- 2010
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In: Det åskådliga och det bottenlösa : tankar kring konst och humaniora tillägnade Margaretha Rossholm Lagerlöf. - 1650-5298. - 9789197631518 ; 22, s. 254-259
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Book chapter (peer-reviewed)abstract
- The article may be seen as a sequel to my paper delivered at a conference on art historical subjectivity and methodology in Stockholm 1999, initiated by Margaretha Rossholm Lagerlöf. – Now I will try to move that analysis a little step further by discussing some problems concerning the more explicit performative effects and experiences of everyday technical objects and their occasionally strange visual expressions in relation to their evident role as handy utility articles or equipment. Performative, because I am especially interested in the effects upon the user or beholder, and how the expressions are transmitted into, and re-used, in an individually experienced universe.
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