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- Spartà, R., et al.
(author)
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8B reaction dynamics researched at HIE-ISOLDE
- 2024
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In: Nuovo Cimento della Societa Italiana di Fisica C. - 2037-4909 .- 1826-9885. ; 47:2
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Journal article (peer-reviewed)abstract
- For the first time a measurement of 8B + 64Zn reaction has been performed at HIE-ISOLDE at CERN at energies around the Coulomb barrier, to understand how the debated halo structure of the light nucleus can affect reaction dynamics.
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| 4. |
- Simon, Daniel, 1978-, et al.
(author)
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Admittance spectroscopy of polymer-nanoparticle non-volatile memory devices
- 2006
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In: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 89, s. 133510-
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Journal article (peer-reviewed)abstract
- Nonvolatile resistive memory consisting of gold nanoparticles embedded in the conducting polymer poly(4-n-hexylphenyldiphenylamine) examined using admittance spectroscopy. The frequency dependence of the devices indicates space-charge-limited transport in the high-conductivity "on" state, as well as evidence for similar transport in the lower-conductivity "off" state. Furthermore, the larger dc capacitance of the on state indicates that a greater amount of filling of the midgap nanoparticle trap levels increases the overall device conductivity, leading to the memory effect.
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| 5. |
- Wang, Page I., et al.
(author)
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Sonographically Guided Lumbar Puncture in Pediatric Patients
- 2013
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In: Journal of Ultrasound in Medicine. - : Wiley. - 1550-9613 .- 0278-4297. ; 32:12, s. 2191-2197
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Journal article (peer-reviewed)abstract
- Our aim with this study was to develop a user-friendly method for pediatric sonographically guided lumbar punctures so that we can visualize intrathecal anatomy, confirm intrathecal injection at the time of injection, and, most importantly, avoid ionizing radiation to a child's already radiosensitive pelvis. Sonographically guided lumbar puncture was prospectively performed in children aged 7 weeks to 16 years. All attempts (n = 9) were successful. We were able to identify relevant anatomy (including the conus in children 10 years and younger), confirm intrathecal injection, visualize intrathecal hematoma, and avoid radiation. Sonography is a promising modality for image-guided lumbar punctures without radiation in children.
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- Brusaferri, Ludovica, et al.
(author)
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Neuroimmune activation and increased brain aging in chronic pain patients after the COVID-19 pandemic onset
- 2024
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In: Brain, Behavior, and Immunity. - 0889-1591 .- 1090-2139. ; 116, s. 259-266
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Journal article (peer-reviewed)abstract
- The COVID-19 pandemic has exerted a global impact on both physical and mental health, and clinical populations have been disproportionally affected. To date, however, the mechanisms underlying the deleterious effects of the pandemic on pre-existing clinical conditions remain unclear. Here we investigated whether the onset of the pandemic was associated with an increase in brain/blood levels of inflammatory markers and MRI-estimated brain age in patients with chronic low back pain (cLBP), irrespective of their infection history. A retrospective cohort study was conducted on 56 adult participants with cLBP (28 ‘Pre-Pandemic’, 28 ‘Pandemic’) using integrated Positron Emission Tomography/ Magnetic Resonance Imaging (PET/MRI) and the radioligand [11C]PBR28, which binds to the neuroinflammatory marker 18 kDa Translocator Protein (TSPO). Image data were collected between November 2017 and January 2020 (‘Pre-Pandemic’ cLBP) or between August 2020 and May 2022 (‘Pandemic’ cLBP). Compared to the Pre-Pandemic group, the Pandemic patients demonstrated widespread and statistically significant elevations in brain TSPO levels (P =.05, cluster corrected). PET signal elevations in the Pandemic group were also observed when 1) excluding 3 Pandemic subjects with a known history of COVID infection, or 2) using secondary outcome measures (volume of distribution -VT- and VT ratio - DVR) in a smaller subset of participants. Pandemic subjects also exhibited elevated serum levels of inflammatory markers (IL-16; P <.05) and estimated BA (P <.0001), which were positively correlated with [11C]PBR28 SUVR (r's ≥ 0.35; P's < 0.05). The pain interference scores, which were elevated in the Pandemic group (P <.05), were negatively correlated with [11C]PBR28 SUVR in the amygdala (r = −0.46; P<.05). This work suggests that the pandemic outbreak may have been accompanied by neuroinflammation and increased brain age in cLBP patients, as measured by multimodal imaging and serum testing. This study underscores the broad impact of the pandemic on human health, which extends beyond the morbidity solely mediated by the virus itself.
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