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Träfflista för sökning "WFRF:(Zhao Guanghong) "

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1.	Huang, Hongyun, et al. (author) Beijing declaration of International Association of Neurorestoratology (2023 Xi'an version) 2023 In: Journal of Neurorestoratology. - : Elsevier. - 2324-2426. ; 11:2 Journal article (other academic/artistic)
2.	Li, Qishuang, et al. (author) Identification of the cytochrome P450s responsible for the biosynthesis of two types of aporphine alkaloids and their de novo biosynthesis in yeast 2024 In: Journal of Integrative Plant Biology. - 1672-9072 .- 1744-7909. ; In Press Journal article (peer-reviewed)abstract Aporphine alkaloids have diverse pharmacological activities; however, our understanding of their biosynthesis is relatively limited. Previous studies have classified aporphine alkaloids into two categories based on the configuration and number of substituents of the D-ring and have proposed preliminary biosynthetic pathways for each category. In this study, we identified two specific cytochrome P450 enzymes (CYP80G6 and CYP80Q5) with distinct activities toward (S)-configured and (R)-configured substrates from the herbaceous perennial vine Stephania tetrandra, shedding light on the biosynthetic mechanisms and stereochemical features of these two aporphine alkaloid categories. Additionally, we characterized two CYP719C enzymes (CYP719C3 and CYP719C4) that catalyzed the formation of the methylenedioxy bridge, an essential pharmacophoric group, on the A- and D-rings, respectively, of aporphine alkaloids. Leveraging the functional characterization of these crucial cytochrome P450 enzymes, we reconstructed the biosynthetic pathways for the two types of aporphine alkaloids in budding yeast (Saccharomyces cerevisiae) for the de novo production of compounds such as (R)-glaziovine, (S)-glaziovine, and magnoflorine. This study provides key insight into the biosynthesis of aporphine alkaloids and lays a foundation for producing these valuable compounds through synthetic biology.
3.	Xu, Yingying, et al. (author) Improved cardiac performance by rosuvastatin is associated with attenuations in both myocardial tumor necrosis factor-alpha and p38 MAP kinase activity in rats after myocardial infarction. 2010 In: The American journal of the medical sciences. - 1538-2990. ; 340:2, s. 121-7 Journal article (peer-reviewed)abstract Statins have been shown to exert anti-inflammatory effects. The aim of this study was to investigate whether rosuvastatin has favorable effect on ventricular remodeling after myocardial infarction (MI), whether this effect is associated with tumor necrosis factor (TNF)-alpha expression and p38 mitogen-activated protein (MAP) kinase pathway and, furthermore, whether there is close correlation between gene expression of TNF-alpha and activity of p38 MAP kinase.

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Type of publication: journal article (3)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Wang, Dong (1); Chen, Yong (1); Chen, Yun, 1978 (1); Fu, Michael, 1963 (1); Kuźma-Kozakiewicz, M ... (1); Chen, Lin (1); show more...; Chen, Xu (1); Wang, Jian (1); Zhang, Yifeng (1); Liu, Jing (1); Sharma, Hari Shanker (1); Zhao, Jianhua (1); Yang, Jian (1); Bryukhovetskiy, Andr ... (1); Li, Qishuang (1); Ma, Ying (1); Jiao, Xiang, 1990 (1); Chen, Tong (1); Cui, Guanghong (1); Tang, Jinfu (1); Guo, Juan (1); Huang, Luqi (1); Cheng, Xiang (1); Li, Xinyi (1); Huang, Hongyun (1); Ao, Qiang (1); Feng, Shiqing (1); Sharma, Alok (1); Liao, Yuhua (1); Wu, Ping (1); Xu, Yingying (1); Saberi, Hooshang (1); Mao, Gengsheng (1); Sanberg, Paul R. (1); Dimitrijevic, Milan (1); Shetty, Ashok K. (1); Al-Zoubi, Ziad M. (1); Chopp, Michael (1); Young, Wise (1); Moviglia, Gustavo (1); Sarnowska, Anna (1); He, Xijing (1); Muresanu, Dafin F. (1); Jeon, Sang Ryong (1); Cho, Kyoung-Suok (1); Alvarez, Edgardo O. (1); Kuffler, Damien (1); Otom, Ali (1); Herrera-Marschitz, M ... (1); Moniche, Francisco (1); show less...

University: University of Gothenburg (1); Uppsala University (1); Chalmers University of Technology (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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