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Träfflista för sökning "WFRF:(Yasue A) "

Search: WFRF:(Yasue A)

  • Result 1-3 of 3
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  • Du, QQ, et al. (author)
  • Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo
  • 2022
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:40, s. e2203307119-
  • Journal article (peer-reviewed)abstract
    • Brown adipose tissue (BAT) is a highly specialized adipose tissue in its immobile location and size during the entire adulthood. In response to cold exposure and other β3-adrenoreceptor stimuli, BAT commits energy consumption by nonshivering thermogenesis (NST). However, the molecular machinery in controlling the BAT mass in adults is unknown. Here, we show our surprising findings that the BAT mass and functions can be manipulated in adult animals by controlling BAT adipocyte differentiation in vivo. Platelet-derived growth factor receptor α (PDGFα) expressed in BAT progenitor cells served a signaling function to avert adipose progenitor differentiation. Genetic and pharmacological loss-of-function of PDGFRα eliminated the differentiation barrier and permitted progenitor cell differentiation to mature and functional BAT adipocytes. Consequently, an enlarged BAT mass (megaBAT) was created by PDGFRα inhibition owing to increases of brown adipocyte numbers. Under cold exposure, a microRNA-485 (miR-485) was identified as a master suppressor of the PDGFRα signaling, and delivery of miR-485 also produced megaBAT in adult animals. Noticeably, megaBAT markedly improved global metabolism, insulin sensitivity, high-fat-diet (HFD)-induced obesity, and diabetes by enhancing NST. Together, our findings demonstrate that the adult BAT mass can be increased by blocking the previously unprecedented inhibitory signaling for BAT progenitor cell differentiation. Thus, blocking the PDGFRα for the generation of megaBAT provides an attractive strategy for treating obesity and type 2 diabetes mellitus (T2DM).
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3.
  • Fischer, C, et al. (author)
  • A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning
  • 2017
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1, s. 2079-
  • Journal article (peer-reviewed)abstract
    • Understanding the molecular mechanisms regulating beige adipocyte formation may lead to the development of new therapies to combat obesity. Here, we report a miRNA-based autocrine regulatory pathway that controls differentiation of preadipocytes into beige adipocytes. We identify miR-327 as one of the most downregulated miRNAs targeting growth factors in the stromal-vascular fraction (SVF) under conditions that promote white adipose tissue (WAT) browning in mice. Gain- and loss-of-function experiments reveal that miR-327 targets FGF10 to prevent beige adipocyte differentiation. Pharmacological and physiological β-adrenergic stimulation upregulates FGF10 levels and promotes preadipocyte differentiation into beige adipocytes. In vivo local delivery of miR-327 to WATs significantly compromises the beige phenotype and thermogenesis. Contrarily, systemic inhibition of miR-327 in mice induces browning and increases whole-body metabolic rate under thermoneutral conditions. Our data provide mechanistic insight into an autocrine regulatory signaling loop that regulates beige adipocyte formation and suggests that the miR-327–FGF10–FGFR2 signaling axis may be a therapeutic targets for treatment of obesity and metabolic diseases.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Fischer, C. (3)
Miyake, M (3)
Seki, T (3)
Yasue, A (3)
Oyadomari, S (3)
Gao, J. (2)
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Tong, L (2)
Cao, YH (2)
Yang, YL (2)
Hosaka, K (2)
Tao, W (2)
Jing, X (2)
Sobajima, M (2)
Sun, X. (1)
Yang, Y. (1)
Zhang, J. (1)
Zhang, Y. (1)
Cao, Y (1)
Du, Q. (1)
Zhou, Q. (1)
Wang, YG (1)
Andersson, P (1)
Chen, F (1)
Wu, J (1)
He, X (1)
Nakamura, M. (1)
Li, XR (1)
Samani, NJ (1)
Lim, S (1)
Yao, S (1)
He, XK (1)
Ge, M. (1)
Wu, JY (1)
Honek, J (1)
Zhou, QJ (1)
Du, QQ (1)
Yao, SZ (1)
Sun, XT (1)
Ge, MH (1)
Gao, YY (1)
Liu, YZ (1)
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University
Karolinska Institutet (3)
Language
English (3)

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