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Träfflista för sökning "WFRF:(Zreik Safa Mayada) "

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  • Ekegren, Jenny K, et al. (author)
  • A new class of HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold
  • 2005
  • In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 48:25, s. 8098-8102
  • Journal article (peer-reviewed)abstract
    • Novel HIV-1 protease inhibitors encompassing a tertiary alcohol as part of the transition-state mimicking unit have been synthesized. Variation of the P1‘−P3‘ residues and alteration of the tertiary alcohol absolute stereochemistry afforded 10 inhibitors. High potencies for the compounds with (S)-configuration at the carbon carrying the tertiary hydroxyl group were achieved with Ki values down to 2.4 nM. X-ray crystallographic data for a representative compound in complex with HIV-1 protease are presented.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Hallberg, Anders (2)
Samuelsson, Bertil (2)
Wallberg, Hans (2)
Unge, Torsten (2)
Ekegren, Jenny (1)
Zreik Safa, Mayada (1)
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Ekegren, Jenny K (1)
Safa, Mayada Zreik (1)
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University
Uppsala University (2)
Language
English (1)
Undefined language (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2005 (2)

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