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Search: WFRF:(Wither J)

  • Result 1-4 of 4
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1.
  • Langefeld, Carl D., et al. (author)
  • Transancestral mapping and genetic load in systemic lupus erythematosus
  • 2017
  • In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 8
  • Journal article (peer-reviewed)abstract
    • Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.
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2.
  • Bentham, James, et al. (author)
  • Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
  • 2015
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 47:12, s. 1457-1464
  • Journal article (peer-reviewed)abstract
    • Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous genome-wide association studies (GWAS) had modest sample sizes, reducing their scope and reliability. Our study comprised 7,219 cases and 15,991 controls of European ancestry, constituting a new GWAS, a meta-analysis with a published GWAS and a replication study. We have mapped 43 susceptibility loci, including ten new associations. Assisted by dense genome coverage, imputation provided evidence for missense variants underpinning associations in eight genes. Other likely causal genes were established by examining associated alleles for cis-acting eQTL effects in a range of ex vivo immune cells. We found an over-representation (n = 16) of transcription factors among SLE susceptibility genes. This finding supports the view that aberrantly regulated gene expression networks in multiple cell types in both the innate and adaptive immune response contribute to the risk of developing SLE.
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  • Result 1-4 of 4
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journal article (3)
conference paper (1)
Type of content
peer-reviewed (3)
other academic/artistic (1)
Author/Editor
Alarcón-Riquelme, Ma ... (2)
Martin, Javier (2)
Gabrielsson, S (2)
Rönnblom, Lars (2)
Vyse, Timothy J. (2)
Gunnarsson, Iva (1)
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Svenungsson, Elisabe ... (1)
Scherbarth, Hugo R (1)
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D'Alfonso, Sandra (1)
Baca, Vicente (1)
Orozco, Lorena (1)
Ortego-Centeno, Norb ... (1)
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De Carvalho, D (1)
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Kelly, Jennifer A. (1)
Kaufman, Kenneth M. (1)
Guthridge, Joel M. (1)
Brown, Elizabeth E. (1)
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Reveille, John D. (1)
Vila, Luis M. (1)
Criswell, Lindsey A. (1)
Edberg, Jeffrey C. (1)
Freedman, Barry I. (1)
Gregersen, Peter K. (1)
Gilkeson, Gary S. (1)
Jacob, Chaim O. (1)
James, Judith A. (1)
Kamen, Diane L. (1)
Kimberly, Robert P. (1)
Merrill, Joan T. (1)
Niewold, Timothy B. (1)
Tsao, Betty P. (1)
Langefeld, Carl D. (1)
Harley, John B. (1)
Gaffney, Patrick M. (1)
Frostegard, Johan (1)
Cervera, Ricard (1)
Sjöwall, Christopher (1)
Cardiel, Mario H (1)
Rantapää-Dahlqvist, ... (1)
Petri, Michelle (1)
Gladman, Dafna D. (1)
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Karolinska Institutet (3)
Uppsala University (2)
Umeå University (1)
Linköping University (1)
Lund University (1)
Language
English (4)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

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