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- d'Alessandro, Elisa, et al.
(author)
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Thrombo-Inflammation in Cardiovascular Disease : An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis
- 2020
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In: Thrombosis and Haemostasis. - : Georg Thieme Verlag KG. - 0340-6245 .- 2567-689X. ; 120:4, s. 538-564
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Journal article (peer-reviewed)abstract
- Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.
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- Sommer, IE, et al.
(author)
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The clinical course of schizophrenia in women and men-a nation-wide cohort study
- 2020
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In: NPJ schizophrenia. - : Springer Science and Business Media LLC. - 2334-265X. ; 6:1, s. 12-
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Journal article (peer-reviewed)abstract
- Gender differences in schizophrenia have been reported in different aspect of the course of disease and may urge special clinical interventions for female patients. Current literature provides insufficient information to design guidelines for treating women with schizophrenia. We aim to quantify the clinical course of schizophrenia in men and women on premorbid hospitalizations and prescription drugs, age at diagnosis, pharmacological treatment, comorbidity, number of re-hospitalizations, and mortality. Our nationwide cohort study included all patients admitted for the first time to hospital during 2000–2014 for schizophrenia or schizo-affective disorder in Finland. Gender differences were compared with logistic regression, by calculating incidence rates, and mortality was assessed with Cox proportional hazard model. We included 7142 women and 9006 men with schizophrenia/schizo-affective disorder and found that both women (71%) and men (70%) had often been hospitalized for another psychiatric disorder in the 5 years before diagnosis. In women, the last psychiatric hospitalization before schizophrenia/schizo-affective diagnosis was often for mood disorders (62%, OR 2.56, 95% CI 2.28–2.87). Men were diagnosed earlier (mean 34.4 [SD12.6] vs. 38.2 [SD 13.8]) with peak incidence around 22, while incidence in women declining only slowly between age 18 and 65. During ten years follow-up, 69.5% of both genders needed at least one re-hospitalization, with slightly more hospitalizations in women. Women were less often prescribed clozapine or long-acting antipsychotics. Mortality was lower in women (HR = 0.54, 95% CI 0.50–0.60), with fewer suicide and cardiovascular deaths, but more cancer deaths. These results suggest a diagnostic delay for women, which might be shortened by screening women aged 20–65 participating in affective disorder programs. As number of hospitalizations is not lower for women, clinicians should take care not to undertreat women with schizophrenia.
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- Houben, Alexander J. P., et al.
(author)
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The Eocene-Oligocene transition : Changes in sea level, temperature or both?
- 2012
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In: Palaeogeography, Palaeoclimatology, Palaeoecology. - : Elsevier BV. - 0031-0182 .- 1872-616X. ; 335, s. 75-83
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Journal article (peer-reviewed)abstract
- The Eocene-Oligocene Transition (EOT similar to 34 Ma) reflects the onset of major Antarctic glaciation. The primary geochemical signature of the EOT is two similar to 300 kyr spaced shifts in increasing deep-sea oxygen isotope values, possibly reflecting both global cooling a nd/or increasing ice volume. A way to assess the respective contribution of continental ice is to quantify concomitant glacio-eustatic sea level change. This is usually expressed in relatively shallow marine depositional settings. One potentially suitable region is in the Vicentinian Alps, NE Italy, where marginal marine deposits document sea level changes during the;EOT. By correlating stable isotope-, bio- and magnetostratigraphic information between three distant regions, we are able to relate the shallow marine sections to the Pacific oxygen isotope record from Ocean Drilling Program (ODP) Site 1218 of Coxall et al. (2005). Microfacies, sedimentological, and biotic analysis suggests that associated with the first isotope shift (EOT-1) sea level fell similar to 20 m, and with the ultimate shift, the Oligocene Isotope Event 1 (Oi-1) sea level fell some 50-60 m. Distribution patterns of temperature sensitive dinoflagellates from a coeval central Italian section reveal that the early stages of the EOT were accompanied by sea surface cooling, whereas no sustained cooling is noted in association with the Oi-1. This suggests that the initial EOT shift(s) reflect a mixed signal of ice volume and temperature whereas the Oi-1 primarily reflects expansion of the Antarctic cryosphere.
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