| 1. |
- Cao, Yanhui, et al.
(author)
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A Composite Corrosion Inhibitor of MgAl Layered Double Hydroxides Co-Intercalated with Hydroxide and Organic Anions for Carbon Steel in Simulated Carbonated Concrete Pore Solutions
- 2019
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In: Journal of the Electrochemical Society. - : ELECTROCHEMICAL SOC INC. - 0013-4651 .- 1945-7111. ; 166:11, s. C3106-C3113
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Journal article (peer-reviewed)abstract
- Corrosion of steel in concrete has resulted in shorter service life of concrete constructions and it may also cause serious safety accident. Chloride attack and carbonation of the concrete are two of the most crucial trigger factors for the initiation of corrosion. In order to protect the reinforced steel in concrete from corrosion, in this work, a composite inhibitor of layered double hydroxides (LDHs) intercalated with organic phthalates (PTL) and hydroxide ions (MgAl-LDHs-OH-PTL) were synthesized by calcination-reconstruction methods in ambient atmosphere. The structure, composition and morphology of the prepared MgAl-LDHs-OH-PTL were obtained by X-ray diffraction, Fourier transform infrared spectroscopy and Scanning Electron Microscopy, respectively. The electrochemical measurements indicated that the inhibition efficiency of MgAl-LDHs-OH-PTL for carbon steel in the simulated carbonated concrete pore (SCCP) solutions reached more than 90% when its concentration was 20 g/L. It was found that the MgAl-LDHs-OH-PTL possessed multifunctional protection roles for the carbon steel in concrete, which mainly included decrease of aggressive Cl-ions, increase of the pH of SCCP solutions and release of PTL anions to the solution gradually. The work indicated the promising potential of LDHs compounds as effective multifunctional inhibitors in the field of corrosion protection of reinforced concrete.
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| 2. |
- Cao, Yanhui, et al.
(author)
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Insight into the Fabrication of ZnAl Layered Double Hydroxides Intercalated with Organic Anions and Their Corrosion Protection of Steel Reinforced Concrete
- 2019
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In: Journal of the Electrochemical Society. - : Electrochemical Society. - 0013-4651 .- 1945-7111. ; 166:16, s. C617-C623
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Journal article (peer-reviewed)abstract
- This work provides insight into the fabrication of ZnAl layered double hydroxides (LDHs) intercalated with organic phthalates (PTL) and their corrosion protection of steel reinforced concrete. The structure, composition and morphology of the LDH products prepared by various methods were systematically characterized to find out the relationship of preparation-structure-properties. The ZnAl-LDH-PTL prepared by co-precipitation method presented the best performance of corrosion protection due to its good crystallinity. The corrosion protection mechanism of LDH for steel in concrete system was also discussed.
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| 3. |
- Cao, Yanhui, et al.
(author)
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Layered double hydroxide (LDH) for multi-functionalized corrosion protection of metals : A review
- 2022
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In: Journal of Materials Science & Technology. - : Elsevier BV. - 1005-0302. ; 102, s. 232-263
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Research review (peer-reviewed)abstract
- Layered double hydroxide (LDH) has been widely developed in the field of corrosion and protection in recent years based on its unique characteristics including anion capacity, anion exchange ability, structure memory effect, and barrier resistance. This paper comprehensively reviews recent work on the preparations, properties of LDH in the forms of powder and film and their applications in different environments in corrosion and protection. Some novel perspectives are also proposed at the end of the review for future research in corrosion and protection field.
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| 4. |
- Justice, Anne E., et al.
(author)
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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
- 2019
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:3, s. 452-469
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Journal article (peer-reviewed)abstract
- Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF >= 5%) and nine low-frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
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| 5. |
- Marouli, Eirini, et al.
(author)
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Rare and low-frequency coding variants alter human adult height
- 2017
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 542:7640, s. 186-190
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Journal article (peer-reviewed)abstract
- Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
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