| 1. |
- Leo, Ulf, et al.
(author)
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Analysis and Reflections
- 2014
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In: Enforcing Child Rights Globally. - 9789198053555 ; , s. 141-156
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Book chapter (peer-reviewed)
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| 2. |
- Alfredsson, Emma, et al.
(author)
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Background - Framework and Content of the ITP programme
- 2016. - 1
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In: Realising Child Rights in Education : Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management - Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management. - 9789198226164 ; 1, s. 7-27
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Book chapter (other academic/artistic)
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| 3. |
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| 4. |
- Leo, Ulf, et al.
(author)
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Background
- 2014
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In: Enforcing Child Rights Globally. - 9789198053555 ; , s. 7-13
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Book chapter (peer-reviewed)
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| 5. |
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| 6. |
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| 7. |
- Leo, Ulf, et al.
(author)
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The Role of Change Agents
- 2014
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In: Enforcing Child Rights Globally. - 9789198053555 ; , s. 171-187
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Book chapter (peer-reviewed)
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| 8. |
- Rasmusson, Bodil, et al.
(author)
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Looking back and looking forward
- 2016. - 1
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In: Realising Child Rights in Education : Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management - Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management. - 9789198226164 ; 1, s. 217-225
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Book chapter (other academic/artistic)
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| 9. |
- Rasmusson, Bodil, et al.
(author)
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Mentors´Reflections
- 2016. - 1
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In: Realising Child Rights in Education : Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management - Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management. - 9789198226164 ; 1, s. 187-217
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Book chapter (other academic/artistic)
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| 10. |
- Rasmusson, Bodil, et al.
(author)
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Summing up
- 2015
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In: Change Projects from the International Training Programme: Child Rights, Classroom and School Management. Final reports. Batch 18.. - 9789198053531 ; Volume 7, s. 197-207
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Book chapter (peer-reviewed)
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| 11. |
- Wickenberg, Per, et al.
(author)
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Summing up - Batch 20 : Change Projects from the International Training Programme - Batch 20
- 2015
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In: Child Rights, Classroom and School Management, Batch 20 : Change Projects from the International Training Programme - Change Projects from the International Training Programme. - 9789198226126 ; , s. 225-232
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Book chapter (other academic/artistic)abstract
- Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. Theprogramme targets those in a position from which they can initiate processesof change in the education sector in their countries. During the programmeall participating teams initiate a change project in their respective countriesaiming at the realization of the intention of the Child Rights Convention inpolicy as well as in practice. This book contains the final reports from Batch20 with change agents from China, Colombia, DPR of Korea, Indonesia, Malawi,Mozambique, Namibia, Sri Lanka, Uganda, Viet Nam, and Zambia.
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| 12. |
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| 13. |
- Wångdahl Flinck, Agneta, et al.
(author)
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Summing up - Batch 21: Change Projects from the International Training Programme : Child Rights, Classroom and School Management - Batch 21
- 2016
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In: Child Rights, Classroom and School Management : Batch 21 - Batch 21. - 9789198226157
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Book chapter (other academic/artistic)abstract
- Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003.The programme targets those in a position from which they can initiate processesof change in the education sector in their countries. During the programmeall participating teams initiate a change project in their respectivecountries aiming at the realization of the intention of the Child Rights Conventionin policy as well as in practice. This book contains the final reportsfrom Batch 21 with change agents from Cambodia, China, Egypt, Ethiopia,Malawi, Namibia, South Africa, Tanzania, Viet Nam, and Zambia.
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| 14. |
- Andersson, Agneta, et al.
(author)
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DNA-streckkodning av marina växtplankton : Ett nytt verktyg i miljöövervakningen
- 2024
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Reports (other academic/artistic)abstract
- Växtplankton utgör grunden i den marina näringsväven och används världen över för att bestämma miljöstatus i hav och sjöar. De ingår exempelvis som en kvalitetsfaktor i EU:s vattendirektiv och havsmiljödirektiv. Det finns långa tidsserier av växtplanktonövervakning där analyserna utförts med mikroskopi. Det sker nu en snabb internationell utveckling av DNA-metoder för att övervaka växtplankton. Målsättningen med detta projekt var att utveckla en praktisk och robust DNA analysmetod som kan implementeras i svensk marin miljöövervakning. Vårt tillvägagångssätt var att följa med på ordinarie marina miljöövervakningsexpeditioner under ett års tid (2019–2020) och ta parallella havsvattenprov för så kallad DNA-streckkodning av växtplankton. Sammanlagt tog vi prov vid 19 övervakningsstationer som var spridda från Bottenviken i norr till Skagerrak i söder. Provtagningsfrekvensen var cirka 1 gång per månad. Praktiska metoder utarbetades för fältprovtagning, DNA-extraktion, sekvensering, bioinformatisk analys och taxonomisk annotering. Vi har även tagit fram system för datahantering hos nationell datavärd och gett förslag på en ny datatyp för nationellt datavärdskap för marinbiologi och oceanografi vid Svenskt Oceanografiskt Datacentrum (https://sharkweb. smhi.se/hamta-data/). En viktig del har varit att jämföra resultaten av DNA-streckkodning och mikroskopi. Resultaten visar att DNA-streckkodning ger ungefär dubbelt så högt biodiversitetsmått än mikroskopering, även om det skiljer sig åt mellan olika grupper av växtplankton. För att undersöka om DNA-streckkodning kan användas för kvantitativ analys tillsatte vi en intern standard till proverna bestående av syntetiskt DNA, men eftersom resultatet varierade så behöver man arbeta vidare med detta. Den relativa fördelningen av vanliga eukaryota växtplanktongrupper visade sig ha relativt bra överensstämmelse mellan DNA-streckkodning och mikroskopimåttet kolbiomassa, medan biovolym och abundans skiljde sig åt mer. DNA-streckkodning visade sig ge detaljerade utbredningsmönster av skadliga alger, till exempel för släktet Prymnesium bland häftalgerna (Coccolithophyceae). Vi har inom projektet kunnat utvärdera ekologiska drivkrafter för växtplanktonsamhällets diversitet och artsammansättning, genom att miljöövervakningen mäter många fysikalisk-kemiska parametrar. Både salthalt och närsalter visade sig ha stor inverkan på växtplanktonsamhällets sammansättning och diversitet. Sammanfattningsvis ser vi att den framtagna DNA-streckkodningsmetoden skulle vara ett bra komplement till den etablerade växtplanktonövervakningen.
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| 15. |
- Andersson, Agneta, et al.
(author)
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DNA-streckkodning kompletterar traditionell planktonanalys
- 2020
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In: Sveriges vattenmiljö - Kunskapsbank. - Göteborg : Havsmiljöinstitutet.
-
Research review (pop. science, debate, etc.)abstract
- Att filtrera några deciliter havsvatten och analysera DNA-innehållet ger snabbt svaret på vilka växtplankton som finns i våra hav. Det låter kanske som science fiction, men målet för projektet "DNA-streckkodning av marina växtplankton" är att tekniken ska vara redo för den svenska miljöövervakningen redan 2022.
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| 16. |
- Björkelund, Cecilia, 1948, et al.
(author)
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Secular trends in cardiovascular risk factors with a 36-year perspective: observations from 38- and 50-year-olds in the Population Study of women in Gothenburg
- 2008
-
In: Scandinavian Journal of Primary Health Care. - : Informa UK Limited. - 1502-7724 .- 0281-3432. ; 26:3, s. 140-6
-
Journal article (peer-reviewed)abstract
- Department of Public Health and Community Medicine/Primary Health Care, The Sahlgrenska Academy, University of Gothenburg, Sweden. cecilia.bjorkelund@allmed.gu.se OBJECTIVES: To study secular trends in cardiovascular risk factors in four different cohorts of women examined in 1968-1969, 1980-1981, 1992-1993 and 2004-2005. DESIGN: Comparison of four representative cohorts of 38- and 50-year-old women over a period of 36 years. SETTING: Gothenburg, Sweden with approximately 450,000 inhabitants. SUBJECTS: Four representative samples of 38- and 50-year-old women were invited to free health examinations (participation rate 59-90%, n =1901). MAIN OUTCOME MEASURES: Body mass index (BMI), systolic and diastolic blood pressure (SBP, DBP), leisure time exercise, use of antihypertensive medication, smoking, levels of haemoglobin, b-glucose, s-cholesterol, s-triglycerides and HDL-cholesterol. RESULTS: There was no significant difference in mean BMI from 1968-1969 versus 2004-2005. Mean leisure time exercise was significantly higher in later born cohorts; in 1968, around 15% were physically active compared with 40% in 2004. SBP and DBP, mean s-cholesterol and s-triglyceride levels were significantly lower in both 38- and 50-year-old cohorts in 2004-2005 versus 1968-1969. HDL-cholesterol (not measured until 1992-1993), showed a significantly higher mean level in 2004-2005. Reduction of risk factors was apparent in women with a high as well as low level of physical activity. Smoking declined most in women with high levels of physical activity. CONCLUSIONS: Several cardiovascular risk factors related to lifestyle have improved in middle-aged women from the 1960s until today. Most of the positive trends are observed in women with both low and high physical activity.
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| 17. |
- Bosaeus, Marja, et al.
(author)
-
Body Composition During Pregnancy: Longitudinal Changes and Method Comparisons
- 2020
-
In: Reproductive Sciences. - : Springer Science and Business Media LLC. - 1933-7191 .- 1933-7205. ; :27, s. 1477-1489
-
Journal article (peer-reviewed)abstract
- The Pregnancy Obesity Nutrition and Child Health study is a longitudinal study of reproductive health. Here we analyzed body composition of normal-weight and obese Swedish women by three methods during each trimester of pregnancy. Cross-sectional and longitudinal fat mass estimates using quantitative magnetic resonance (QMR) and bioelectrical impedance analysis (BIA) (Tanita MC-180MA-III) were compared with fat mass determined by air displacement plethysmography (ADP) in pregnancy weeks 8-12, 24-26, and 35-37 in normal-weight women (n = 122, BMI = 22.1 +/- 1.6 kg/m(2)) and obese women (n = 29, BMI = 34.6 +/- 3.6 kg/m(2)). ADP results were calculated from pregnancy-adjusted fat-free mass densities. Mean fat mass by QMR and ADP were similar in obese women, although with wide limits of agreement. In normal-weight women, QMR overestimated mean fat mass in all trimesters, with systematic overestimation at low fat mass values in trimesters 1 and 3. In obese women, fat mass by BIA was grossly underestimated and imprecise in all trimesters, especially at higher values in trimester 2. In normal-weight women, fat mass by BIA was moderately lower than by ADP in trimester 1, similar in trimester 2, and moderately higher in trimester 3. QMR and ADP assessed fat mass changes similarly in obese women, whereas BIA overestimated fat mass changes in normal-weight women. Mean fat mass and fat mass changes by QMR and pregnancy-adjusted ADP were similar in pregnant obese women. Mean fat mass by QMR and fat mass changes by BIA were higher than corresponding values determined by pregnancy-adjusted ADP in normal-weight women.
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| 18. |
- Carlsson, Noomi, et al.
(author)
-
Exploring experiences among adopters during the diffusion of a novel dance intervention in Sweden
- 2018
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In: International Journal of Qualitative Studies on Health and Well-being. - : Taylor & Francis. - 1748-2623 .- 1748-2631. ; 13:1
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Journal article (peer-reviewed)abstract
- There is a demand for interventions aimed at adolescent girls with psychosomatic problems. In 2013, positive results were reported from a dance intervention programme addressing girls with internalizing problems. The research team behind the intervention immediately received requests from municipalities and county councils interested in using the intervention. From an implementation point of view it is unclear what made the intervention spread without an active plan. The aim of this study was to explore adopters' experiences about the diffusion and initiation of a public health intervention targeting adolescent girls with internalizing problems. Interviews were conducted with 12 people who were engaged in initiating the intervention in different settings. Data were analysed using conventional content analysis, yielding three categories: perceived appeal and trustworthiness, convenient information, and contextual factors. The results reflected that the participants found that there was a need for an intervention and found the dance intervention to be evidence based and not too complex to perform. Further, there was available information on the project which could easily be distributed to decision makers and others. When initiating the intervention, factors related to economy, possibility for collaboration and recruitment were of importance.
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| 19. |
- Carlsson, Noomi, et al.
(author)
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How to minimize children’s environmental tobacco smoke exposure : an intervention in a clinical setting in high risk areas
- 2013
-
In: BMC Pediatrics. - 1471-2431 .- 1471-2431. ; 13, s. 76-
-
Journal article (peer-reviewed)abstract
- Background:Despite the low prevalence of daily smokers in Sweden, children are still being exposed to nvironmental tobacco smoke (ETS), primarily by their smoking parents. A prospective intervention study using ethods from Quality Improvement was performed in Child Health Care (CHC). The aim was to provide nurses with ew methods for motivating and supporting parents in their efforts to protect children from ETS exposure.Method:Collaborative learning was used to implement and test an intervention bundle. Twenty-two CHC nurses ecruited 86 families with small children which had at least one smoking parent. Using a bundle of interventions, urses met and had dialogues with the parents over a one-year period. A detailed questionnaire on cigarette onsumption and smoking policies in the home was answered by the parents at the beginning and at the end of he intervention, when children also took urine tests to determine cotinine levels.Results:Seventy-two families completed the study. Ten parents (11%) quit smoking. Thirty-two families (44%) ecreased their cigarette consumption. Forty-five families (63%) were outdoor smokers at follow up. The proportion f children with urinary cotinine values of >6 ng/ml had decreased.Conclusion:The intensified tobacco prevention in CHC improved smoking parents’ ability to protect their children rom ETS exposure.
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| 20. |
- Danielsson, Christian, et al.
(author)
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Exploration of human, rat, and rabbit embryonic cardiomyocytes suggests K-channel block as a common teratogenic mechanism
- 2013
-
In: Cardiovascular Research. - : Oxford University Press (OUP): Policy B. - 0008-6363 .- 1755-3245. ; 97:1, s. 23-32
-
Journal article (peer-reviewed)abstract
- Several drugs blocking the rapidly activating potassium (K-r) channel cause malformations (including cardiac defects) and embryonic death in animal teratology studies. In humans, these drugs have an established risk for acquired long-QT syndrome and arrhythmia. Recently, associations between cardiac defects and spontaneous abortions have been reported for drugs widely used in pregnancy (e.g. antidepressants), with long-QT syndrome risk. To investigate whether a common embryonic adverse-effect mechanism exists in the human, rat, and rabbit embryos, we made a comparative study of embryonic cardiomyocytes from all three species. less thanbrgreater than less thanbrgreater thanPatch-clamp and quantitative-mRNA measurements of K-r and slowly activating K (K-s) channels were performed on human, rat, and rabbit primary cardiomyocytes and cardiac samples from different embryo-foetal stages. The K-r channel was present when the heart started to beat in all species, but was, in contrast to human and rabbit, lost in rats in late organogenesis. The specific K-r-channel blocker E-4031 prolonged the action potential in a species- and development-dependent fashion, consistent with the observed K-r-channel expression pattern and reported sensitive periods of developmental toxicity. E-4031 also increased the QT interval and induced 2:1 atrio-ventricular block in multi-electrode array electrographic recordings of rat embryos. The K-s channel was expressed in human and rat throughout the embryo-foetal period but not in rabbit. less thanbrgreater than less thanbrgreater thanThis first comparison of mRNA expression, potassium currents, and action-potential characteristics, with and without a specific K-r-channel blocker in human, rat, and rabbit embryos provides evidence of K-r-channel inhibition as a common mechanism for embryonic malformations and death.
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| 21. |
- Dillner, Lena, et al.
(author)
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Randomized healthservices study of human papillomavirus-based management of low-grade cytological abnormalities.
- 2011
-
In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; okt, s. 151-159
-
Journal article (peer-reviewed)abstract
- Human Papillomavirus (HPV)-based management of women with borderline (ASCUS) or mildly abnormal (CINI) cervical cytology has been extensively studied in the research setting. We wished to assess safety and healthcare resource use of a real-life healthcare policy using HPV triaging.All 15 outpatient clinics involved in the organized population-based screening program in Stockholm, Sweden screening program were randomized to either continue with prior policy (colposcopy of all women with ASCUS/CINI) or to implement a policy with HPV triaging and colposcopy only of HPV-positive women. The trial enrolled the 3319 women that were diagnosed with ASCUS (n=1335) or CINI (n=1984) in Stockholm during 17(th) March 2003 to 16(th) January 2006. Detection of high-grade cervical lesions (CINII+) and health care cost consumption was studied by registry linkages.The proportion of histopathology-verified CINII+ was similar for the 2 policies (395/1752 women (22.5%; 95% Confidence interval (CI): 20,6-24,6%) had CINII+ diagnosed with HPV triaging policy, 318/1567 women (20.3%; 95%CI: 18,3-22,4%)) had CINII+ with colposcopy policy). 64% of women with ASCUS and 77% of women with CINI were HPV-positive. HPV-positivity was age-dependent, with 81% of women below 35 years of age and 44% of women above 45 years of age testing HPV-positive. HPV triaging was cost-effective only above 35 years of age.In conclusion, a real-life randomised healthservices study of HPV triaging of women with ASCUS/CINI demonstrated similar detection of CINII+ as colposcopy of all women.
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| 22. |
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| 23. |
- Grinnemo, Karl-Henrik, et al.
(author)
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Costimulation blockade induces tolerance to HESC transplanted to the testis and induces regulatory T-cells to HESC transplanted into the heart
- 2008
-
In: Stem Cells. - : Oxford University Press (OUP). - 1549-4918 .- 1066-5099. ; 26:7, s. 1850-1857
-
Journal article (peer-reviewed)abstract
- In order to study the ability of costimulation blockade to induce tolerance to human embryonic stem cells (HESC), severe combined immunodeficient (SCID), and immunocompetent C57BL/6 mice treated with costimulation blockade received intratesticular and intramyocardial HESC transplants. All SCID mice with intratesticular HESC transplants developed teratoma. When SCID mice were transplanted intramyocardially, only two of five mice developed teratoma-like tumors. C57BL/6 mice transplanted intratesticularly and treated with costimulation blockade all developed teratoma and were surrounded by CD4(+)CD25(+)Foxp3(+) T-cells, while isotype control treated recipients rejected their grafts. Most C57BL/6 mice transplanted intramyocardially and treated with costimulation blockade demonstrated lymphocytic infiltrates 1 month after transplantation, whereas one maintained its graft. Isolation of regulatory T-cells from intramyocardial transplanted recipients treated with costimulation blockade demonstrated specificity toward undifferentiated HESC and down-regulated naive T-cell activation toward HESC. These results demonstrate that costimulation blockade is sufficiently robust to induce tolerance to HESC in the immune-privileged environment of the testis. HESC specific regulatory T-cells developed to HESC transplanted to the heart and the success of transplantation was similar to that seen in SCID mice.
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| 24. |
- Gustavsson, Carolina, et al.
(author)
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Cerebrospinal fluid levels of insulin, leptin, and agouti-related protein in relation to BMI in pregnant women
- 2016
-
In: Obesity. - : Wiley. - 1930-7381. ; 24:6, s. 1299-1304
-
Journal article (peer-reviewed)abstract
- ObjectiveDuring pregnancy, metabolic interactions must be adapted, though neuroendocrine mechanisms for increased food intake are poorly understood. The objective of this study was to characterize differences in insulin, leptin, and agouti-related protein (AgRP) levels in serum and cerebrospinal fluid (CSF) in pregnant women with normal weight (NW) and pregnant women with overweight (OW) or obesity (OB). Placenta as a source for increased peripheral AgRP levels during pregnancy was also investigated. MethodsWomen were recruited at admission for elective cesarean section. Insulin, AgRP, and leptin were measured in serum and CSF from 30 NW, 25 OW, and 21 OB at term. Serum during pregnancy and placenta at term were collected for further AgRP analysis. ResultsImmunohistology showed placental production of AgRP and serum AgRP levels increased throughout pregnancy. CSF AgRP, leptin, and insulin levels were higher in OW and OB than NW. Serum leptin and insulin levels were higher and AgRP lower in OB than NW. ConclusionsHigh serum AgRP levels might protect from the suppressive effects of leptin during pregnancy. Pregnant women with OB and OW might further be protected from the suppressive effect of leptin by high CSF AgRP levels. Evidence was found, for the first time, of human placental AgRP production mirrored by levels in the circulation.
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| 25. |
- Hadimeri, Henrik, et al.
(author)
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A fixed protocol for outpatient clinic routines in the care of patients with severe renal failure
- 2013
-
In: Renal failure. - : Informa Healthcare. - 0886-022X .- 1525-6049. ; 35:6, s. 845-854
-
Journal article (peer-reviewed)abstract
- Background: The primary aim of this study was to assess whether a fixed protocol, using a specially trained team, for intermediate follow-up to fulfillment of guideline targets is non-inferior to conventional follow-up in the care of uraemic patients. A secondary aim was to investigate possible impact on patient outcome.Methods: The cohort comprised 424 patients from seven centers. Inclusion criteria were either serum creatinine exceeding 200 mu mol/l or calculated clearance below 30 ml/min, representing CKD 4 or 5a. Six centers followed a standardized protocol (group 1). One center provided controls (group 2). The study design was prospective and interventional. The variables measured were blood hemoglobin, bicarbonate, calcium, phosphate, intact parathyroid hormone, albumin, renal function variables, blood pressure and RAAS blockade. The number of patients achieving the set goals was analyzed as a time trend to determine if the intervention resulted in an improvement.Results: At baseline, group 1 had significantly lower GFR and higher serum creatinine, calcium, phosphate, calcium x phosphate product and bicarbonate, lower mean arterial pressure (MAP), systolic blood pressures and less use of RAAS. During the intervention, group 1 improved in the direction of guidelines for blood hemoglobin, albumin, bicarbonate and MAP. Outcome of secondary endpoints gave a risk of death of 30% in both groups, while the risk of renal replacement therapy was higher in group 1.Conclusions: However, the time to renal replacement therapy was significantly shorter in the intervention group, indicating that other variables than guideline achievements are important for the patient.
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