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Search: L773:1369 0523

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  • Gaist, D, et al. (author)
  • Stroke research in GenomEUtwin
  • 2003
  • In: Twin research : the official journal of the International Society for Twin Studies. - : Cambridge University Press (CUP). - 1369-0523. ; 6:5, s. 442-447
  • Journal article (peer-reviewed)
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  • Larsson, Mats, et al. (author)
  • Importance of genetic effects for characteristics of the human iris
  • 2003
  • In: Twin research. - : Cambridge University Press (CUP). - 1369-0523 .- 2053-6003 .- 0000-0000. ; 6:3, s. 192-200
  • Journal article (peer-reviewed)abstract
    • The relative importance of genetic influences (heritability) on five general textural quality characteristics of the human iris was assessed using sex and age limitation models. Colour photographs of irises were available from 100 monozygotic twin pairs, 99 dizygotic twin pairs, and 99 unrelated randomly paired age-matched German subjects. Comparative scales were constructed and two judges who were blind to zygosity independently rated five characteristic of the subjects' left iris. Inter-rater reliabilities were larger than .90 for all five scales. The heritabilities for the five iris characteristics ranged from .51-.90. No sex-specific genetic factors were found for the iris characteristics. Age-group differences in heritability were found for one of the five iris characteristics — "distinction of white dot rings". Heritability was greater for the older cohort (90%) than the younger (73%). The iris characteristics that showed the next highest additive-genetic effect were "contractional furrows" (78%) and "frequency of crypts" in the main stroma leaf (66%).
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  • Litton, JE, et al. (author)
  • Data modeling and data communication in GenomEUtwin
  • 2003
  • In: Twin research : the official journal of the International Society for Twin Studies. - : Cambridge University Press (CUP). - 1369-0523. ; 6:5, s. 383-390
  • Journal article (peer-reviewed)
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  • Pedersen, NL, et al. (author)
  • The Swedish Twin Registry in the third millennium
  • 2002
  • In: Twin research : the official journal of the International Society for Twin Studies. - : Cambridge University Press (CUP). - 1369-0523. ; 5:5, s. 427-432
  • Journal article (peer-reviewed)
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  • Romeis, JC, et al. (author)
  • The genetics of middle-age spread in middle-class males
  • 2004
  • In: Twin research : the official journal of the International Society for Twin Studies. - : Cambridge University Press (CUP). - 1369-0523. ; 7:6, s. 596-602
  • Journal article (peer-reviewed)
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  • Skytthe, A, et al. (author)
  • Longevity studies in GenomEUtwin
  • 2003
  • In: Twin research : the official journal of the International Society for Twin Studies. - 1369-0523. ; 6:5, s. 448-454
  • Journal article (peer-reviewed)
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  • Svensson, DA, et al. (author)
  • Genetic and environmental influences on expression of recurrent headache as a function of the reporting age in twins
  • 2002
  • In: Twin research : the official journal of the International Society for Twin Studies. - : Cambridge University Press (CUP). - 1369-0523. ; 5:4, s. 277-286
  • Journal article (peer-reviewed)abstract
    • To explore age-related mechanisms in the expression of recurrent headache, we evaluated whether genetic and environmental influences are a function of the reporting age using questionnaire information that was gathered in 1973 for 15- to 47-year-old Swedish twins (n =12,606 twin pairs). Liability to mixed headache (mild migraine and tension-type headache) was explained by non-additive genetic influences (49%) in men aged from 15 to 30 years and additive genetic plus shared environmental influences (28%) in men aged from 31 to 47 years. In women, the explained proportion of variance, which was mainly due to additive genetic effects, ranged from 61% in adolescent twins to 12% in twins aged from 41 to 47 years, whereas individual specific environmental variance was significantly lower in twins aged from 15 to 20 years than in twins aged from 21 to 30 years. Liability to migrainous headache (more severe migraine) was explained by non-addi-tive genetic influences in men, 32% in young men and 45% in old men, while total phenotypic variance was significantly lower in young men than in old men. In women, the explained proportion of variance ranged from 91% in the youngest age group to 37% in the oldest age group, with major contributions from non-additive effects in young and old women (15–20 years and 41–47 years, respectively) and additive genetic effects in intermediate age groups (21–40 years). While total variance showed a positive age trend, genetic variance tended to be stable across age groups, whereas individual specific environmental variance was significantly lower in adolescent women as compared to older women.
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