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1.	Kapelios, CJ, et al. (author) Sacubitril/valsartan eligibility and outcomes in the ESC-EORP-HFA Heart Failure Long-Term Registry: bridging between European Medicines Agency/Food and Drug Administration label, the PARADIGM-HF trial, ESC guidelines, and real world 2019 In: European journal of heart failure. - : Wiley. - 1879-0844 .- 1388-9842. ; 21:11, s. 1383-1397 Journal article (peer-reviewed)
2.	Orth, M, et al. (author) Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY 2011 In: Journal of neurology, neurosurgery, and psychiatry. - : BMJ. - 1468-330X .- 0022-3050. ; 82:12, s. 1409- Journal article (other academic/artistic)
3.	Jiang, X., et al. (author) Shared heritability and functional enrichment across six solid cancers 2019 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10 Journal article (peer-reviewed)abstract Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
4.	Matejcic, M, et al. (author) Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 382- Journal article (peer-reviewed)abstract The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.
5.	Gusev, A, et al. (author) Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation 2016 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 10979- Journal article (peer-reviewed)abstract Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
6.	Pedersen, TR, et al. (author) Cholesterol lowering and the use of healthcare resources. Results of the Scandinavian Simvastatin Survival Study 1996 In: Circulation. - 0009-7322. ; 93:10, s. 1796-1802 Journal article (peer-reviewed)
7.	Jiang, X, et al. (author) Publisher Correction: Shared heritability and functional enrichment across six solid cancers 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4386- Journal article (other academic/artistic)abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.	Southey, MC, et al. (author) PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS 2016 In: Journal of medical genetics. - : BMJ. - 1468-6244 .- 0022-2593. ; 53:12, s. 800-811 Journal article (peer-reviewed)
9.	Mach, F., et al. (author) 2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk 2019 In: Atherosclerosis. - : Elsevier BV. - 0021-9150. ; 290, s. 140-205 Journal article (peer-reviewed)
10.	Speliotes, Elizabeth K., et al. (author) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 2010 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948 Journal article (peer-reviewed)abstract Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

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Result 1-10 of 561

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Type of publication: journal article (456); conference paper (82); other publication (7); reports (5); book chapter (4); editorial proceedings (2); show more...; research review (2); review (2); book (1); show less...

Type of content: peer-reviewed (432); other academic/artistic (128); pop. science, debate, etc. (1)

Author/Editor: Wiklund, P (249); Wiklund, F (103); Gronberg, H (64); Mottrie, A (51); Kote-Jarai, Z (47); Schleutker, J (41); show more...; Haiman, CA (39); Kibel, AS (38); Eeles, RA (38); Muir, K (37); Sooriakumaran, P (37); Aly, M (36); Travis, RC (36); Maier, C (36); Hosseini, A. (35); Al Olama, AA (35); Berndt, SI (35); Neal, DE (35); Brenner, H (34); Dasgupta, P. (34); Stanford, JL (34); Giles, GG (33); Batra, J (33); Kraft, P (32); Cybulski, C (32); Easton, DF (31); Albanes, D (31); Teixeira, MR (31); Nordestgaard, BG (30); Thibodeau, SN (30); Kaneva, R (30); Mehrazin, R (30); Tewari, A (30); Egevad, L (29); Guru, KA (29); Hunter, DJ (28); Pashayan, N (28); Cannon-Albright, L (28); Park, JY (28); Carlsson, S (27); Henderson, BE (27); Benlloch, S (26); Khaw, KT (26); Le Marchand, L (25); Hamdy, FC (25); John, EM (24); Conti, DV (24); Lindstrom, S (24); Donovan, JL (24); Lantz, A (24); show less...

University: Karolinska Institutet (417); Uppsala University (69); Umeå University (51); University of Gothenburg (46); Lund University (23); Linköping University (8); show more...; Royal Institute of Technology (7); Jönköping University (7); Luleå University of Technology (5); University of Borås (5); RISE (4); Karlstad University (4); Chalmers University of Technology (3); Blekinge Institute of Technology (3); Stockholm University (2); Mälardalen University (2); Mid Sweden University (2); Högskolan Dalarna (2); VTI - The Swedish National Road and Transport Research Institute (2); Örebro University (1); Södertörn University (1); University of Skövde (1); Linnaeus University (1); Marie Cederschiöld högskola (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (556); Swedish (4); Undefined language (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (96); Natural sciences (20); Engineering and Technology (18); Social Sciences (6); Agricultural Sciences (2); Humanities (2)

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