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1.	Albshesh, Ahmad, et al. (author) Effectiveness of Third-Class Biologic Treatment in Crohn's Disease : A Multi-Center Retrospective Cohort Study 2021 In: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 10:13 Journal article (peer-reviewed)abstract Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn's disease (CD) failing anti- Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described.Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD.Results: Two-hundred and four patients were included; 156/204 (76%) patients received VDZ as a second- and UST as a third-class therapy (group A); the remaining 48/204 (24%) patients received UST as a second- and VDZ as a third-class therapy (group B). At week 16-22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9); 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9); 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5).Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent.
2.	Kopylov, Uri, et al. (author) Small bowel capsule endoscopy in the management of established Crohn's disease: clinical impact, safety, and correlation with inflammatory biomarkers. 2015 In: Inflammatory Bowel Diseases. - 1536-4844. ; 21:1, s. 93-100 Journal article (peer-reviewed)abstract Multiple studies have established the superior diagnostic accuracy of video capsule endoscopy (VCE) for the diagnosis of small bowel (SB) Crohn's disease (CD). However, data on the clinical impact of VCE in patients with established CD are scarce. The aim of this study was to examine the impact and safety of VCE on the clinical management of patients with established CD.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Kopylov, Uri (2); Afif, Waqqas (2); Raine, Tim (1); Armuzzi, Alessandro (1); Burisch, Johan (1); Gisbert, Javier P. (1); show more...; Magro, Fernando (1); Yanai, Henit (1); Albshesh, Ahmad (1); Taylor, Joshua (1); Savarino, Edoardo, V (1); Truyens, Marie (1); Ribaldone, Davide G. (1); Shitrit, Ariella Bar ... (1); Fibelman, Morine (1); Molander, Pauliina (1); Liefferinckx, Claire (1); Nancey, Stephane (1); Korani, Mohamed (1); Rutka, Mariann (1); Barreiro-de Acosta, ... (1); Domislovic, Viktor (1); Suris, Gerard (1); Eriksson, Carl, 1981 ... (1); Alves, Catarina (1); Mpitouli, Afroditi (1); di Jiang, Caroline (1); Tepes, Katja (1); Coletta, Marina (1); Foteinogiannopoulou, ... (1); Amir-Barak, Hadar (1); Attauabi, Mohamed (1); Seidelin, Jakob (1); Marinelli, Carla (1); Lobaton, Triana (1); Pugliese, Daniela (1); Maharshak, Nitsan (1); Cremer, Anneline (1); Limdi, Jimmy K. (1); Molnár, Tamás (1); Otero-Alvarin, Borja (1); Krznaric, Zeljko (1); Karmiris, Konstantin ... (1); Drobne, David (1); Koutroubakis, Ioanni ... (1); Chaparro, Maria (1); Toth, Ervin (1); Eliakim, Rami (1); Koulaouzidis, Anasta ... (1); Wurm Johansson, Gabr ... (1); show less...

University: Örebro University (1); Lund University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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