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1.	Bakhiet, M, et al. (author) Human and rodent interferon-gamma as a growth factor for Trypanosoma brucei 1996 In: European journal of immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 26:6, s. 1359-1364 Journal article (peer-reviewed)
2.	Bakhiet, M, et al. (author) Induction of interferon-gamma, transforming growth factor-beta, and interleukin-4 in mouse strains with different susceptibilities to Trypanosoma brucei brucei 1996 In: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. - : Mary Ann Liebert Inc. - 1079-9907. ; 16:6, s. 427-433 Journal article (peer-reviewed)
3.	Zhang, GX, et al. (author) Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis 1996 In: The Journal of experimental medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 184:2, s. 349-356 Journal article (peer-reviewed)abstract CD4+ T cells have been shown to be crucial in the development of experimental autoimmune myasthenia gravis (EAMG). The role of CD8+ T cells in EAMG is less well established. We previously showed that antibody depletion of CD8+ T cells in rats effectively suppresses EAMG. To further study the role and relationship of CD4+ versus CD8+ T cells in induction of EAMG, CD4-/-, CD8-/-, and CD4-8- mutant C57BL/6 mice and the parent CD4+8- wild-type mice were immunized with Torpedo acetylcholine receptor (AChR) plus complete Freund's adjuvant. Clinical EAMG was nearly completely prevented in CD4-8-, CD4-/-, and CD8-/- mice. This was associated with strongly reduced AChR-specific T and B cell responses, and with reduced levels of AChR-reactive interferon gamma (IFN-gamma) and interleukin 4 (IL-4) mRNA-expressing cells in lymphoid organs when compared with CD4+8+ wild-type mice. We conclude that (a) both CD4+ and CD8+ T cells are essential for development of EAMG, and a collaboration between these cell types may be necessary; (b) CD4+ as well as CD8+ T cells secrete IFN-gamma and IL-4, and both cytokines are involved in the development of EAMG; and (c), besides T cells, other immune cells might also be responsible for help of anti-AChR antibody production.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Bakhiet, M (3); Olsson, T (3); Kristensson, K (2); VanDerMeide, P (2); Link, H (1); Hojeberg, B (1); show more...; Wigzell, H (1); Buscher, P (1); Zhang, GX (1); vanderMeide, PH (1); Xiao, BG (1); Mhlanga, J (1); Lycke, N (1); Ljungdahl, A (1); show less...

University: Karolinska Institutet (3)

Language: English (3)

Year: 1996 (3)

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