| 1. |
- Aad, G, et al.
(author)
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- 2015
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swepub:Mat__t
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| 2. |
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| 3. |
- Panda, Pritam Kumar, PhD Student, 1991-, et al.
(author)
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Molecular nanoinformatics approach assessing the biocompatibility of biogenic silver nanoparticles with channelized intrinsic steatosis and apoptosis
- 2022
-
In: Green Chemistry. - : Royal Society of Chemistry (RSC). - 1463-9262 .- 1463-9270. ; 24:3, s. 1190-1210
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Journal article (peer-reviewed)abstract
- The developmental rapidity of nanotechnology poses higher risks of exposure to humans and the environment through manufactured nanomaterials. The multitude of biological interfaces, such as DNA, proteins, membranes, and cell organelles, which come in contact with nanoparticles, is influenced by colloidal and dynamic forces. Consequently, the ensued nano-bio interface depends on dynamic forces, encompasses many cellular absorption mechanisms along with various biocatalytic activities, and biocompatibility that needs to be investigated in detail. Addressing the issue, the study offers a novel green synthesis strategy for antibacterial AgNPs with higher biocompatibility and elucidates the mechanistic in vivo biocompatibility of silver nanoparticles (AgNPs) at the cellular and molecular levels. The analysis ascertained the biosynthesis of G-AgNPs with the size of 25 ± 10 nm and zeta potential of-29.2 ± 3.0 mV exhibiting LC50 of 47.2 μg mL-1 in embryonic zebrafish. It revealed the mechanism as a consequence of abnormal physiological metabolism in oxidative stress and neutral lipid metabolism due to dose-dependent interaction with proteins such as he1a, sod1, PEX protein family, and tp53 involving amino acids such as arginine, glutamine and leucine leading to improper apoptosis. The research gave a detailed insight into the role of diverse AgNPs-protein interactions with a unique combinatorial approach from first-principles density functional theory and in silico analyses, thus paving a new pathway to comprehending their intrinsic properties and usage.
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| 4. |
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| 5. |
- Verma, Malvika, et al.
(author)
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A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
- 2019
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In: Science Translational Medicine. - : AMER ASSOC ADVANCEMENT SCIENCE. - 1946-6234 .- 1946-6242. ; 11:483
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Journal article (peer-reviewed)abstract
- Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.
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| 6. |
- Verma, Suresh K., et al.
(author)
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Altered electrochemical properties of iron oxide nanoparticles by carbon enhance molecular biocompatibility through discrepant atomic interaction
- 2021
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In: MATERIALS TODAY BIO. - : Elsevier. - 2590-0064. ; 12
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Journal article (peer-reviewed)abstract
- Recent advancement in nanotechnology seeks exploration of new techniques for improvement in the molecular, chemical, and biological properties of nanoparticles. In this study, carbon modification of octahedral-shaped magnetic nanoparticles (MNPs) was done using two-step chemical processes with sucrose as a carbon source for improvement in their electrochemical application and higher molecular biocompatibility. X-ray diffraction analysis and electron microscopy confirmed the alteration in single-phase octahedral morphology and carbon attachment in Fe3O4 structure. The magnetization saturation and BET surface area for Fe3O4, Fe3O4/C, and alpha-Fe2O3/C were measured as 90, 86, and 27 emu/g and 16, 56, and 89 m2/g with an average pore size less than 7 nm. Cyclic voltammogram and galvanostatic charge/discharge studies showed the highest specific capacitance of carbon-modified Fe3O4 and alpha-Fe2O3 as 213 F/g and 192 F/g. The in vivo biological effect of altered physicochemical properties of Fe3O4 and alpha-Fe2O3 was assessed at the cellular and molecular level with embryonic zebrafish. Mechanistic in vivo toxicity analysis showed a reduction in oxidative stress in carbon-modified alpha-Fe2O3 exposed zebrafish embryos compared to Fe3O4 due to despaired infiuential atomic interaction with sod1 protein along with significant less morphological abnormalities and apoptosis. The study provided insight into improving the characteristic of MNPs for electrochemical application and higher biological biocompatibility.
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| 7. |
- Araujo, Carlos Moyses, et al.
(author)
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Disorder-induced Room Temperature Ferromagnetism in Glassy Chromites
- 2014
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 4, s. 4686-
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Journal article (peer-reviewed)abstract
- We report an unusual robust ferromagnetic order above room temperature upon amorphization of perovskite [YCrO3] in pulsed laser deposited thin films. This is contrary to the usual expected formation of a spin glass magnetic state in the resulting disordered structure. To understand the underlying physics of this phenomenon, we combine advanced spectroscopic techniques and first-principles calculations. We find that the observed order-disorder transformation is accompanied by an insulator-metal transition arising from a wide distribution of Cr-O-Cr bond angles and the consequent metallization through free carriers. Similar results also found in YbCrO3-films suggest that the observed phenomenon is more general and should, in principle, apply to a wider range of oxide systems. The ability to tailor ferromagnetic order above room temperature in oxide materials opens up many possibilities for novel technological applications of this counter intuitive effect.
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| 8. |
- Arslanov, Temirlan R., et al.
(author)
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Pressure control of magnetic clusters in strongly inhomogeneous ferromagnetic chalcopyrites
- 2015
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5, s. 7720-
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Journal article (peer-reviewed)abstract
- Room-temperature ferromagnetism in Mn-doped chalcopyrites is a desire aspect when applying those materials to spin electronics. However, dominance of high Curie-temperatures due to cluster formation or inhomogeneities limited their consideration. Here we report how an external perturbation such as applied hydrostatic pressure in CdGeP2:Mn induces a two serial magnetic transitions from ferromagnet to non-magnet state at room temperature. This effect is related to the unconventional properties of created MnP magnetic clusters within the host material. Such behavior is also discussed in connection with ab initio density functional calculations, where the structural properties of MnP indicate magnetic transitions as function of pressure as observed experimentally. Our results point out new ways to obtain controlled response of embedded magnetic clusters.
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| 9. |
- Bhojani, Amit K., et al.
(author)
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Carbon-based monochalcogenides for efficient solar and heat energy harvesting
- 2023
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In: Applied Surface Science. - : Elsevier. - 0169-4332 .- 1873-5584. ; 608
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Journal article (peer-reviewed)abstract
- A new generation of two-dimensional (2D) material has captivated significant attention in the energy conversion field owing to their promising optoelectronics and thermoelectric applications. The present work involves the systematic investigation of fundamental properties of single-layered 2D carbon-based monochalcogenides (CS, CSe, CTe) with planar, buckled and puckered geometry within the framework of density functional theory (DFT). The structural and lattice dynamics analysis disclose that puckered and buckled configurations are energetically and dynamically stable whereas planar structures depict instability. The anisotropic group velocity of longitu-dinal acoustic (LA) and transverse acoustic (TA) phonon modes in puckered systems may render the charac-teristics thermal transport properties. Additionally, for the first time, we scrutinized the thermoelectric and optical properties of these materials. At room temperature, the electron carrier mobilities are 174.698 and 160.830 m(2)V(-1)s(-1) of puckered and buckled CS systems, respectively are highest among all structures. The computed Seebeck coefficient, electrical conductivity and power factor manifests the high thermoelectric transport properties of puckered CS material. Further, the calculated solar parameters demonstrate an excep-tionally high-power conversion efficiency of 19.61 % for puckered CTe. Present work indicates that puckered phase of CS and CTe show their potential for the heat and solar energy harvesting devices, respectively.
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| 10. |
- Gerkin, Richard C., et al.
(author)
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Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms
- 2021
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In: Chemical Senses. - : Oxford University Press (OUP). - 0379-864X .- 1464-3553. ; 46
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Journal article (peer-reviewed)abstract
- In a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0–100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19−; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19− groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: −82.5 ± 27.2 points; C19−: −59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0–10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4 < OR < 10). Once independently validated, this tool could be deployed when viral lab tests are impractical or unavailable.
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| 11. |
- Guo, J. H., et al.
(author)
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X-ray spectroscopic study of the charge state and local ordering of room-temperature ferromagnetic Mn-doped ZnO
- 2007
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In: Journal of Physics. - : IOP Publishing. - 0953-8984 .- 1361-648X. ; 19:17
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Journal article (peer-reviewed)abstract
- The charge state and local ordering of Mn doped into a pulsed laser deposited single-phase thin film of ZnO are investigated by using x-ray absorption spectroscopy at the O K-edge, Mn K-edge and L-edge, and x-ray emission spectroscopy at the O K-edge and Mn L-edge. This film is ferromagnetic at room temperature. EXAFS measurement shows that Mn2+ replaces the Zn site in tetrahedral symmetry, and there is no evidence for either metallic Mn or MnO in the film. Upon Mn doping, the top of O 2p valence band extends into the bandgap, indicating additional charge carriers being created.
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| 12. |
- Hwang, J., et al.
(author)
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Hydrogen storage enhancement via transition metal decoration on metal organic frameworks : A first-principles study
- 2012
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In: Nano. - 1793-2920. ; 7:6, s. 1250044-
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Journal article (peer-reviewed)abstract
- We investigate the hydrogen storage capacity of the light transition metal (TM)-decorated metal organic frameworks (MOFs) by performing ab initio density functional theory calculations. We find that among all the light TM elements, divalent Ti and Fe are suitable for decorating MOFs to enhance the hydrogen uptake, considering the H2 binding energy on the TM atom and the reversibly usable number of H2 molecules attached to the metal site. In general, the magnetization of metal atoms undergoes a high-spin to low-spin state transition when H2 molecules are adsorbed, which helps to stabilize the system energetically. By analyzing the projected density of states on each TM atom, it is shown that the d-level shift induced by the ligand field of the adsorbed H2 molecules contributes substantially to the H 2 binding strength. We also study the stability of selected TM-decorated nanostructures against the attack of foreign molecules by examining the energetics of those contaminating molecules around the metal sites.
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| 13. |
- Jha, Ealisha, et al.
(author)
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Intrinsic atomic interaction at molecular proximal vicinity infer cellular biocompatibility of antibacterial nanopepper
- 2021
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In: Nanomedicine. - : Future Medicine. - 1743-5889 .- 1748-6963. ; 16:4, s. 307-322
-
Journal article (peer-reviewed)abstract
- Aim: Fabrication of nanopepper (NP) for antibacterial application and elucidation of its molecular and cellular biocompatibility. Materials & methods: Synthesis of NP was achieved using a high-energy ball milling method. Following characterization, its antibacterial activity and cellular and molecular biocompatibility were evaluated in vitro by experimental and computational approaches. Results: A total of 15 h of milling pepper produced NP with a size of 44 +/- 12 nm and zeta potential of -22 +/- 12 mV. Bulk pepper and NP showed antibacterial activity and an LC50 of 1.9 mu M and 2.1 mu M in HCT116 colon cells. Components of pepper, piperine and beta-caryophyllene were found to interact with superoxide dismutase [Cu-Zn] and apoptotic protease-activating factor-1-caspase-9 through different amino acids via H-bonds. Conclusion: NP exhibits significant antibacterial activity with cellular biocompatibility due to intrinsic atomic interaction.
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| 14. |
- Kadas, K., et al.
(author)
-
Surface relaxation and surface stress of 4d transition metals
- 2006
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In: Surface Science. - : Elsevier BV. - 0039-6028 .- 1879-2758. ; 600:2, s. 395-402
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Journal article (peer-reviewed)abstract
- Using the density functional theory formulated within the framework of the exact muffin-tin orbitals method, we present a systematic study of the top layer relaxation and surface stress of 4d transition metals. Our calculations predict layer contractions for most surfaces. We also find that the relaxations of the close packed surfaces decrease with increasing atomic number through the 4d series. We propose that the relaxation is mainly due to the reduction of the number of sp electrons in the surface layer relative to bulk. The surface stress is found to be very sensitive to the relaxation and, therefore, an accurate determination of the layer relaxation is necessary for obtaining reliable values for the surface stress. Comparing the top layer relaxations for the close packed surfaces, we see essential deviations between data derived in different ab initio calculations. At the same time, the overall trend for the present surface stress of 4d metals is in reasonable agreement with recent full-potential data.
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| 15. |
- Kotmool, K., et al.
(author)
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High pressure-induced distortion in face-centered cubic phase of thallium
- 2016
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In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:40, s. 11143-11147
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Journal article (peer-reviewed)abstract
- The complex and unusual high-pressure phase transition of III-A (i.e. Al, Ga, and In) metals have been investigated in the last several decades because of their interesting periodic table position between the elements having metallic and covalent bonding. Our present first principles-based electronic structure calculations and experimental investigation have revealed the unusual distortion in face-centered cubic (f.c.c.) phase of the heavy element thallium (Tl) induced by the high pressure. We have predicted body-centered tetragonal (b.c.t) phase at 83 GPa using an evolutionary algorithm coupled with ab initio calculations, and this prediction has been confirmed with a slightly distorted parameter (√2 x a - c)/c lowered by 1% using an angle-dispersive X-ray diffraction technique. The density functional theory (DFT)-based calculations suggest that s-p mixing states and the valence-core overlapping of 6s and 5d states play the most important roles for the phase transitions along the pathway h.c.p → f.c.c. → b.c.t.
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| 16. |
- Kwon, S. K., et al.
(author)
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Surface energy and stress release by layer relaxation
- 2005
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In: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 72:23
-
Journal article (peer-reviewed)abstract
- The surface energy (gamma) and surface stress (tau) for semi-infinite close-packed surfaces of 4d transition metals have been calculated using ab initio total-energy methods. The moderate agreement between the present and former theoretical data for tau indicates the high level of numerical difficulty associated with such calculations. For the most close-packed surfaces, the present unrelaxed tau values follow the typical trend characteristic for the cohesive energy in nonmagnetic transition-metal series, whereas the relaxed tau values group around similar to 1 mJ/m(2), obtained for Y, Zr, and Ag, and similar to 3 mJ/m(2), calculated for Nb, Mo, Tc, Ru, Rh, and Pd. We have found that the average surface energy reduction upon layer relaxation is around 4%. At the same time, a large part of the surface stress is released during the surface relaxation process. To explain the observed behaviors, we have established a simple relationship, which connects the variations of gamma and tau to the layer relaxation. This relation reveals the principal factors determining the difference between the surface energy and stress release rates at 4d transition-metal surfaces.
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| 17. |
- Lou, H. B., et al.
(author)
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Pressure-induced amorphous-to-amorphous configuration change in Ca-Al metallic glasses
- 2012
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 2, s. 376-
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Journal article (peer-reviewed)abstract
- Pressure-induced amorphous-to-amorphous configuration changes in Ca-Al metallic glasses (MGs) were studied by performing in-situ room-temperature high-pressure x-ray diffraction up to about 40 GPa. Changes in compressibility at about 18 GPa, 15.5 GPa and 7.5 GPa during compression are detected in Ca80Al20, Ca72.7Al27.3, and Ca66.4Al33.6 MGs, respectively, whereas no clear change has been detected in the Ca50Al50 MG. The transfer of s electrons into d orbitals under pressure, reported for the pressure-induced phase transformations in pure polycrystalline Ca, is suggested to explain the observation of an amorphous-to-amorphous configuration change in this Ca-Al MG system. Results presented here show that the pressure induced amorphous-to-amorphous configuration is not limited to f electron-containing MGs.
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| 18. |
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| 19. |
- Rkhis, M., et al.
(author)
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Engineering the hydrogen storage properties of the perovskite hydride ZrNiH3 by uniaxial/biaxial strain
- 2022
-
In: International journal of hydrogen energy. - : Elsevier. - 0360-3199 .- 1879-3487. ; 47:5, s. 3022-3032
-
Journal article (peer-reviewed)abstract
- In the present work, the bonding length, electronic structure, stability, and dehydrogenation properties of the Perovskite-type ZrNiH3 hydride, under different uniaxial/biaxial strains are investigated through ab-initio calculations based on the plane-wave pseudopotential (PW-PP) approach. The findings reveal that the uniaxial/biaxial compressive and tensile strains are responsible for the structural deformation of the ZrNiH3 crystal structure, and its lattice deformation becomes more significant with decreasing or increasing the strain magnitude. Due to the strain energy contribution, the uniaxial/biaxial strain not only lowers the stability of ZrNiH3 but also decreases considerably the dehydrogenation enthalpy and decomposition temperature. Precisely, the formation enthalpy and decomposition temperature are reduced from -67.73 kJ/mol.H2 and 521 K for non-strained ZrNiH3 up to -33.73 kJ/mol.H2 and 259.5 K under maximal biaxial compression strain of epsilon = -6%, and to -50.99 kJ/mol.H2 and 392.23 K for the maximal biaxial tensile strain of epsilon = +6%. The same phenomenon has been also observed for the uniaxial strain, where the formation enthalpy and decomposition temperature are both decreased to -39.36 kJ/mol.H2 and 302.78 K for a maximal uniaxial compressive strain of epsilon = - 12%, and to -51.86 kJ/mol.H2 and 399 K under the maximal uniaxial tensile strain of epsilon = +12%. Moreover, the densities of states analysis suggests that the strain-induced variation in the dehydrogenation and structural properties of ZrNiH3 are strongly related to the Fermi level value of total den- sities of states. These ab-initio calculations demonstrate insightful novel approach into the development of Zr-based intermetallic hydrides for hydrogen storage practical applications. (c) 2021 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.
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| 20. |
- Smirnova, E. A., et al.
(author)
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Effect of band filling on the pressure-induced structural transition in Mo-Re alloys
- 2002
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In: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 66:2
-
Journal article (peer-reviewed)abstract
- We report on a detailed investigation of the combined effect of alloying and compression on the structural stability of random bcc and hcp alloys in the Mo-Re system. We use the linear-muffin-tin-orbital Green's-function method within the coherent potential approximation (LMTO-GF-CPA) and the full-potential linear-muffin-tin-orbital (FP-LMTO) method. For pure Mo we find a bcc to hcp transition pressure to take place at 620 GPa (FP-LMTO) or 730 GPa Mbar (LMTO-GF-CPA). The calculated equation of states for Mo68Re32 alloy is in good agreement with the experimental data, and the calculated bcc-hcp transition pressure is above 400 GPa. This number is much higher than the one anticipated in earlier model calculations. The agreement between the model calculations, ab initio calculations, and the experiment is restored when self-consistent occupation numbers of sp and d electrons are used.
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| 21. |
- Tomer, Vijay K., et al.
(author)
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Superior visible light photocatalysis and low-operating temperature VOCs sensor using cubic Ag(0)-MoS2 loaded g-CN 3D porous hybrid
- 2019
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In: APPLIED MATERIALS TODAY. - : ELSEVIER. - 2352-9407. ; 16, s. 193-203
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Journal article (peer-reviewed)abstract
- Two-dimensional materials are incipient as an innovative class of multifunctional elements with promising attributes for energy and environmental applications. Herein, a novel nanohybrid consisting of Ag-MoS2 loaded mesoporous g-C3N4 (herein 'm-CN') with ordered structure was synthesized by a nanocasting method using cubic and ordered mesoporous silica (KIT-6) as a hard template. Due to its unique 3D mesoporous architecture, the as-synthesized Ag-MoS2 @m-CN nanohybrid revealed excellent visible-light absorption for enhanced charge separation of photo-induced e(-)-h(+) pairs to improve the degradation performance, high stability, and reusability with respect to Rhodamine B (RhB). The measured very high degradation efficiency is explained by synergistic effects from catalytically active Ag and MoS2 nanoparticles cumulatively decorated on the cubic mesoporous m-CN in form 3D mesoporous architecture. Additionally, the Ag-MoS2@m-CN nanohybrid exhibits high response and selectivity toward n-butanol gas at low-operating temperatures for reliable detection of volatile organic compounds (VOCs). The photocatalysis behavior and VOC sensing response of Ag-MoS2@m-CN nanohybrid material are discussed in detail for possible various application avenues toward environmental purifications and monitoring. (C) 2019 Elsevier Ltd. All rights reserved.
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| 22. |
- Umrao, S., et al.
(author)
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Anticarcinogenic activity of blue fluorescent hexagonal boron nitride quantum dots : as an effective enhancer for DNA cleavage activity of anticancer drug doxorubicin
- 2019
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In: MATERIALS TODAY BIO. - : ELSEVIER. - 2590-0064. ; 1
-
Journal article (peer-reviewed)abstract
- Blue fluorescent hexagonal boron nitride quantum dots (h-BNQDs) of similar to 10 nm size as an effective enhancer for DNA cleavage activity of anticancer drug doxorubicin (DOX) were synthesized using simple one-step hydrothermal disintegration of exfoliated hexagonal boron nitride at very low temperature similar to 120 degrees C. Boron nitride quantum dots ( BNQDs) at a concentration of 25 mu g/ml enhanced DNA cleavage activity of DOX up to 70% as checked by converting supercoiled fragment into nicked circular PBR322 DNA. The interaction of BNQDs with DOX is proportional to the concentration of BNQDs, with binding constant K-b similar to 0.07338 mu g/ml. In addition, ab initio theoretical results indicate that DOX is absorbed on BNQDs at the N-terminated edge with binding energy -1.075 eV and prevented the normal replication mechanisms in DNA. BNQDs have been shown to kill the breast cancer cell MCF-7 extensively as compared with the normal human keratinocyte cell HaCaT. The cytotoxicity of BNQDs may be correlated with reduced reactive oxygen species level and increased apoptosis in MCF-7 cells, which may be liable to enhance the anticancerous activity of DOX. The results provide a base to develop BNQD-DOX as a more effective anticancer drug.
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| 23. |
- Verma, Suresh K., et al.
(author)
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Determining factors for the nano-biocompatibility of cobalt oxide nanoparticles : proximal discrepancy in intrinsic atomic interactions at differential vicinage
- 2021
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In: Green Chemistry. - : Royal Society of Chemistry (RSC). - 1463-9262 .- 1463-9270. ; 23:9, s. 3439-3458
-
Journal article (peer-reviewed)abstract
- The abounding use of cobalt oxide nanoparticles (Co3O4) requires a detailed understanding of their environmental and biomedical nanotoxicity and an eminent solution to the associated hazards; molecular and atomic aspects of the subject are poorly understood. This study reconnoiters thein vitroandin vivonanotoxicity of Co3O4nanoparticles using human colon cell lines and the embryonic zebrafish model. The synthesis of Co3O4nanoparticles (G-CoONP) is delineatedviathe deployment of a medicinal herb,Calotropis gigantea, as an alternative greener solution; stable G-CoONP with a size of 41 ± 15 nm are attainable. Gas chromatography-mass spectroscopy (GCMS) analysis revealed the role of floral extract biomolecules in G-CoO NP synthesis. Thein vitroandin vivoeffects are accompanied by dose-dependent exposure at the molecular level by eliciting Sod1 and P53 genes up to 8.2 and 5.2 fold leading to a significant change in the reactive oxygen species and apoptosis level. It unraveled the toxicity of the cobalt oxide NP as increased apoptosis elicited by higher oxidative stress due to the accumulation and internalization of nanoparticles in cells and embryos. Green synthesized G-CoONP exhibited higher biocompatibility than commercial C-CoONP with reduced apoptosis and ROS in both human colon cell lines and zebrafish embryos.In silicoanalysis portrayed the intrinsic atomic interaction of Co3O4NP with cysteine, arginine, and histidine of oxidative stress (SOD1/sod1) and apoptosis (TP53/tp53) proteins leading to dysregulation of their structural and functional integrity in human and zebrafish, respectively. A proximal discrepancy in intrinsic atomic interaction due to the H-bonding and hydrophobic interaction at the differentialin vitroandin vivovicinage served as a key determinant factor for the cellular biocompatibility of Co3O4nanoparticles.
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| 24. |
- Williamson, Alice, et al.
(author)
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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
- 2023
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In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:6, s. 973-983
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Journal article (peer-reviewed)abstract
- Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits.
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| 25. |
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