↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Wike J) "

Search: WFRF:(Wike J)

Result 1-3 of 3

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Guo, Jingtao, et al. (author) Chromatin and Single-Cell RNA- Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development 2017 In: Cell Stem Cell. - : CELL PRESS. - 1934-5909 .- 1875-9777. ; 21:4, s. 533-546 Journal article (peer-reviewed)abstract Human adult spermatogonial stem cells (hSSCs) must balance self-renewal and differentiation. To understand how this is achieved, we profiled DNA methylation and open chromatin (ATAC-seq) in SSEA4(+) hSSCs, analyzed bulk and single-cell RNA transcriptomes (RNA-seq) in SSEA4+ hSSCs and differentiating c-KIT+ spermatogonia, and performed validation studies via immunofluorescence. First, DNA hypomethylation at embryonic developmental genes supports their epigenetic "poising'' in hSSCs for future/embryonic expression, while core pluripotency genes (OCT4 and NANOG) were transcriptionally and epigenetically repressed. Interestingly, open chromatin in hSSCs was strikingly enriched in binding sites for pioneer factors (NFYA/B, DMRT1, and hormone receptors). Remarkably, single-cell RNA-seq clustering analysis identified four cellular/developmental states during hSSC differentiation, involving major transitions in cell-cycle and transcriptional regulators, splicing and signaling factors, and glucose/mitochondria regulators. Overall, our results outline the dynamic chromatin/transcription landscape operating in hSSCs and identify crucial molecular pathways that accompany the transition from quiescence to proliferation and differentiation.
2.	Brock, W A, et al. (author) Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer. 1995 In: International journal of radiation oncology, biology, physics. - 0360-3016. ; 32:5, s. 1371-9 Journal article (peer-reviewed)abstract To determine if the radiosensitivity of normal human skin fibroblasts, measured in early passage cultures, is significantly correlated with the degree of acute or late normal skin damage in patients treated for breast cancer with radiotherapy.
3.	Wike, Franziska, et al. (author) Multi-stage reaction history in different eclogite types from the Pakistan Himalaya and implications for exhumation processes 2009 In: Lithos. - : Elsevier BV. - 0024-4937. Journal article (peer-reviewed)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-3 of 3

Refine your search

Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Turesson, I (1); Lindskog, Cecilia (1); Nyman, Jan, 1956 (1); Khan, M. A. (1); Tucker, S L (1); Konrad-Schmolke, Mat ... (1); show more...; Brock, W.A. (1); O'Brien, Patrick J. (1); Geara, F B (1); Wike, J (1); Peters, L J (1); Hotaling, James M. (1); Carrell, Douglas T. (1); Guo, Jingtao (1); Grow, Edward J. (1); Yi, Chongil (1); Mlcochova, Hana (1); Maher, Geoffrey J. (1); Murphy, Patrick J. (1); Wike, Candice L. (1); Goriely, Anne (1); Cairns, Bradley R. (1); Wike, Franziska (1); Altenberger, Uwe (1); show less...

University: University of Gothenburg (2); Uppsala University (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view