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1.	Yasuda, Kazuki, et al. (author) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus 2008 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:9, s. 1092-1097 Journal article (peer-reviewed)abstract We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs2237892 in intron 15 showed the lowest P value (6.7 x 10(-13), odds ratio (OR) = 1.49). The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of beta-cell function or the corrected insulin response. Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries.

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Nilsson, Peter (1); Lyssenko, Valeriya (1); Tuomi, Tiinamaija (1); Groop, Leif (1); Nakamura, Yusuke (1); Jonsson, Anna (1); show more...; Ma, Ronald C W (1); Seino, Yutaka (1); Yamada, Yuichiro (1); Kadowaki, Takashi (1); Chan, Juliana C N (1); So, Wing-Yee (1); Yamamoto, Ken (1); Hara, Kazuo (1); Cho, Young Min (1); Park, Kyong Soo (1); Kamatani, Naoyuki (1); Ng, Maggie C. Y. (1); Shin, Hyoung Doo (1); Yoshida, Teruhiko (1); Lee, Hong Kyu (1); Tokunaga, Katsushi (1); Maegawa, Hiroshi (1); Yasuda, Kazuki (1); Miyake, Kazuaki (1); Horikawa, Yukio (1); Osawa, Haruhiko (1); Furuta, Hiroto (1); Hirota, Yushi (1); Mori, Hiroyuki (1); Sato, Yoshifumi (1); Yamagata, Kazuya (1); Hinokio, Yoshinori (1); Wang, He-Yao (1); Tanahashi, Toshihito (1); Nakamura, Naoto (1); Oka, Yoshitomo (1); Iwasaki, Naoko (1); Iwamoto, Yasuhiko (1); Kashiwagi, Atsunori (1); Takeda, Jun (1); Maeda, Eiichi (1); Sekine, Akihiro (1); Itakura, Mitsuo (1); Makino, Hideichi (1); Nanjo, Kishio (1); Kasuga, Masato (1); show less...

University: Lund University (1)

Language: English (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2008 (1)

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