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- Sieberts, SK, et al.
(författare)
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Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
- 2016
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 12460-
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Tidskriftsartikel (refereegranskat)abstract
- Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the comparative evaluation of predictions developed by 73 research groups using the most comprehensive available data and covering a wide range of state-of-the-art modelling methodologies. Despite a significant genetic heritability estimate of treatment non-response trait (h2=0.18, P value=0.02), no significant genetic contribution to prediction accuracy is observed. Results formally confirm the expectations of the rheumatology community that SNP information does not significantly improve predictive performance relative to standard clinical traits, thereby justifying a refocusing of future efforts on collection of other data.
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| 5. |
- Farnsworth, Wesley R., et al.
(författare)
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Dynamic Holocene glacial history of St. Jonsfjorden, Svalbard
- 2017
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Ingår i: Boreas. - : Wiley. - 0300-9483. ; 46:3, s. 585-603
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Tidskriftsartikel (refereegranskat)abstract
- Evidence of a dynamic Holocene glacial history is preserved in the terrestrial and marine archives of St. Jonsfjorden, a small fjord-system on the west coast of Spitsbergen, Svalbard. High-resolution, remotely sensed imagery from marine and terrestrial environments was used to construct geomorphological maps that highlight an intricate glacial history of the entire fjord-system. The geomorphology and stratigraphy indicate an early Holocene local glacier advance constrained to the Lateglacial–early Holocene transition. Identification and 14C dating of the thermophilous bivalve mollusc Modiolus modiolus to 10.0±0.12 cal. ka BP suggest a rapid northward migration of the species shortly after deglaciation. Further evidence enhances the understanding of the onset and subsequent climax of the Neoglacial-Little Ice Age in inner St. Jonsfjorden. The present-day terminus of Osbornebreen, the dominating glacier system in St. Jonsfjorden, is located over 8.5 km up-fjord from its Neoglacial maximum extent. Cross-cutting relationships suggest subsequent advances of all the smaller glaciers in the area following the break-up of Osbornebreen. Glacial deposits, landforms and their cross-cutting relationships observed in both terrestrial and marine settings imply a complex and highly dynamic environment through the later part of the Holocene.
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| 6. |
- Farnsworth, Wesley R., et al.
(författare)
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Holocene glacial history of Svalbard : Status, perspectives and challenges
- 2020
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Ingår i: Earth-Science Reviews. - : Elsevier BV. - 0012-8252. ; 208
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Tidskriftsartikel (refereegranskat)abstract
- We synthesize the current understanding of glacier activity on Svalbard from the end of the Late Pleistocene (12,000 yrs. before present) to the end of the Little Ice Age (c. 1920 AD). Our glacier history is derived from the SVALHOLA database, the first compilation of Holocene geochronology for Svalbard and the surrounding waters, including over 1,800 radiocarbon, terrestrial cosmogenic nuclide and optically stimulated luminescence ages. Data have been categorized by geological setting, uniformly (re-)calibrated, quality assessed and ultimately used to constrain glacier fluctuations (deglaciation, ice free conditions, glacier re-advances and ice marginal positions). We advance existing knowledge by mapping the extent and distribution of ice-cover during the Holocene glacial maximum and the glacial minimum, as well as present retreat rates (and percentages) within Early Holocene fjord-systems. Throughout the Holocene, Svalbard glaciers have responded to a varying combination of climatic, environmental and dynamic driving factors which influence both the extent and behavior of ice margins. We discuss the complexities of glacier systems and their dynamics in response to changes in climate. This review provides a holistic state of the art of Holocene glaciers on Svalbard, suitable for orienting future works which address gaps in our current knowledge.
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| 8. |
- Schomacker, Anders, et al.
(författare)
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Postglacial relative sea level change and glacier activity in the early and late Holocene: Wahlenbergfjorden, Nordaustlandet, Svalbard
- 2019
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Sediment cores from Kløverbladvatna, a threshold lake in Wahlenbergfjorden, Nordaustlandet, Svalbard were used to reconstruct Holocene glacier fluctuations. Meltwater from Etonbreen spills over a threshold to the lake, only when the glacier is significantly larger than at present. Lithological logging, loss-on-ignition, ITRAX scanning and radiocarbon dating of the cores show that Kløverbladvatna became isolated from Wahlenbergfjorden c. 5.4 cal. kyr BP due to glacioisostatic rebound. During the Late Holocene, laminated clayey gyttja from lacustrine organic production and surface runoff from the catchment accumulated in the lake. The lacustrine sedimentary record suggests that meltwater only spilled over the threshold at the peak of the surge of Etonbreen in AD 1938. Hence, we suggest that this was the largest extent of Etonbreen in the (mid-late) Holocene. In Palanderbukta, a tributary fjord to Wahlenbergfjorden, raised beaches were surveyed and organic material collected to determine the age of the beaches and reconstruct postglacial relative sea level change. The age of the postglacial raised beaches ranges from 10.7 cal. kyr BP at 50 m a.s.l. to 3.13 cal. kyr BP at 2 m a.s.l. The reconstructed postglacial relative sea level curve adds valuable spatial and chronological data to the relative sea level record of Nordaustlandet.
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- Schulz, A, et al.
(författare)
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Arctic ozone loss in threshold conditions: Match observations in 1997/1998 and 1998/1999
- 2001
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Ingår i: JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES. - : AMER GEOPHYSICAL UNION. - 0747-7309. ; 106:D7, s. 7495-7503
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Tidskriftsartikel (refereegranskat)abstract
- Chemical ozone loss rates inside the Arctic polar vortex were determined in early 1998 and early 1999 by using the Match technique based on coordinated ozonesonde measurements. These two winters provide the only opportunities in recent years to investigat
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- Wevers-de Boer, K. V. C., et al.
(författare)
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Four-month metacarpal bone mineral density loss predicts radiological joint damage progression after 1 year in patients with early rheumatoid arthritis: exploratory analyses from the IMPROVED study
- 2015
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ Publishing Group. - 0003-4967 .- 1468-2060. ; 74:2, s. 341-346
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Tidskriftsartikel (refereegranskat)abstract
- Aim To assess whether in early (rheumatoid) arthritis (RA) patients, metacarpal bone mineral density (BMD) loss after 4 months predicts radiological progression after 1 year of antirheumatic treatment. Methods Metacarpal BMD was measured 4 monthly during the first year by digital X-ray radiogrammetry (DXR-BMD) in patients participating in the IMPROVED study, a clinical trial in 610 patients with recent onset RA (2010 criteria) or undifferentiated arthritis, treated according to a remission (disease activity scoreless than1.6) steered strategy. With Sharp/van der Heijde progression greater than= 0.5 points after 1 year (yes/no) as dependent variable, univariate and multivariate logistic regression analyses were performed. Results Of 428 patients with DXR-BMD results and progression scores available, 28 (7%) had radiological progression after 1 year. Independent predictors for radiological progression were presence of baseline erosions (OR (95% CI) 6.5 (1.7 to 25)) and early DXR-BMD loss (OR (95% CI) 1.5 (1.1 to 2.0)). In 366 (86%) patients without baseline erosions, early DXR-BMD loss was the only independent predictor of progression (OR (95% CI) 2.0 (1.4 to 2.9)). Conclusions In early RA patients, metacarpal BMD loss after 4 months of treatment is an independent predictor of radiological progression after 1 year. In patients without baseline erosions, early metacarpal BMD loss is the main predictor of radiological progression.
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