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  • Stevens, Marc, 1984-, et al. (author)
  • A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones
  • 2015
  • In: Organic and biomolecular chemistry. - : Royal Society of Chemistry (RSC). - 1477-0520 .- 1477-0539. ; 13:7, s. 2044-2054
  • Journal article (peer-reviewed)abstract
    • A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups.
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