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Träfflista för sökning "WFRF:(von der Linden Anja) "

Search: WFRF:(von der Linden Anja)

  • Result 1-3 of 3
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1.
  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
  •  
2.
  • Kelly, Patrick L., et al. (author)
  • Constraints on the Hubble constant from supernova Refsdal's reappearance
  • 2023
  • In: Science. - 0036-8075 .- 1095-9203. ; 380:6649
  • Journal article (peer-reviewed)abstract
    • The gravitationally lensed supernova Refsdal appeared in multiple images produced through gravitational lensing by a massive foreground galaxy cluster. After the supernova appeared in 2014, lens models of the galaxy cluster predicted that an additional image of the supernova would appear in 2015, which was subsequently observed. We use the time delays between the images to perform a blinded measurement of the expansion rate of the Universe, quantified by the Hubble constant (H0). Using eight cluster lens models, we infer kilometers per second per megaparsec. Using the two models most consistent with the observations, we find kilometers per second per megaparsec. The observations are best reproduced by models that assign dark-matter halos to individual galaxies and the overall cluster.
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3.
  • Siebzehnrübl, Florian A., et al. (author)
  • Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition
  • 2018
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 115:37, s. 8765-8774
  • Journal article (peer-reviewed)abstract
    • Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is expressed during embryonic development and throughout life, clinical HD usually manifests later in adulthood. A number of studies document neurodevelopmental changes associated with mutant HTT, but whether these are reversible under therapy remains unclear. Here, we identify very early behavioral, molecular, and cellular changes in preweaning transgenic HD rats and mice. Reduced ultrasonic vocalization, loss of prepulse inhibition, and increased risk taking are accompanied by disturbances of dopaminergic regulation in vivo, reduced neuronal differentiation capacity in subventricular zone stem/progenitor cells, and impaired neuronal and oligodendrocyte differentiation of mouse embryo-derived neural stem cells in vitro. Interventional treatment of this early phenotype with the histone deacetylase inhibitor (HDACi) LBH589 led to significant improvement in behavioral changes and markers of dopaminergic neurotransmission and complete reversal of aberrant neuronal differentiation in vitro and in vivo. Our data support the notion that neurodevelopmental changes contribute to the prodromal phase of HD and that early, presymptomatic intervention using HDACi may represent a promising novel treatment approach for HD.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (2)
other academic/artistic (1)
Author/Editor
Rothhaupt, Karl-Otto (1)
Weigend, Maximilian (1)
Farrell, Katharine N ... (1)
Islar, Mine (1)
Krause, Torsten (1)
Uddling, Johan, 1972 (1)
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Alexanderson, Helena (1)
Schneider, Christoph (1)
Battiston, Roberto (1)
Lukic, Marko (1)
Pereira, Laura (1)
Riggi, Laura (1)
Cattaneo, Claudio (1)
Jung, Martin (1)
Andresen, Louise C. (1)
Kasimir, Åsa (1)
Wang-Erlandsson, Lan (1)
Sutherland, William ... (1)
Boonstra, Wiebren J. (1)
Vajda, Vivi (1)
Svenningsson, Per (1)
Pascual, Unai (1)
Tscharntke, Teja (1)
Brown, Calum (1)
Peterson, Gustaf (1)
Meyer, Carsten (1)
Seppelt, Ralf (1)
Johansson, Maria (1)
Martin, Jean Louis (1)
Olsson, Urban (1)
Hortal, Joaquin (1)
Buckley, Yvonne (1)
Petrovan, Silviu (1)
Schindler, Stefan (1)
Carvalho, Joana (1)
Amo, Luisa (1)
Machordom, Annie (1)
De Smedt, Pallieter (1)
Lindkvist, Emilie (1)
Matos-Maraví, Pável (1)
Bacon, Christine D. (1)
Silvestro, Daniele (1)
Mascarenhas, André (1)
McPhearson, Timon (1)
Tengö, Maria (1)
Morales, Manuel B. (1)
Foley, Ryan J. (1)
Müller, Jörg (1)
Kanka, Robert (1)
Lehikoinen, Aleksi (1)
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University
Lund University (2)
Royal Institute of Technology (1)
Stockholm University (1)
Mid Sweden University (1)
Chalmers University of Technology (1)
Karolinska Institutet (1)
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Swedish University of Agricultural Sciences (1)
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Language
English (3)
Research subject (UKÄ/SCB)
Natural sciences (2)
Engineering and Technology (1)
Medical and Health Sciences (1)
Social Sciences (1)

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