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  • Zamolodchikov, D, et al. (author)
  • Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma
  • 2015
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 112:13, s. 4068-4073
  • Journal article (peer-reviewed)abstract
    • Alzheimer’s disease (AD) is a growing public health problem, in part because there are no effective therapies. Major roadblocks to the treatment of AD are the lack of adequate diagnostic tools and the absence of viable therapeutic targets. It is now clear that AD is characterized by inflammation. Our results indicate that AD patients and mouse models have increased activation of a set of proteins known as the contact activation system in their circulation. We also demonstrate that the AD-related peptide Aβ can initiate activation of this system in the circulation of animal models. Because the contact activation system contributes to inflammation, our results suggest new pathogenic mechanisms, diagnostic tests, and therapeutic targets for AD.
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  • Result 1-3 of 3
Type of publication
journal article (2)
conference paper (1)
Type of content
peer-reviewed (2)
other academic/artistic (1)
Author/Editor
Zamolodchikov, D (3)
Renne, T (2)
Strickland, S (2)
aut (1)
University
Karolinska Institutet (3)
Language
English (3)

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