| 1. |
- Hilbert, Kevin, et al.
(author)
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Cortical and Subcortical Brain Alterations in Specific Phobia and Its Animal and Blood-Injection-Injury Subtypes: A Mega-Analysis From the ENIGMA Anxiety Working Group.
- 2024
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In: The American Journal of Psychiatry. - 1535-7228. ; 181:8, s. 728-740
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Journal article (peer-reviewed)abstract
- Specific phobia is a common anxiety disorder, but the literature on associated brain structure alterations exhibits substantial gaps. The ENIGMA Anxiety Working Group examined brain structure differences between individuals with specific phobias and healthy control subjects as well as between the animal and blood-injection-injury (BII) subtypes of specific phobia. Additionally, the authors investigated associations of brain structure with symptom severity and age (youths vs. adults).Data sets from 31 original studies were combined to create a final sample with 1,452 participants with phobia and 2,991 healthy participants (62.7% female; ages 5-90). Imaging processing and quality control were performed using established ENIGMA protocols. Subcortical volumes as well as cortical surface area and thickness were examined in a preregistered analysis.Compared with the healthy control group, the phobia group showed mostly smaller subcortical volumes, mixed surface differences, and larger cortical thickness across a substantial number of regions. The phobia subgroups also showed differences, including, as hypothesized, larger medial orbitofrontal cortex thickness in BII phobia (N=182) compared with animal phobia (N=739). All findings were driven by adult participants; no significant results were observed in children and adolescents.Brain alterations associated with specific phobia exceeded those of other anxiety disorders in comparable analyses in extent and effect size and were not limited to reductions in brain structure. Moreover, phenomenological differences between phobia subgroups were reflected in diverging neural underpinnings, including brain areas related to fear processing and higher cognitive processes. The findings implicate brain structure alterations in specific phobia, although subcortical alterations in particular may also relate to broader internalizing psychopathology.
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| 2. |
- Hudson, Lawrence N, et al.
(author)
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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
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In: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
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Journal article (peer-reviewed)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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| 3. |
- Zamora, Juan Carlos, et al.
(author)
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Considerations and consequences of allowing DNA sequence data as types of fungal taxa
- 2018
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In: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
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Journal article (peer-reviewed)abstract
- Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Behlke, Rico, et al.
(author)
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Solitary structures associated with short large-amplitude magnetic structures (SLAMS) upstream of the Earth's quasi-parallel bow shock
- 2004
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In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 31:16
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Journal article (peer-reviewed)abstract
- [1] For the first time, solitary waves (SWs) have been observed within short large-amplitude magnetic structures (SLAMS) upstream of the Earth's quasi-parallel bow shock. The SWs often occur as bipolar pulses in the electric field data and move parallel to the background magnetic field at velocities of v = 400–1200 km/s. They have peak-to-peak amplitudes in the parallel electric field of up to E′∥ = 65 mV/m and parallel scale sizes of L∥ ∼ 10 λD. The bipolar solitary waves exhibit negative potential structures of ∣Φ∥∣ = 0.4–2.2 V, i.e., eΦ∥/kTe ∼ 0.1. None of the theories commonly used to describe SWs adequately address these negative potential structures moving at velocities above the ion thermal speed in a weakly magnetized plasma.
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| 8. |
- Botling, Johan, et al.
(author)
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Biomarker Discovery in Non-Small Cell Lung Cancer : Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation
- 2013
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In: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 19:1, s. 194-204
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Journal article (peer-reviewed)abstract
- Purpose: Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far, the value of these multigene signatures in clinical practice is unclear, and the biologic importance of individual genes is difficult to assess, as the published signatures virtually do not overlap.Experimental Design: Here, we describe a novel single institute cohort, including 196 non-small lung cancers (NSCLC) with clinical information and long-term follow-up. Gene expression array data were used as a training set to screen for single genes with prognostic impact. The top 450 probe sets identified using a univariate Cox regression model (significance level P < 0.01) were tested in a meta-analysis including five publicly available independent lung cancer cohorts (n = 860).Results: The meta-analysis revealed 14 genes that were significantly associated with survival (P < 0.001) with a false discovery rate < 1%. The prognostic impact of one of these genes, the cell adhesion molecule 1 (CADM1), was confirmed by use of immunohistochemistry on tissue microarrays from 2 independent NSCLC cohorts, altogether including 617 NSCLC samples. Low CADM1 protein expression was significantly associated with shorter survival, with particular influence in the adenocarcinoma patient subgroup.Conclusions: Using a novel NSCLC cohort together with a meta-analysis validation approach, we have identified a set of single genes with independent prognostic impact. One of these genes, CADM1, was further established as an immunohistochemical marker with a potential application in clinical diagnostics. Clin Cancer Res; 19(1); 194-204. (c) 2012 AACR.
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| 9. |
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| 10. |
- Hudson, Lawrence N., et al.
(author)
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The PREDICTS database : a global database of how local terrestrial biodiversity responds to human impacts
- 2014
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In: Ecology and Evolution. - : Wiley. - 2045-7758. ; 4:24, s. 4701-4735
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Journal article (peer-reviewed)abstract
- Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups - including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems - ). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.
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| 11. |
- McGinn, Steven, et al.
(author)
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New Technologies for DNA analysis-A review of the READNA Project.
- 2016
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In: New Biotechnology. - : Elsevier BV. - 1876-4347 .- 1871-6784.
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Research review (peer-reviewed)abstract
- The REvolutionary Approaches and Devices for Nucleic Acid analysis (READNA) project received funding from the European Commission for 4 1/2 years. The objectives of the project revolved around technological developments in nucleic acid analysis. The project partners have discovered, created and developed a huge body of insights into nucleic acid analysis, ranging from improvements and implementation of current technologies to the most promising sequencing technologies that constitute a 3(rd) and 4(th) generation of sequencing methods with nanopores and in situ sequencing, respectively.
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| 12. |
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| 13. |
- Allen, R. C., et al.
(author)
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A statistical study of EMIC waves observed by Cluster : 1. Wave properties
- 2014
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In: 2014 XXXITH URSI General Assembly And Scientific Symposium (URSI GRASS). - 9781467352253
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Conference paper (peer-reviewed)abstract
- Electromagnetic ion cyclotron (EMIC) waves are an important mechanism for particle energization and losses inside the magnetosphere. In order to better understand the effects of these waves on particle dynamics, detailed information about the ellipticity, normal angle, energy propagation angle distributions, and local plasma parameters are required. Previous statistical studies have used in situ observations to investigate the distribution of these parameters in the L-MLT frame within a limited MLAT range. In this study, we present a statistical analysis of EMIC wave properties using ten years (2001-2010) of data from Cluster, totaling 17,987 minutes of wave activity. Due to the polar orbit of Cluster, we are able to investigate EMIC waves at all MLATs and MLTs. This allows us to further investigate the MLAT dependence of various wave properties inside different MLT sectors and further explore the effects of Shabansky orbits on EMIC wave generation and propagation. The current paper focuses on the wave occurrence distribution as well as the distribution of wave properties.
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| 14. |
- Allen, R. C., et al.
(author)
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A statistical study of EMIC waves observed by Cluster : 2. Associated plasma conditions
- 2016
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In: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 121:7, s. 6458-6479
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Journal article (peer-reviewed)abstract
- This is the second in a pair of papers discussing a statistical study of electromagnetic ion cyclotron (EMIC) waves detected during 10years (2001-2010) of Cluster observations. In the first paper, an analysis of EMIC wave properties (i.e., wave power, polarization, normal angle, and wave propagation angle) is presented in both the magnetic latitude (MLAT)-distance as well as magnetic local time (MLT)-L frames. This paper focuses on the distribution of EMIC wave-associated plasma conditions as well as two EMIC wave generation proxies (the electron plasma frequency to gyrofrequency ratio proxy and the linear theory proxy) in these same frames. Based on the distributions of hot H+ anisotropy, electron and hot H+ density measurements, hot H+ parallel plasma beta, and the calculated wave generation proxies, three source regions of EMIC waves appear to exist: (1) the well-known overlap between cold plasmaspheric or plume populations with hot anisotropic ring current populations in the postnoon to dusk MLT region; (2) regions all along the dayside magnetosphere at high L shells related to dayside magnetospheric compression and drift shell splitting; and (3) off-equator regions possibly associated with the Shabansky orbits in the dayside magnetosphere.
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| 15. |
- Allen, R. C., et al.
(author)
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A statistical study of EMIC waves observed by Cluster : 1. Wave properties
- 2015
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In: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 120:7, s. 5574-5592
-
Journal article (peer-reviewed)abstract
- Electromagnetic ion cyclotron (EMIC) waves are an important mechanism for particle energization and losses inside the magnetosphere. In order to better understand the effects of these waves on particle dynamics, detailed information about the occurrence rate, wave power, ellipticity, normal angle, energy propagation angle distributions, and local plasma parameters are required. Previous statistical studies have used in situ observations to investigate the distribution of these parameters in the magnetic local time versus L-shell (MLT-L) frame within a limited magnetic latitude (MLAT) range. In this study, we present a statistical analysis of EMIC wave properties using 10years (2001-2010) of data from Cluster, totaling 25,431min of wave activity. Due to the polar orbit of Cluster, we are able to investigate EMIC waves at all MLATs and MLTs. This allows us to further investigate the MLAT dependence of various wave properties inside different MLT sectors and further explore the effects of Shabansky orbits on EMIC wave generation and propagation. The statistical analysis is presented in two papers. This paper focuses on the wave occurrence distribution as well as the distribution of wave properties. The companion paper focuses on local plasma parameters during wave observations as well as wave generation proxies.
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| 16. |
- Allen, R. C., et al.
(author)
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Multiple bidirectional EMIC waves observed by Cluster at middle magnetic latitudes in the dayside magnetosphere
- 2013
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In: Journal of Geophysical Research: Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 118:10, s. 6266-6278
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Journal article (peer-reviewed)abstract
- It is well accepted that the propagation of electromagnetic ion cyclotron (EMIC) waves are bidirectional near their source regions and unidirectional when away from these regions. The generally believed source region for EMIC waves is around the magnetic equatorial plane. Here we describe a series of EMIC waves in the Pc1 (0.2-5 Hz) frequency band above the local He+ cyclotron frequency observed in situ by all four Cluster spacecraft on 9 April 2005 at midmagnetic latitudes (MLAT = similar to 33 degrees-49 degrees) with L = 10.7-11.5 on the dayside (MLT = 10.3-10.4). A Poynting vector spectrum shows that the wave packets consist of multiple groups of packets propagating bidirectionally, rather than unidirectionally, away from the equator, while the local plasma conditions indicate that the spacecraft are entering into a region sufficient for local wave excitation. One possible interpretation is that, while part of the observed waves are inside their source region, the others are either close enough to the source region, or mixed with the wave packets from multiple source regions at different latitudes.
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| 17. |
- Alm, Love, et al.
(author)
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Magnetotail Hall Physics in the Presence of Cold Ions
- 2018
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In: Geophysical Research Letters. - : Blackwell Publishing Ltd. - 0094-8276 .- 1944-8007. ; 45:20, s. 10,941-10,950
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Journal article (peer-reviewed)abstract
- We present the first in situ observation of cold ionospheric ions modifying the Hall physics of magnetotail reconnection. While in the tail lobe, Magnetospheric Multiscale mission observed cold (tens of eV) E × B drifting ions. As Magnetospheric Multiscale mission crossed the separatrix of a reconnection exhaust, both cold lobe ions and hot (keV) ions were observed. During the closest approach of the neutral sheet, the cold ions accounted for ∼30% of the total ion density. Approximately 65% of the initial cold ions remained cold enough to stay magnetized. The Hall electric field was mainly supported by the j × B term of the generalized Ohm's law, with significant contributions from the ∇·P e and v c ×B terms. The results show that cold ions can play an important role in modifying the Hall physics of magnetic reconnection even well inside the plasma sheet. This indicates that modeling magnetic reconnection may benefit from including multiscale Hall physics.
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| 18. |
- Alm, Love, et al.
(author)
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MMS Observations of Multiscale Hall Physics in the Magnetotail
- 2019
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In: Geophysical Research Letters. - : AMER GEOPHYSICAL UNION. - 0094-8276 .- 1944-8007.
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Journal article (peer-reviewed)abstract
- We present Magnetospheric Multiscale mission (MMS) observations of Hall physics in the magnetotail, which compared to dayside Hall physics is a relatively unexplored topic. The plasma consists of electrons, moderately cold ions (T similar to 1.5 keV) and hot ions (T similar to 20 keV). MMS can differentiate between the cold ion demagnetization region and hot ion demagnetization regions, which suggests that MMS was observing multiscale Hall physics. The observed Hall electric field is compared with a generalized Ohm's law, accounting for multiple ion populations. The cold ion population, despite its relatively high initial temperature, has a significant impact on the Hall electric field. These results show that multiscale Hall physics is relevant over a much larger temperature range than previously observed and is relevant for the whole magnetosphere as well as for other astrophysical plasma.
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| 19. |
- Alvesson, Mats, et al.
(author)
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A Stupidity-Based Theory of Organizations
- 2012
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In: Journal of Management Studies. - : Wiley. - 1467-6486 .- 0022-2380. ; 49:7, s. 1194-1220
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Journal article (peer-reviewed)abstract
- In this paper we question the one-sided thesis that contemporary organizations rely on the mobilization of cognitive capacities. We suggest that severe restrictions on these capacities in the form of what we call functional stupidity are an equally important if under-recognized part of organizational life. Functional stupidity refers to an absence of reflexivity, a refusal to use intellectual capacities in other than myopic ways, and avoidance of justifications. We argue that functional stupidity is prevalent in contexts dominated by economy in persuasion which emphasizes image and symbolic manipulation. This gives rise to forms of stupidity management that repress or marginalize doubt and block communicative action. In turn, this structures individuals' internal conversations in ways that emphasize positive and coherent narratives and marginalize more negative or ambiguous ones. This can have productive outcomes such as providing a degree of certainty for individuals and organizations. But it can have corrosive consequences such as creating a sense of dissonance among individuals and the organization as a whole. The positive consequences can give rise to self-reinforcing stupidity. The negative consequences can spark dialogue, which may undermine functional stupidity.
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| 20. |
- Alvesson, Mats, et al.
(author)
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Critical leadership studies: The case for critical performativity
- 2012
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In: Human Relations. - : SAGE Publications. - 0018-7267 .- 1741-282X. ; 65:3, s. 367-390
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Journal article (peer-reviewed)abstract
- Existing accounts of leadership are underpinned by two dominant approaches: functionalist studies, which have tried to identify correlations between variables associated with leadership; and interpretive studies, which have tried to trace out the meaning-making process associated with leadership. Eschewing these approaches, we turn to an emerging strand of literature that develops a critical approach to leadership. This literature draws our attention to the dialectics of control and resistance and the ideological aspect of leadership. However, it largely posits a negative critique of leadership. We think this is legitimate and important, but extend this agenda. We posit a performative critique of leadership that emphasizes tactics of circumspect care, progressive pragmatism and searching for present potentialities. We use these tactics to sketch out a practice of deliberated leadership that involves collective reflection on when, what kind and if leadership is appropriate.
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| 21. |
- Alvesson, Mats, et al.
(author)
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Critical perspectives on leadership
- 2014
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In: The Oxford Handbook of Leadership and Organizations. - : Oxford University Press. - 9780199755615
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Book chapter (peer-reviewed)abstract
- This chapter reviews the emerging body of literature on critical theories of leadership. It begins by putting critical approaches to leadership in the context of broader debates about leadership. It notes that most existing work builds on either functional or interpretive assumptions. After noting some of the shortcomings with these directions, this chapter offers an alternative set of ideas based on critical theory. These suggest that leadership should be denaturalized and studied reflexively, and that this research should be done with a noninstrumental intent. The chapter then reviews the growing body of work that has built on these ideas. This work addresses issues including ideology, identity, exclusions and inclusions, and interventions. The chapter concludes by outlining a range of areas for future research.
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| 22. |
- Alvesson, Mats, et al.
(author)
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Does leadership create stupidity?
- 2013
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In: Critical Perspectives on Leadership – Emotion, Toxicity and Dysfunction. - 978 0 85793 112 2
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Book chapter (peer-reviewed)
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| 23. |
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| 24. |
- Alvesson, Mats, et al.
(author)
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Neo-Institutional Theory and Organization Studies : A Mid-Life Crisis?
- 2019
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In: Organization Studies. - : SAGE Publications. - 0170-8406 .- 1741-3044. ; 40:2, s. 199-218
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Journal article (peer-reviewed)abstract
- We trace the development of neo-institutional theory in Organization Studies from a marginal topic to the dominant theory. We show how it has evolved from infancy, through adolescence and early adulthood to being a fully mature theory, which we think is now facing a mid-life crisis. Some of the features of this mid-life crisis include over-reach, myopia, tautology, pseudo-progress and re-inventing the wheel. To address these problems, we argue that institutional theorists should limit the range of the concept, sharpen their lens, avoid tautologies and problematize the concept. By doing this, we think institutional theorists could develop a narrower and more focused conception of institutions.
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| 25. |
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