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- Andersson, U, et al.
(författare)
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HMGB1 is a therapeutic target for sterile inflammation and infection
- 2011
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Ingår i: Annual review of immunology. - : Annual Reviews. - 1545-3278 .- 0732-0582. ; 29, s. 139-162
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Tidskriftsartikel (refereegranskat)abstract
- A key question in immunology concerns how sterile injury activates innate immunity to mediate damaging inflammation in the absence of foreign invaders. The discovery that HMGB1, a ubiquitous nuclear protein, mediates the activation of innate immune responses led directly to the understanding that HMGB1 plays a critical role at the intersection of the host inflammatory response to sterile and infectious threat. HMGB1 is actively released by stimulation of the innate immune system with exogenous pathogen-derived molecules and is passively released by ischemia or cell injury in the absence of invasion. Established molecular mechanisms of HMGB1 binding and signaling through TLR4 reveal signaling pathways that mediate cytokine release and tissue damage. Experimental strategies that selectively target HMGB1 and TLR4 effectively reverse and prevent activation of innate immunity and significantly attenuate damage in diverse models of sterile and infection-induced threat.
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- Davis, MM, et al.
(författare)
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Rebooting Human Immunology
- 2018
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Ingår i: Annual review of immunology. - : Annual Reviews. - 1545-3278 .- 0732-0582. ; 36, s. 843-864
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Tidskriftsartikel (refereegranskat)abstract
- Recent progress in both conceptual and technological approaches to human immunology have rejuvenated a field that has long been in the shadow of the inbred mouse model. This is a healthy development both for the clinical relevance of immunology and for the fact that it is a way to gain access to the wealth of phenomenology in the many human diseases that involve the immune system. This is where we are likely to discover new immunological mechanisms and principals, especially those involving genetic heterogeneity or environmental influences that are difficult to model effectively in inbred mice. We also suggest that there are likely to be novel immunological mechanisms in long-lived, less fecund mammals such as human beings since they must remain healthy far longer than short-lived rodents in order for the species to survive.
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