SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Yung Christina K.) "

Search: WFRF:(Yung Christina K.)

  • Result 1-4 of 4
Sort/group result
   
EnumerationReferenceCoverFind
1.
  •  
2.
  • Hudson, Thomas J., et al. (author)
  • International network of cancer genome projects
  • 2010
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
  • Journal article (peer-reviewed)abstract
    • The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
  •  
3.
  • Weinstein, John N., et al. (author)
  • The cancer genome atlas pan-cancer analysis project
  • 2013
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:10, s. 1113-1120
  • Journal article (peer-reviewed)abstract
    • The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
  •  
4.
  • Zaidi, Syed H., et al. (author)
  • Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
  • 2020
  • In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 11:1
  • Journal article (peer-reviewed)abstract
    • Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge of CRC. We identify PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional genes significantly mutated in CRC. We find that among hypermutated tumors, an increased mutation burden is associated with improved CRC-specific survival (HR=0.42, 95% CI: 0.21-0.82). Mutations in TP53 are associated with poorer CRC-specific survival, which is most pronounced in cases carrying TP53 mutations with predicted 0% transcriptional activity (HR=1.53, 95% CI: 1.21-1.94). Furthermore, we observe differences in mutational frequency of several genes and pathways by tumor location, stage, and sex. Overall, this large study provides deep insights into somatic mutations in CRC, and their potential relationships with survival and tumor features. Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutational burden and specific mutations in TP53 are associated with survival odds.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-4 of 4
Type of publication
journal article (4)
Type of content
peer-reviewed (4)
Author/Editor
Zhang, Yan (1)
Yang, Yang (1)
Korhonen, Laura (1)
Lindholm, Dan (1)
Pontén, Fredrik (1)
Vertessy, Beata G. (1)
show more...
Chang-Claude, Jenny (1)
Wang, Mei (1)
Uhlén, Mathias (1)
Campo, Elias (1)
Wang, Xin (1)
Liu, Yang (1)
Jörnsten, Rebecka, 1 ... (1)
Kumar, Rakesh (1)
Wang, Dong (1)
Kling, Teresia, 1985 (1)
Sánchez, José, 1979 (1)
Nelander, Sven, 1974 (1)
Li, Ke (1)
Liu, Ke (1)
Zhang, Yang (1)
Nettekoven, Gerd (1)
Nàgy, Péter (1)
Bardelli, Alberto (1)
Caldas, Carlos (1)
Calvo, Fabien (1)
Kominami, Eiki (1)
van der Goot, F. Gis ... (1)
Bonaldo, Paolo (1)
Egevad, Lars (1)
Thum, Thomas (1)
Berndt, Sonja I (1)
Chanock, Stephen J (1)
Brenner, Hermann (1)
Thibodeau, Stephen N (1)
Adams, Christopher M (1)
Estivill, Xavier (1)
Flicek, Paul (1)
Guigo, Roderic (1)
Gut, Ivo (1)
Lehrach, Hans (1)
Minucci, Saverio (1)
Stunnenberg, Hendrik ... (1)
Valencia, Alfonso (1)
Vellenga, Edo (1)
Swärd, Karl (1)
Wainwright, Brandon ... (1)
Nilsson, Per (1)
De Milito, Angelo (1)
Zhang, Wei (1)
show less...
University
Umeå University (2)
Lund University (2)
Karolinska Institutet (2)
University of Gothenburg (1)
Royal Institute of Technology (1)
Uppsala University (1)
show more...
Stockholm University (1)
Linköping University (1)
Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
show less...
Language
English (4)
Research subject (UKÄ/SCB)
Medical and Health Sciences (4)
Natural sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view