| 1. |
- Zhang, Yunqiu, et al.
(author)
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Nanomanganese cobaltate-decorated halloysite nanotubes for the complete degradation of ornidazole via peroxymonosulfate activation
- 2023
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In: Journal of Colloid and Interface Science. - : Elsevier. - 0021-9797 .- 1095-7103. ; 630, s. 855-866
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Journal article (peer-reviewed)abstract
- Peroxymonosulfate (PMS) driven by halloysite nanotubes (HNTs) modified with nanomanganese cobaltate (MnCo2O4) generates reactive oxygen species (ROS) that offer high degradation efficiency and mineralization rates for many typical antibiotic pollutants, such as ornidazole (ONZ). The experimental results show that halloysite nanotubes (HNTs) modified with nanomanganese cobaltate (MnCo2O4@HNTs denoted as MCO@HNTs) can degrade ONZ completely over a wide pH range (6.08–11.00) with little influence of the pH value. MCO@HNTs + PMS exhibited higher catalytic activity and lower Co- and Mn-ion leaching rates. It also showed a strong anti-interference effect on natural lake water and anions. Additionally, PMS can be quickly activated and consumed in natural lakes to avoid secondary pollution. The roasting of MCO@HNTs showed good catalytic activity and stability after degrading ONZ. The combination of ion quenching and electron paramagnetic resonance (EPR) analysis illustrated that the MCO@HNTs + PMS system had a strong oxidation capacity, and the produced singlet oxygen (1O2) was the main ROS for ONZ degradation. The degradation pathway of ONZ via the MCO@HNTs + PMS system was proposed based on the types of intermediates determined via liquid chromatography-mass spectrometry (LC-MS). This comprehensive study shows the preparation of a simple, environmentally friendly, and cheap PMS activation catalyst that has practical application value in the treatment of antibiotic wastewater and provides a focus on actual water testing with residual amount of PMS.
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| 2. |
- Jia, Xiuxiu, et al.
(author)
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Mesopore-rich badam-shell biochar for efficient adsorption of Cr(VI) from aqueous solution
- 2021
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In: Journal of Environmental Chemical Engineering. - : Elsevier. - 2213-3437. ; 9:4
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Journal article (peer-reviewed)abstract
- Cr(VI) is a common pollutant in wastewater and many previous studies using biochar-based materials as adsorbents for their well adsorption performance. However, the preparations of some biochars are complex, uneconomical, and with a poor reusability, which set limit on their practical application. Here, a mesoporous-rich biochar-based Cr(VI) adsorbent was easily prepared by pyrolyzing the badam-shell that in situ activated by concentrated phosphoric acid (H3PO4), with the aim of improving the removal effect of Cr(VI) in an aqueous solution. The partition coefficient (PC) was used to compare the performance of adsorbents more comprehensively, and the maximal PC value of the activated badam-shell biochar (ABSB) was 978.8 L g-1. In addition, its maximum adsorption capacity was 276.6 mg g-1. ABSB has a superior removal effect on the relatively low concentration of Cr(VI) (= 50 mg L-1), and residual Cr(VI) can meet the maximum emission standard (< 0.5 mg L-1) of industrial wastewater. The specific surface area of ABSB (1359.5 m2 g-1) was approximately four times that of pristine badam-shell biochar (BSB) (371.87 m2 g-1). The adsorption mechanisms involved were redox, complexation, electrostatic attraction and hydrogen bonding. The removal rate of Cr(VI) on ABSB remained at 81.6% after six cycles of adsorption-desorption. In a word, our study provides a simple, economic, and environmental method in fabricating the new adsorbent, which is highly promising and will not cause secondary pollution.
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| 3. |
- Li, Jiuyi, et al.
(author)
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Individual Assignment of Adult Diffuse Gliomas into the EM/PM Molecular Subtypes Using a TaqMan Low-Density Array.
- 2019
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In: Clinical cancer research : an official journal of the American Association for Cancer Research. - 1078-0432. ; 25:23, s. 7068-7077
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Journal article (peer-reviewed)abstract
- We aimed to develop a diagnostic platform to capture the transcriptomic resemblance of individual adult diffuse gliomas of WHO grades II-IV to neural development and the genomic signature associated with glioma progression.Based on the EM/PM classification scheme, we designed a RT-PCR-based TaqMan Low-density array (TLDA) containing 44 classifier and 4 reference genes. Samples of a training data set (GSE48865), characterized by RNA-sequencing, were utilized to optimize the TLDA design and to develop a support vector machine (SVM)-based prediction model. Complemented with Sanger sequencing for IDH1/2, and low coverage whole genome sequencing (WGS), the TLDA and SVM prediction model were tested in a validation (31 gliomas) and a test (121 gliomas) dataset.Independent of morphologically defined subtypes and grades, gliomas can be individually assigned into the EM and PM glioma subtypes with the respective areas under ROC curves at 0.86 and 0.85 in the validation dataset. The EM gliomas showed a medium overall survival (OS) of 15.6 months, whereas the medium OS for PM gliomas was not reached (hazard ratio = 3.55, 95% confidence interval: 1.96 to 6.45). The EM and PM gliomas showed distinct patterns of genomic alterations, with IDH mutation and 1p19q co-deletion in the PM gliomas and gain of chromosome 7/loss of chromosome 10 in the EM gliomas. Extensive chromosomal abnormalities marked the progression of PM gliomas.The integration of EM/PM subtyping, IDH sequencing and low coverage WGS may improve the risk stratification and selection of treatment regimens for glioma patients.
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| 4. |
- Wei, Yanfei, et al.
(author)
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Stalled oligodendrocyte differentiation in IDH-mutant gliomas.
- 2023
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In: Genome medicine. - 1756-994X. ; 15:1
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Journal article (peer-reviewed)abstract
- Roughly 50% of adult gliomas harbor isocitrate dehydrogenase (IDH) mutations. According to the 2021 WHO classification guideline, these gliomas are diagnosed as astrocytomas, harboring no 1p19q co-deletion, or oligodendrogliomas, harboring 1p19q co-deletion. Recent studies report that IDH-mutant gliomas share a common developmental hierarchy. However, the neural lineages and differentiation stages in IDH-mutant gliomas remain inadequately characterized.Using bulk transcriptomes and single-cell transcriptomes, we identified genes enriched in IDH-mutant gliomas with or without 1p19q co-deletion, we also assessed the expression pattern of stage-specific signatures and key regulators of oligodendrocyte lineage differentiation. We compared the expression of oligodendrocyte lineage stage-specific markers between quiescent and proliferating malignant single cells. The gene expression profiles were validated using RNAscope analysis and myelin staining and were further substantiated using data of DNA methylation and single-cell ATAC-seq. As a control, we assessed the expression pattern of astrocyte lineage markers.Genes concordantly enriched in both subtypes of IDH-mutant gliomas are upregulated in oligodendrocyte progenitor cells (OPC). Signatures of early stages of oligodendrocyte lineage and key regulators of OPC specification and maintenance are enriched in all IDH-mutant gliomas. In contrast, signature of myelin-forming oligodendrocytes, myelination regulators, and myelin components are significantly down-regulated or absent in IDH-mutant gliomas. Further, single-cell transcriptomes of IDH-mutant gliomas are similar to OPC and differentiation-committed oligodendrocyte progenitors, but not to myelinating oligodendrocyte. Most IDH-mutant glioma cells are quiescent; quiescent cells and proliferating cells resemble the same differentiation stage of oligodendrocyte lineage. Mirroring the gene expression profiles along the oligodendrocyte lineage, analyses of DNA methylation and single-cell ATAC-seq data demonstrate that genes of myelination regulators and myelin components are hypermethylated and show inaccessible chromatin status, whereas regulators of OPC specification and maintenance are hypomethylated and show open chromatin status. Markers of astrocyte precursors are not enriched in IDH-mutant gliomas.Our studies show that despite differences in clinical manifestation and genomic alterations, all IDH-mutant gliomas resemble early stages of oligodendrocyte lineage and are stalled in oligodendrocyte differentiation due to blocked myelination program. These findings provide a framework to accommodate biological features and therapy development for IDH-mutant gliomas.
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| 5. |
- Hao, Chenglin, et al.
(author)
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Low-temperature molten-salt synthesis of Co3O4 nanoparticles grown on MXene can rapidly remove ornidazole via peroxymonosulfate activation
- 2023
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In: Environmental Pollution. - : Elsevier. - 0269-7491 .- 1873-6424. ; 334
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Journal article (peer-reviewed)abstract
- We further developed previous work on MXene materials prepared using molten salt methodology. We substituted single, with mixed salts, and reduced the melting point from >724 °C to <360 °C. Cobalt (Co) compounds were simultaneously etched and doped while the MXene material was created using various techniques in which Co compounds occur as Co3O4. The synthesized Co3O4/MXene compound was used as a peroxymonosulfate (PMS) activator that would generate free radicals to degrade antibiotic ornidazole (ONZ). Under optimal conditions, almost 100% of ONZ (30 mg/L) was degraded within 10 min. The Co3O4/MXene + PMS system efficiently degraded ONZ in natural water bodies, and had a broad pH adaptation range (4–11), and strong anion anti-interference. We investigated how the four active substances were generated using radical quenching and electron paramagnetic resonance (EPR) spectroscopy. We identified 12 ONZ intermediates by liquid chromatography-mass spectrometry and propose a plausible degradative mechanism.
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| 6. |
- He, Zhuang, et al.
(author)
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Microwave-assisted synthesis of amorphous cobalt nanoparticle decorated N-doped biochar for highly efficient degradation of sulfamethazine via peroxymonosulfate activation
- 2022
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In: Journal of Water Process Engineering. - : Elsevier. - 2214-7144. ; 50
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Journal article (peer-reviewed)abstract
- In the present work, a microwave-assisted and secondary roasting preparation process was used to synthesize nanocomposite materials. These materials were modified with amorphous cobalt nanoparticles (Co NPs) on the surface of biochar doped with different nitrogen sources (melamine (Me), 1,10-phenanthroline (Ph), and urea (Ur)). The nanocomposite (Co-N-C(Ur)) with urea as the nitrogen source promoted the generation of mesopores on the surface of carbon materials due to its evaporation during the preparation process thus enhancing the attachment sites of cobalt nanoparticles. The Co-N-C(Ur) had a more significant degradation effect on the primary carcinogen sulfamethazine (SMT) by activating peroxymonosulfate (PMS). The degradation rate of SMT pollutants was 96.6 % within 30 min. The optimal reaction conditions were as follows: catalyst dosage of 0.4 g L−1, PMS dosage of 0.812 mM, SMT concentration of 10 mg L−1, and pH of 5.67. Additionally, the Co-N-C(Ur) catalysts possess excellent specific surface area due to the evaporation effect of the calcination process of urea itself compared to other nitrogen source doping. Electrochemical tests revealed that the composites prepared with urea as the nitrogen source had higher PMS-induced current density and lowered material impedance values, which effectively promoted the catalytic performance of SMT degradation. Concurrently, the Co-N-C (Ur) + PMS reaction system exhibited excellent catalytic performance against other antibiotic organic pollutants. Subsequently, through the capture experiments and electron paramagnetic resonance technical analyses, it was determined that the singlet 1O2 played a leading role in the reaction system. Finally, a thorough liquid chromatography-mass spectrometry analysis suggested the possible SMT degradation pathways, thereby providing a new strategy for the subsequent heterogeneous catalysts to degrade persistent organic pollutants.
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